Loss of hepatocyte nuclear factor 1α function in human hepatocellular adenomas leads to aberrant activation of signaling pathways involved in tumorigenesis

Hepatology ◽  
2009 ◽  
Vol 51 (2) ◽  
pp. 557-566 ◽  
Author(s):  
Laura Pelletier ◽  
Sandra Rebouissou ◽  
Alain Paris ◽  
Estelle Rathahao-Paris ◽  
Elisabeth Perdu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 1Α ◽  
Hepatocellular Adenomas

scholarly journals Hepatocyte Nuclear Factor 1α-Mutated Hepatocellular Adenomas: An Atypical Presentation

2017 ◽  
Vol 11 (3) ◽  
pp. 645-650
Author(s):  
Camila Maria Neves de Sousa ◽  
Patricia Maria Miranda Gadelha ◽  
Rafaella de Sousa Cartaxo ◽  
George Washington Holanda Pedrosa ◽  
Rodrigo Schuler Honorio ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Phenotypic Characteristics ◽  
Contraceptive User ◽  
Choice Of Treatment ◽  
Hepatocyte Nuclear Factor 1Α ◽  
Primary Risk Factor ◽  
Hepatocellular Adenomas

Hepatocellular adenomas (HCAs) are rare benign monoclonal hepatic tumors that commonly occur in females (3–4 per 100,000 women) due to the use of oral contraceptives, its primary risk factor. Recently, HCAs have been classified into 4 distinct subtypes according to genotypic and phenotypic characteristics and clinical features: inflammatory HCA (40–50%), which are hypervascular with marked peliosis and a tendency to bleed; hepatocyte nuclear factor 1α (HNF1A)-mutated HCA (H-HCA, 30–40%) that are diffusely steatotic and rarely undergo malignant transformation; β-catenin activated HCA (10–15%), which frequently undergo malignant transformation and may seem hepatocellular carcinoma on imaging; and unclassified HCA (10–25%). In this study, we report the case of a 23-year-old female oral contraceptive user with H-HCA. Usually, H-HCA is considered to be nonsevere in most cases and often requires outpatient follow-up. However, in this case, the injury had substantially increased in volume and evolved with a major bleeding frame, which was an unusual finding for this subtype of adenoma. The therapeutic used for this patient was a laparoscopic left hepatic segmentectomy. Thus, the choice of treatment to be performed in a patient with H-HCA can depend on the tumor size (>5 cm), the outcome of previous bleeding, and the risk of bleeding recurrence.

scholarly journals Proteomic screen defines the hepatocyte nuclear factor 1α-binding partners and identifies HMGB1 as a new cofactor of HNF1α

2007 ◽  
Vol 36 (4) ◽  
pp. 1209-1219 ◽  
Author(s):  
Miao Yu ◽  
Jian Wang ◽  
Wei Li ◽  
Yan Zhi Yuan ◽  
Chang Yan Li ◽  
...  
Keyword(s):  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Proteomic Screen ◽  
Binding Partners ◽  
Hepatocyte Nuclear Factor 1Α

scholarly journals Hepatocyte Nuclear Factor-1α, GATA-4, and Caudal Related Homeodomain Protein Cdx2 Interact Functionally to Modulate Intestinal Gene Transcription

2002 ◽  
Vol 277 (35) ◽  
pp. 31909-31917 ◽  
Author(s):  
François Boudreau ◽  
Edmond H. H. M. Rings ◽  
Herbert M. van Wering ◽  
Richard K. Kim ◽  
Gary P. Swain ◽  
...  
Keyword(s):  
Gene Transcription ◽  
Homeodomain Protein ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 1Α

scholarly journals GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in Hepatocyte Nuclear Factor 1α Mutation Carriers

Diabetes ◽  
2020 ◽  
Vol 69 (9) ◽  
pp. 1989-2002 ◽  
Author(s):  
Alexander S. Christensen ◽  
Sofie Hædersdal ◽  
Heidi Storgaard ◽  
Kathrine Rose ◽  
Nina L. Hansen ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Mutation Carriers ◽  
Hepatocyte Nuclear Factor 1Α

scholarly journals Characterization of Human Pterin-4a-carbinolamine Dehydratase/Dimerization Cofactor of Hepatocyte Nuclear Factor-1α, and of the Cys81-mutant Involved in Hyperphenylalanincemia

Pteridines ◽  
1995 ◽  
Vol 6 (3) ◽  
pp. 123-125 ◽  
Author(s):  
Sandra Köster ◽  
Beat Thöny ◽  
Peter Macheroux ◽  
Hans-Christoph Curtius ◽  
Claus W. Heizmann ◽  
...  
Keyword(s):  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 1Α

scholarly journals Mutation of TCF1 encoding hepatocyte nuclear factor 1α in gynecological cancer

Oncogene ◽  
2004 ◽  
Vol 23 (45) ◽  
pp. 7588-7592 ◽  
Author(s):  
Sandra Rebouissou ◽  
Christophe Rosty ◽  
Fabrice Lecuru ◽  
Sophie Boisselier ◽  
Hung Bui ◽  
...  
Keyword(s):  
Gynecological Cancer ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 1Α

Structure/Function Studies of Hepatocyte Nuclear Factor-1α, a Diabetes-Associated Transcription Factor

1999 ◽  
Vol 266 (1) ◽  
pp. 196-202 ◽  
Author(s):  
Qin Yang ◽  
Kazuya Yamagata ◽  
Koji Yamamoto ◽  
Jun-ichiro Miyagawa ◽  
Jun Takeda ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Structure Function ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
Hepatocyte Nuclear Factor 1Α
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