Inhibition of hepatitis C virus replication using adeno-associated virus vector delivery of an exogenous anti-hepatitis C virus microrna cluster

Hepatology ◽  
2010 ◽  
Vol 52 (6) ◽  
pp. 1877-1887 ◽  
Author(s):  
Xiao Yang ◽  
Virginia Haurigot ◽  
Shangzhen Zhou ◽  
Guangxiang Luo ◽  
Linda B Couto
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Virus Vector ◽  
Adeno Associated Virus ◽  
Microrna Cluster ◽  
Vector Delivery

Mechanistic dynamics of Hepatitis C virus replication in single liver cells

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
MM Knodel ◽  
P Targett-Adams ◽  
A Grillo ◽  
S Reiter ◽  
E Herrmann ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Liver Cells

Role of autophagy in hepatitis C virus replication

2019 ◽  
Author(s):  
WI Twu ◽  
K Tabata ◽  
D Paul ◽  
R Bartenschlager
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication

A new system to measure and compare hepatitis C virus replication capacity using full-length, replication competent viruses

2013 ◽  
Vol 194 (1-2) ◽  
pp. 82-88
Author(s):  
Britta Lassmann ◽  
Vaithilingaraja Arumugaswami ◽  
Kara W. Chew ◽  
Martha J. Lewis
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Full Length ◽  
Replication Capacity ◽  
New System

scholarly journals Ribavirin Regulates Hepatitis C Virus Replication Through Enhancing Interferon-Stimulated Genes and Interleukin 8

2012 ◽  
Vol 205 (7) ◽  
pp. 1121-1130 ◽  
Author(s):  
Yoshio Tokumoto ◽  
Yoichi Hiasa ◽  
Kazuhiro Uesugi ◽  
Takao Watanabe ◽  
Toshie Mashiba ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Interleukin 8 ◽  
Interferon Stimulated Genes

scholarly journals Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity

2019 ◽  
Vol 2019 ◽  
pp. 1-11
Author(s):  
Mark G. Swain ◽  
John L. Wallace ◽  
D. Lorne Tyrrell ◽  
José Cabanillas ◽  
Steven K. H. Aung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Gastric Mucosa ◽  
Virus Replication ◽  
Positive Interactions ◽  
Mucosal Integrity ◽  
Immune Mediated ◽  
Anti Inflammatory

The purpose of this study was to determine the efficacy of a Peruvian botanical formulation for treating disorders of hepatic function and gastric mucosal integrity. The formulation A4+ (Sabell Corporation) contains extracts of Curcuma longa rhizome, Cordia lutea flower, and Annona muricata leaf. Individually these plants have been used as traditional remedies for liver disease. We report the efficacy of A4+ and its components using a variety of in vitro and in vivo disease models. The methods used included tests for antioxidant, anti-inflammatory, and antiviral activity as well as mouse models of liver disease, including Concanavalin A-induced immune-mediated hepatitis and a bile duct ligation model for evaluating sickness behaviour associated with liver disease. Rat models were used to evaluate the gastric mucosal protective property of A4+ following indomethacin challenge and to evaluate its anti-inflammatory action in an “air pouch” model. In all tests, A4+ proved to be more effective than placebo. A4+ was antioxidant and anti-inflammatory and diminished Hepatitis C virus replication in vitro. In animal models, A4+ was shown to protect the liver from immune-mediated hepatitis, improve behavioural function in animals with late stage liver disease, and protect the rat gastric mucosa from ulceration following NSAID exposure. We conclude that A4+ ameliorated many aspects of liver injury, inhibited hepatitis C virus replication, and protected the gastric mucosa from NSAIDs. These varied beneficial properties appear to result from positive interactions between the three constituent herbs.

scholarly journals Identification of Human Kinases Involved in Hepatitis C Virus Replication by Small Interference RNA Library Screening

2007 ◽  
Vol 283 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Lubica Supekova ◽  
Frantisek Supek ◽  
Jongkook Lee ◽  
Shawn Chen ◽  
Nathanael Gray ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication ◽  
Library Screening ◽  
Small Interference Rna ◽  
Interference Rna

Let-7b is a novel regulator of hepatitis C virus replication

2012 ◽  
Vol 69 (15) ◽  
pp. 2621-2633 ◽  
Author(s):  
Ju-Chien Cheng ◽  
Yung-Ju Yeh ◽  
Ching-Ping Tseng ◽  
Sheng-Da Hsu ◽  
Yu-Ling Chang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Replication
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