scholarly journals Diagnostic criteria for autoimmune hepatitis: What is the gold standard?

Hepatology ◽  
2009 ◽  
Vol 51 (1) ◽  
pp. 350-351 ◽  
Author(s):  
Rajan Kochar ◽  
Michael Fallon
Keyword(s):  
Autoimmune Hepatitis ◽  
Diagnostic Criteria ◽  
Gold Standard

Diagnostic criteria for autoimmune hepatitis

2011 ◽  
Vol 25 (6) ◽  
pp. 665-671 ◽  
Author(s):  
Ansgar W. Lohse ◽  
Christiane Wiegard
Keyword(s):  
Autoimmune Hepatitis ◽  
Diagnostic Criteria

scholarly journals The impact of sonication cultures when the diagnosis of prosthetic joint infection is inconclusive

PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0252322
Author(s):  
Taiana Cunha Ribeiro ◽  
Emerson Kiyoshi Honda ◽  
Daniel Daniachi ◽  
Ricardo de Paula Leite Cury ◽  
Cely Barreto da Silva ◽  
...  
Keyword(s):  
Tissue Culture ◽  
Diagnostic Criteria ◽  
Gold Standard ◽  
Joint Infection ◽  
Clinical Criterion ◽  
Tissue Cultures ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
The Impact ◽  
Sonication Culture

Background In the absence of a gold standard criterion for diagnosing prosthetic joint infections (PJI), sonication of the removed implant may provide superior microbiological identification to synovial fluid and peri-implant tissue cultures. The aim of this retrospective study was to assess the role of sonication culture compared to tissue cultures for diagnosing PJI, using different consensus and international guidelines for PJI definition. Methods Data of 146 patients undergoing removal of hip or knee arthroplasties between 2010 and 2018 were retrospectively reviewed. The International Consensus Meeting (ICM-2018), Musculoskeletal Infection Society (MSIS), Infectious Diseases Society of America (IDSA), the European Bone and Joint Infection Society (EBJIS), and a modified clinical criterion, were used to compare the performance of microbiological tests. McNemar´s test and proportion comparison were employed to calculate p-value. Results Overall, 56% (82/146) were diagnosed with PJI using the clinical criteria. Out of these cases, 57% (47/82) tested positive on tissue culture and 93% (76/82) on sonication culture. Applying this clinical criterion, the sensitivity of sonication fluid and tissue cultures was 92.7% (95% CI: 87.1%- 98.3%) and 57.3% (95% CI: 46.6%-68.0%) (p<0.001), respectively. When both methods were combined for diagnosis (sonication and tissue cultures) sensitivity reached 96.3% (95% CI: 91.5%-100%). Sonication culture and the combination of sonication with tissue cultures, showed higher sensitivity rates than tissue cultures alone for all diagnostic criteria (ICM-18, MSIS, IDSA and EBJIS) applied. Conversely, tissue culture provided greater specificity than sonication culture for all the criteria assessed, except for the EBJIS criteria, in which sonication and tissue cultures specificity was 100% and 95.3% (95% CI: 87.8–100%), respectively (p = 0.024). Conclusions In a context where diagnostic criteria available have shortcomings and tissue cultures remain the gold standard, sonication cultures can aid PJI diagnosis, especially when diagnostic criteria are inconclusive due to some important missing data (joint puncture, histology).

Toward diagnostic criteria for autoimmune hepatitis

Hepatology ◽  
1993 ◽  
Vol 18 (4) ◽  
pp. 1006-1008 ◽  
Author(s):  
Ian R. Mackay
Keyword(s):  
Autoimmune Hepatitis ◽  
Diagnostic Criteria

Diagnostic Criteria for Autoimmune Hepatitis: Scores and More

2015 ◽  
Vol 33 (Suppl. 2) ◽  
pp. 47-52 ◽  
Author(s):  
Ansgar W. Lohse
Keyword(s):  
Liver Biopsy ◽  
Autoimmune Hepatitis ◽  
Diagnostic Criteria ◽  
Clinical Use ◽  
Serological Markers ◽  
Diagnostic Score ◽  
Different Populations ◽  
International Autoimmune Hepatitis Group ◽  
Patient’S History ◽  
Diagnostic Scores

