Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis

Hepatology ◽  
2009 ◽  
Vol 50 (6) ◽  
pp. 1936-1945 ◽  
Author(s):  
Eiji Kakazu ◽  
Yoshiyuki Ueno ◽  
Yasuteru Kondo ◽  
Koji Fukushima ◽  
Masaaki Shiina ◽  
...  
Keyword(s):  
Amino Acids ◽  
Dendritic Cells ◽  
Ex Vivo ◽  
Branched Chain Amino Acids ◽  
Myeloid Dendritic Cells ◽  
Advanced Cirrhosis ◽  
Branched Chain ◽  
And Function

Biosynthesis of Branched-Chain Amino Acids in Plants: Structure and Function of Acetohydroxy Acid Isomeroreductase

1995 ◽  
pp. 4227-4232
Author(s):  
Valérie Biou ◽  
Eva Pebay-Peyroula ◽  
Claudine Cohen-Addad ◽  
Françoise Vives ◽  
Marie-Christine Butikofer ◽  
...  
Keyword(s):  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Structure And Function ◽  
Branched Chain ◽  
And Function

Branched-chain amino acids and respiratory pattern and function in the neonate

1991 ◽  
Vol 10 ◽  
pp. 4
Author(s):  
S. Blazer ◽  
G.T. Reinersman ◽  
T. Manner ◽  
J. Askanazi ◽  
P. Furst ◽  
...  
Keyword(s):  
Amino Acids ◽  
Branched Chain Amino Acids ◽  
Respiratory Pattern ◽  
Branched Chain ◽  
And Function

scholarly journals Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids

2019 ◽  
Vol 316 (1) ◽  
pp. E73-E85 ◽  
Author(s):  
Shi-Jun Yue ◽  
Juan Liu ◽  
Ai-Ting Wang ◽  
Xin-Tong Meng ◽  
Zhi-Rui Yang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Amino Acids ◽  
Gut Microbiota ◽  
Ex Vivo ◽  
Elevated Serum ◽  
Branched Chain Amino Acids ◽  
Chow Diet ◽  
Adipose Tissues ◽  
Branched Chain ◽  
Ketoacid Dehydrogenase

Increased circulating branched-chain amino acids (BCAAs) have been involved in the pathogenesis of obesity and insulin resistance (IR). However, evidence relating berberine (BBR), gut microbiota, BCAAs, and IR is limited. Here, we showed that BBR could effectively rectify steatohepatitis and glucose intolerance in high-fat diet (HFD)-fed mice. BBR reorganized gut microbiota populations under both the normal chow diet (NCD) and HFD. Particularly, BBR noticeably decreased the relative abundance of BCAA-producing bacteria, including order Clostridiales; families Streptococcaceae, Clostridiaceae, and Prevotellaceae; and genera Streptococcus and Prevotella. Compared with the HFD group, predictive metagenomics indicated a reduction in the proportion of gut microbiota genes involved in BCAA biosynthesis but the enrichment genes for BCAA degradation and transport by BBR treatment. Accordingly, the elevated serum BCAAs of HFD group were significantly decreased by BBR. Furthermore, the Western blotting results implied that BBR could promote the BCAA catabolism in the liver and epididymal white adipose tissues of HFD-fed mice by activation of the multienzyme branched-chain α-ketoacid dehydrogenase complex (BCKDC), whereas by inhibition of the phosphorylation state of BCKDHA (E1α subunit) and branched-chain α-ketoacid dehydrogenase kinase (BCKDK). The ex vivo assay further confirmed that BBR could increase BCAA catabolism in both AML12 hepatocytes and 3T3-L1 adipocytes. Finally, data from healthy subjects and diabetics confirmed that BBR could improve glycemic control and modulate circulating BCAAs. Together, our findings clarified BBR improving IR associated not only with gut microbiota alteration in BCAA biosynthesis but also with BCAA catabolism in liver and adipose tissues.

Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a double-blind, randomized trial

2003 ◽  
Vol 124 (7) ◽  
pp. 1792-1801 ◽  
Author(s):  
Giulio Marchesini ◽  
Giampaolo Bianchi ◽  
Manuela Merli ◽  
Piero Amodio ◽  
Carmine Panella ◽  
...  
Keyword(s):  
Amino Acids ◽  
Randomized Trial ◽  
Branched Chain Amino Acids ◽  
Nutritional Supplementation ◽  
Double Blind ◽  
Advanced Cirrhosis ◽  
Branched Chain

The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

2018 ◽  
Vol 88 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
Zahra Shakibay Novin ◽  
Saeed Ghavamzadeh ◽  
Alireza Mehdizadeh
Keyword(s):  
Amino Acids ◽  
Weight Loss ◽  
Body Composition ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Waist To Hip Ratio ◽  
Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

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