Overlapping high-resolution copy number alterations in cancer genomes identified putative cancer genes in hepatocellular carcinoma

Hepatology ◽  
2010 ◽  
Vol 52 (5) ◽  
pp. 1690-1701 ◽  
Author(s):  
Chian-Feng Chen ◽  
En-Chi Hsu ◽  
Kuen-Tyng Lin ◽  
Pang-Hsien Tu ◽  
Hung-Wei Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
High Resolution ◽  
Copy Number ◽  
Cancer Genes ◽  
Copy Number Alterations ◽  
Cancer Genomes

Sex-dependent differences in DNA copy number alterations in hepatocellular carcinoma

2012 ◽  
Vol 32 (1) ◽  
pp. 5-9 ◽  
Author(s):  
Bing-ji WEN ◽  
Wen-ming CONG ◽  
Ai-zhong WANG ◽  
Song-qin HE ◽  
Hong-mei JIANG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Copy Number ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Dna Copy Number Alterations

Genome-Wide High-Resolution Screening in Dupuytren's Disease Reveals Common Regions of DNA Copy Number Alterations

2010 ◽  
Vol 35 (7) ◽  
pp. 1172-1183.e7 ◽  
Author(s):  
Barbara B. Shih ◽  
May Tassabehji ◽  
James S. Watson ◽  
Angus D. McGrouther ◽  
Ardeshir Bayat
Keyword(s):  
High Resolution ◽  
Copy Number ◽  
Dupuytren’S Disease ◽  
Copy Number Alterations ◽  
Dna Copy Number ◽  
Dupuytren's Disease ◽  
Genome Wide ◽  
Dna Copy Number Alterations

scholarly journals Genome-wide copy number analyses identified novel cancer genes in hepatocellular carcinoma

Hepatology ◽  
2011 ◽  
Vol 54 (4) ◽  
pp. 1227-1236 ◽  
Author(s):  
Deshui Jia ◽  
Lin Wei ◽  
Weijie Guo ◽  
Ruopeng Zha ◽  
Meiyan Bao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Copy Number ◽  
Cancer Genes ◽  
Genome Wide

scholarly journals Convergent Evolution of Copy Number Alterations in Multi-Centric Hepatocellular Carcinoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Carolin Lackner ◽  
Luca Quagliata ◽  
William Cross ◽  
Sebastian Ribi ◽  
Karl Heinimann ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Copy Number ◽  
Convergent Evolution ◽  
Copy Number Alterations

Abstract 1304: Whole-exome analysis of 1,135 melanomas reveals new significantly mutated cancer genes and copy number alterations

2018 ◽  
Author(s):  
Jake R. Conway ◽  
David Liu ◽  
Stephanie Wankowicz ◽  
Amaro Taylor-Weiner ◽  
Felix Dietlein ◽  
...  
Keyword(s):  
Copy Number ◽  
Cancer Genes ◽  
Copy Number Alterations ◽  
Whole Exome ◽  
Exome Analysis

High-resolution genomic and expression analyses of copy number alterations in breast tumors

2008 ◽  
Vol 47 (6) ◽  
pp. 530-542 ◽  
Author(s):  
Peter M. Haverty ◽  
Jane Fridlyand ◽  
Li Li ◽  
Gad Getz ◽  
Rameen Beroukhim ◽  
...  
Keyword(s):  
High Resolution ◽  
Copy Number ◽  
Breast Tumors ◽  
Copy Number Alterations

scholarly journals Clinical implication of recurrent copy number alterations in hepatocellular carcinoma and putative oncogenes in recurrent gains on 1q

2008 ◽  
Vol 123 (12) ◽  
pp. 2808-2815 ◽  
Author(s):  
Tae-Min Kim ◽  
Seon-Hee Yim ◽  
Seung-Hun Shin ◽  
Hai-Dong Xu ◽  
Yu-Chae Jung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Clinical Implication ◽  
Copy Number ◽  
Copy Number Alterations