The diagnosis of autoimmune hepatitis is a clinical diagnosis that combines the patient's history, clinical examination, laboratory and serological markers and the results of a liver biopsy. As the clinical spectrum of autoimmune hepatitis is very wide, making the diagnosis can sometimes be difficult, especially in non-expert hands. Diagnostic scores can help in making the diagnosis, and the simplified diagnostic score of the International Autoimmune Hepatitis Group has a sensitivity and specificity of around 90% in the different populations that have been studied. Therefore, it can be very helpful in everyday use, but nonetheless for some patients the score is not good enough. Limitations are patients with very acute presentations as well as atypical cases. In such cases, a trial of monotherapy with steroids and quick tapering of the steroids is recommended. If the disease responds well to treatment, but recurs after tapering the steroids, the diagnosis of autoimmune hepatitis is confirmed. In addition to its clinical use, diagnostic scores can also be helpful in defining the unified criteria in order to make scientific studies comparable.

scholarly journals Validation of simplified diagnostic criteria for autoimmune hepatitis in Italian patients

Hepatology ◽  
2009 ◽  
Vol 49 (5) ◽  
pp. 1782-1783 ◽  
Author(s):  
Paolo Muratori ◽  
Alessandro Granito ◽  
Georgios Pappas ◽  
Luigi Muratori
Keyword(s):  
Autoimmune Hepatitis ◽  
Diagnostic Criteria

Appropriate diagnostic criteria for fulminant autoimmune hepatitis

2015 ◽  
Vol 27 (10) ◽  
pp. 1230-1231 ◽  
Author(s):  
Keiichi Fujiwara ◽  
Shin Yasui ◽  
Osamu Yokosuka
Keyword(s):  
Autoimmune Hepatitis ◽  
Diagnostic Criteria

Rigorous New Approach to Constructing a Gold Standard for Validating New Diagnostic Criteria, as Exemplified by the Eosinophilia-Myalgia Syndrome

2001 ◽  
Vol 161 (19) ◽  
pp. 2301 ◽  
Author(s):  
Phillip A. Hertzman ◽  
Daniel J. Clauw ◽  
Joseph Duffy ◽  
Thomas A. Medsger, Jr ◽  
Alvan R. Feinstein
Keyword(s):  
Diagnostic Criteria ◽  
Gold Standard ◽  
New Approach ◽  
Eosinophilia Myalgia Syndrome

Development of Diagnostic Criteria for Common Warts (Verrucae Vulgaris)

1997 ◽  
Vol 2 (2) ◽  
pp. 78-82 ◽  
Author(s):  
Richard Young ◽  
Monique Kilkenny ◽  
Damien Jolley ◽  
Robin Marks
Keyword(s):  
Logistic Regression ◽  
Diagnostic Criteria ◽  
Gold Standard ◽  
Flesh Colour ◽  
Medical Practitioners ◽  
Common Warts ◽  
Common Skin ◽  
Verrucae Vulgaris ◽  
Skin Conditions ◽  
Criteria For Diagnosis

Background: Warts are common skin conditions. In most instances, their diagnosis by medical practitioners is a subjective or intuitive decision. Objective: To develop and assess a minimum set of diagnostic criteria for diagnosis of common warts. Methods: Patients with warts and other lesions were recruited. The lesions were diagnosed by the key dermatologist, whose diagnosis was used as the gold standard. They were then examined by two independent medical practitioners, who used a checklist of diagnostic criteria to determine whether the lesions had any or all of the characteristics. A minimum set of diagnostic criteria for common warts was then derived using logistic regression. Results: The diagnostic criteria were: site of wart (elbow, finger, or knee), flesh colour, hyperkeratosis, and discrete margin. Conclusion: Further studies are needed to compare these diagnostic criteria with the medical practitioners' intuitive diagnosis.

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