scholarly journals Long-term mortality in nonalcoholic fatty liver disease: Is liver histology of any prognostic significance?

Hepatology ◽  
2010 ◽  
Vol 51 (2) ◽  
pp. 373-375 ◽  
Author(s):  
Paul Angulo
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Prognostic Significance ◽  
Liver Histology ◽  
Nonalcoholic Fatty Liver ◽  
Long Term Mortality

scholarly journals Role of Docosahexaenoic Acid Treatment in Improving Liver Histology in Pediatric Nonalcoholic Fatty Liver Disease

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88005 ◽  
Author(s):  
Valerio Nobili ◽  
Guido Carpino ◽  
Anna Alisi ◽  
Rita De Vito ◽  
Antonio Franchitto ◽  
...  
Keyword(s):  
Liver Disease ◽  
Docosahexaenoic Acid ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Acid Treatment ◽  
Liver Histology ◽  
Nonalcoholic Fatty Liver

scholarly journals Association between cytokines and liver histology in children with nonalcoholic fatty liver disease

2017 ◽  
Vol 1 (7) ◽  
pp. 609-622 ◽  
Author(s):  
Emily R. Perito ◽  
Veeral Ajmera ◽  
Nathan M. Bass ◽  
Philip Rosenthal ◽  
Joel E. Lavine ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Histology ◽  
Nonalcoholic Fatty Liver

The Impact of Aspirin Use on Liver Histology in Patients With Nonalcoholic Fatty Liver Disease (NAFLD)

2015 ◽  
Vol 110 ◽  
pp. S891-S892
Author(s):  
Bashar Mohamad ◽  
Razan Alhaddad ◽  
John Guirguis ◽  
Rocio Lopez ◽  
Ibrahim A. Hanouneh ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Histology ◽  
Nonalcoholic Fatty Liver ◽  
The Impact

scholarly journals Metabolomics Characterizes the Effects and Mechanisms of Quercetin in Nonalcoholic Fatty Liver Disease Development

2019 ◽  
Vol 20 (5) ◽  
pp. 1220 ◽  
Author(s):  
Yan Xu ◽  
Jichun Han ◽  
Jinjin Dong ◽  
Xiangcheng Fan ◽  
Yuanyuan Cai ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Hepatoprotective Activity ◽  
High Fat ◽  
Nonalcoholic Fatty Liver ◽  
Adrenic Acid ◽  
Experimental Approaches

As metabolomics is widely used in the study of disease mechanisms, an increasing number of studies have found that metabolites play an important role in the occurrence of diseases. The aim of this study is to investigate the effects and mechanisms of quercetin in high-fat-sucrose diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) development using nontargeted metabolomics. A rat model of NAFLD was established by feeding with an HFD for 30 and 50 days. The results indicated quercetin exhibited hepatoprotective activity in 30-day HFD-induced NAFLD rats by regulating fatty acid related metabolites (adrenic acid, etc.), inflammation-related metabolites (arachidonic acid, etc.), oxidative stress-related metabolites (2-hydroxybutyric acid) and other differential metabolites (citric acid, etc.). However, quercetin did not improve NAFLD in the 50-day HFD; perhaps quercetin was unable to reverse the inflammation induced by a long-term high-fat diet. These data indicate that dietary quercetin may be beneficial to NAFLD in early stages. Furthermore, combining metabolomics and experimental approaches opens avenues to study the effects and mechanisms of drugs for complex diseases.

Sign in / Sign up

Export Citation Format

Share Document