Lack of interleukin-6/glycoprotein 130/signal transducers and activators of transcription-3 signaling in hepatocytes predisposes to liver steatosis and injury in mice

Hepatology ◽  
2009 ◽  
Vol 51 (2) ◽  
pp. 463-473 ◽  
Author(s):  
Daniela C. Kroy ◽  
Naiara Beraza ◽  
Darjus F. Tschaharganeh ◽  
Leif E. Sander ◽  
Stephanie Erschfeld ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Liver Steatosis ◽  
Signal Transducers ◽  
Transcription 3 ◽  
Signal Transducers And Activators

scholarly journals Preconditioning Mediated by Sublethal Oxygen—Glucose Deprivation-Induced Cyclooxygenase-2 Expression via the Signal Transducers and Activators of Transcription 3 Phosphorylation

2008 ◽  
Vol 28 (7) ◽  
pp. 1329-1340 ◽  
Author(s):  
Eun J Kim ◽  
Ami P Raval ◽  
Miguel A Perez-Pinzon
Keyword(s):  
Glucose Deprivation ◽  
Cyclooxygenase 2 ◽  
Serine Phosphorylation ◽  
Signaling Cascade ◽  
Oxygen Glucose Deprivation ◽  
Signal Transducers ◽  
Extracellular Signal ◽  
Cox 2 ◽  
Transcription 3 ◽  
Signal Transducers And Activators

The signal transducers and activators of transcription (STATs) were found to be essential for cardioprotection. However, their role in preconditioning (PC) neuroprotection remains undefined. Previously, our studies showed that PC mediated a signaling cascade that involves activation of epsilon protein kinase C (εPKC), extracellular signal-regulated kinase (ERK1/2), and cyclooxygenase-2 (COX-2) pathways. However, the intermediate pathway by which ERK1/2 activates COX-2 was not defined. In this study, we investigated whether the PC-induced signaling pathway requires phosphorylation of STAT isoforms for COX-2 expression. To mimic PC or lethal ischemia, mixed cortical neuron/astrocyte cell cultures were subjected to 1 and/or 4 h of oxygen—glucose deprivation (OGD), respectively. The results indicated serine phosphorylation of STAT3 after PC or εPKC activation. Inhibition of either εPKC or ERK1/2 activation abolished PC-induced serine phosphorylation of STAT3. Additionally, inhibition of STAT3 prevented PC-induced COX-2 expression and neuroprotection against OGD. Therefore, our findings suggest that PC signaling cascade involves STAT3 activation after εPKC and ERK1/2 activation. Finally, we show that STAT3 activation mediates COX-2 expression and ischemic tolerance.

scholarly journals Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension

Circulation ◽  
2011 ◽  
Vol 123 (11) ◽  
pp. 1205-1215 ◽  
Author(s):  
Roxane Paulin ◽  
Audrey Courboulin ◽  
Jolyane Meloche ◽  
Vincent Mainguy ◽  
Eric Dumas de la Roque ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Critical Role ◽  
Signal Transducers ◽  
Pulmonary Arterial ◽  
Transcription 3 ◽  
Signal Transducers And Activators

Role of oxidative stress in the increased activation of signal transducers and activators of transcription-3 in the fatty livers of obese Zucker rats

Surgery ◽  
2004 ◽  
Vol 136 (3) ◽  
pp. 677-685 ◽  
Author(s):  
George S. Dikdan ◽  
Salim C. Saba ◽  
Andrew N. dela Torre ◽  
Jonathan Roth ◽  
Shulun Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Zucker Rats ◽  
Signal Transducers ◽  
Fatty Livers ◽  
Obese Zucker Rats ◽  
Transcription 3 ◽  
Signal Transducers And Activators
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