Is cigarette smoking an independent risk factor or a cofactor for nonalcoholic fatty liver disease?

Hepatology ◽  
2010 ◽  
Vol 52 (2) ◽  
pp. 803-804 ◽  
Author(s):  
Cheng-Fu Xu ◽  
Chao-Hui Yu ◽  
Lei Xu ◽  
Min Miao ◽  
You-Ming Li
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Cigarette Smoking ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease is an independent risk factor for atherosclerosis in young adult men

2015 ◽  
Vol 240 (2) ◽  
pp. 380-386 ◽  
Author(s):  
Kadir Ozturk ◽  
Ahmet Uygun ◽  
Ahmet Kerem Guler ◽  
Hakan Demirci ◽  
Cafer Ozdemir ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Young Adult ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Nonalcoholic Fatty Liver ◽  
Adult Men

Increased Prevalence of Colorectal Adenomas in Patients with Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

2019 ◽  
Vol 38 (3) ◽  
pp. 222-230 ◽  
Author(s):  
John William Blackett ◽  
Elizabeth C. Verna ◽  
Benjamin Lebwohl
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Colorectal Adenomas ◽  
Advanced Fibrosis ◽  
Nonalcoholic Fatty Liver ◽  
Adenoma Detection

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Previous studies have suggested an association between colorectal adenomas and NAFLD but are limited by a lack of biopsy-proven NAFLD or comparison with matched controls. Objectives: We aimed to determine whether histologically demonstrated NAFLD is an independent risk factor for colorectal adenomas. Methods: Patients who underwent liver biopsy showing steatosis who had also undergone screening or surveillance colonoscopy in 2007–2017 were retrospectively studied by manual chart review, excluding patients with liver disease other than NAFLD. Adenoma detection rates and characteristics such as location, histologic type, and size were compared in the resulting 123 NAFLD patients against controls without liver disease matched by age, gender, and endoscopist. Results: Adenoma prevalence was significantly higher in the NAFLD group at 40.7 versus 28.1% in controls (OR 1.87, 95% CI 1.15–3.03, p = 0.01) and remained significant on multivariable analysis controlling for rates of hyperlipidemia, diabetes, and obesity (OR 1.74, 95% CI 1.05–2.88, p = 0.032). Comparing NAFLD patients with advanced fibrosis to those with simple steatosis, there was a trend toward higher adenoma prevalence in advanced fibrosis (50.0 vs. 36.8%; OR 1.84, 95% CI 0.50–6.70, p = 0.36). Conclusions: Patients with histologically demonstrated NAFLD had a significantly higher adenoma prevalence on colonoscopy compared to matched controls, which remained significant after adjusting for rates of diabetes, obesity, and hyperlipidemia. NAFLD should be investigated further as an independent risk factor for colorectal neoplasia.

Nonalcoholic Fatty Liver Disease Is an Independent Risk Factor for Nephrolithiasis in Women: Findings from NHANES III

2020 ◽  
Vol 34 (12) ◽  
pp. 1258-1262
Author(s):  
Rourke D. Decker ◽  
Eric M. Ghiraldi ◽  
Alexandra H. Weiss ◽  
John P. Gaughan ◽  
Justin I. Friedlander
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Nhanes Iii ◽  
Nonalcoholic Fatty Liver

scholarly journals Study on the correlation between urinary retinol binding protein and nonalcoholic fatty liver disease

2020 ◽  
Author(s):  
Chuang Li ◽  
Weiwei Kong ◽  
Lixia Kang ◽  
Weiqun Zhang ◽  
Weidong Wang ◽  
...  
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Cross Sectional ◽  
Nonalcoholic Fatty Liver

Background: Our objective was to explore the correlation between urinary retinol binding protein (URBP) and nonalcoholic fatty liver disease (NAFLD).Methods: 445 NAFLD patients and 911 healthy controls were enrolled into this cross-sectional study. URBP level and other parameters were measured.Results: The URBP level was higher in NAFLD compared with non-NAFLD patients. URBP was an independent risk factor for NAFLD after univariate and multivariate regression analysis, with OR values of 3.995 (2.928–5.451, P < 0.001) and 4.173 (2.894–6.018, P < 0.001), respectively. The prevalence of URBP (groups 1, 2, 3, 4) was 25.4%, 22.4%, 33.1%, and 50.4%, respectively (P < 0.001), and the prevalence of NAFLD in high URBP group was significantly higher than that in low URBP group.Conclusions: Our results revealed that URBP was an independent risk factor for NAFLD.