High Resolution Screening of Copy-Number Alterations in Chronic Lymphocytic Leukemia Using Affymetrix 250K SNP-Arrays Reveals a Higher Complexity of Genomic Alterations in Patients with Unmutated IGHV Genes

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3133-3133
Author(s):  
Rebeqa Gunnarsson ◽  
Anders Isaksson ◽  
Hanna Göransson ◽  
Larry Mansouri ◽  
Mattias Jansson ◽  
...  
Keyword(s):  
High Resolution ◽  
Copy Number ◽  
Average Length ◽  
Lymphocytic Leukemia ◽  
Copy Number Alterations ◽  
Snp Arrays ◽  
Genetic Complexity ◽  
Trisomy 12 ◽  
Allelic Deletion ◽  
Gains And Losses

Abstract Chronic lymphocytic leukemia (CLL) is a biologically heterogeneous disease where no common genetic aberration so far has been described. Although recurrent genomic aberrations of prognostic significance are well established (e.g. deletions of 11q, 13q, 17p and trisomy 12), less is known about the overall genetic complexity. Recent development of high-resolution single nucleotide polymorphism (SNP)-arrays will allow screening of genetic complexity, which includes detection of smaller copy-number alterations (CNAs) in addition to the known, recurrent aberrations. We here applied the Affymetrix GeneChip® Mapping 250K Nsp arrays and screened peripheral blood samples from 203 newly diagnosed CLL patients (≥70% tumor cells) from a population-based Scandinavian cohort. The male:female ratio was 2:1, the majority of patients was in stage A (70%) and the median age at diagnosis 61 years. Sixty percentage of cases displayed mutated IGHV genes whereas 35% showed unmutated IGHV genes. The Nexus copy-number software (Biodiscovery, Inc.) was applied and CNAs were identified in all CLL samples investigated, where deletions were more commonly detected than gains (in average, 3.5 vs. 2.2 per sample, respectively). The average length of deletions was 3.5 Mb while gains had an average length of 9.5 Mb (3.6 Mb when excluding trisomy 12). More than 50% of deletions and gains had a size ranging between 0.1–1 Mb, whereas 22% of CNAs were less than 0.1 Mb and 25% larger than 1 Mb. When investigating known, recurrent alterations, 105 samples (52%) carried del(13)(q14); 82 samples displayed a mono-allelic deletion, 15 samples a bi-allelic deletion and 8 samples carried 2 mono-allelic deletions of different sizes. The minimal overlapping region was 0.44 Mb and most of the 13q14 deletions covered the genomic region of miR-15, miR-16 and/or DLEU7. Twenty-one samples (10%) showed trisomy 12 and del(11q) was detected in 27 samples (13%), all covering the ATM gene. del(17p) was detected in 7 patients (3.4%) with one patient also carrying several gains and losses of 17q. Moreover, large alterations involving chromosome arms or entire chromosomes were recurrently observed among the samples, for instance, 3 large 8p losses and 4 large 8q gains. Interestingly, 5 samples, which all carried del(11q), displayed a gain covering whole or large parts of the p-arm of chromosome 2, a region which covers MYCN, REL and BCL11A. Furthermore, comparison of samples with different IGHV mutation status (M vs. UM) illustrated a significantly higher frequency of del(11q) (32% of UM vs. 4% of M), trisomy 12 (22% of UM vs. 5% of M) and gain of 2p (12% vs. 0% in M) in samples with unmutated IGHV genes. As expected, patients with mutated IGHV genes showed a higher frequency of del(13q) (61% of M vs. 31% of UM). In addition, large aberrations (>1Mb) were more common in UM samples which in average displayed 0.57 gains and 1.22 deletions compared to 0.26 gains and 0.67 deletions in M samples. In conclusion, with whole-genome screening using high resolution SNP-arrays, higher complexity was revealed in CLL, including a higher number of gains and losses and a higher frequency of larger aberrations in UM compared to M samples. A novel, recurrent combination of del(11q) and gain of 2p was demonstrated which deserves further investigation.

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