scholarly journals A Low Creatinine to Body Weight Ratio Predicts the Incident Nonalcoholic Fatty Liver Disease in Nonelderly Chinese without Obesity and Dyslipidemia: A Retrospective Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jianxiong Lin ◽  
Jiehua Zheng ◽  
Xiaoqing Lin ◽  
Yexi Chen ◽  
Zhiyang Li
Keyword(s):  
Body Weight ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Cumulative Incidence ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
The Elderly ◽  
Nonalcoholic Fatty Liver

Aim. A lower ratio of creatinine to body weight (Cr/BW) is considered the independent risk factor for incident nonalcoholic fatty liver disease (NAFLD). However, the relationship between the Cr/BW ratio and NAFLD among individuals without obesity and dyslipidemia and how this relationship is impacted by age are still ambiguous. Therefore, we explored the effect of the Cr/BW ratio on the incident NAFLD among Chinese without obesity and dyslipidemia of different age groups. Methods. A total of 9756 participants without NAFLD at baseline were included and grouped by the median value (1.32) of the Cr/BW ratio. Then, a further analysis was stratified by age (60 years old). The primary outcome was new-onset NAFLD. Results. After a median follow-up of 2.76 years, 844 (8.7%) participants developed NAFLD. The elderly had a higher person-years incidence rate and cumulative incidence rate than the nonelderly. A high Cr/BW ratio showed a lower cumulative incidence compared to a low Cr/BW ratio for the whole population (P=0.039) and the nonelderly group (P=0.008). After being adjusted for multivariate variables, the lower Cr/BW ratio was the independent risk factor for incident NAFLD in the nonelderly (HR 0.718, 95% CI 0.548-0.942), instead of the elderly. Conclusions. The Cr/BW ratio has a negative relationship with incident NAFLD among nonobese Chinese without dyslipidemia before the age of 60.

Sarcopenia Is a New Risk Factor of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease

2020 ◽  
Vol 38 (6) ◽  
pp. 507-514
Author(s):  
Min Kyu Kang ◽  
Kyeong Ok Kim ◽  
Min Cheol Kim ◽  
Jung Gil Park ◽  
Byung Ik Jang
Keyword(s):  
Inflammatory Bowel Disease ◽  
Risk Factor ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Bowel Disease ◽  
Fatty Liver Disease ◽  
Independent Risk Factor ◽  
Nonalcoholic Fatty Liver ◽  
Inflammatory Bowel

<b><i>Background and Aim:</i></b> Recently, sarcopenia has been proposed as an additional risk factor of nonalcoholic fatty liver disease (NAFLD), and there have been no studies in patients with inflammatory bowel disease (IBD). We aimed to analyze the clinical associations between sarcopenia and NAFLD in IBD patients. <b><i>Methods:</i></b> From January 2004 to December 2017, a total of 488 IBD patients, with CT results, were classified according to the presence of NAFLD. Sarcopenia was assessed based on the muscle volume calculated by the total psoas muscle area in the third lumbar region divided by the square of the patient’s height (m<sup>2</sup>). <b><i>Results:</i></b> Among the 443 included patients, NAFLD was diagnosed in 49 patients (11.1%). Sarcopenia was noted in 34.9%; it was more common in the NAFLD group (51.0 vs. 33.0%; <i>p</i> = 0.019). In multivariate analysis, metabolic syndrome (odds ratio [OR], 8.63), hyperuricemia (OR, 4.66), small bowel resection (OR, 3.45), and sarcopenia (OR, 2.99) were significant risk factors of NAFLD in IBD patients. In addition, sarcopenia was an independent risk factor after adjustment for age, sex, and other metabolic factors (OR, 2.26). <b><i>Conclusions:</i></b> The prevalence of nonalcoholic fatty liver in IBD patients was 11.1%, and sarcopenia was an independent risk factor.

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