scholarly journals Things that go BMP in the liver: Bone morphogenetic protein 6 and the control of body iron homeostasis

Hepatology ◽  
2009 ◽  
Vol 50 (1) ◽  
pp. 316-319 ◽  
Author(s):  
Gregory J. Anderson
Keyword(s):  
Bone Morphogenetic Protein ◽  
Iron Homeostasis ◽  
Body Iron ◽  
Morphogenetic Protein ◽  
Bone Morphogenetic Protein 6

scholarly journals Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

Blood ◽  
2017 ◽  
Vol 129 (4) ◽  
pp. 405-414 ◽  
Author(s):  
Susanna Canali ◽  
Kimberly B. Zumbrennen-Bullough ◽  
Amanda B. Core ◽  
Chia-Yu Wang ◽  
Manfred Nairz ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Bone Morphogenetic Protein ◽  
Knockout Mice ◽  
Iron Homeostasis ◽  
Conditional Knockout ◽  
Conditional Knockout Mice ◽  
Morphogenetic Protein ◽  
Key Points ◽  
Paracrine Actions ◽  
Bone Morphogenetic Protein 6

Key Points Endothelial Bmp6 conditional knockout mice exhibit hemochromatosis, whereas hepatocyte and macrophage Bmp6 conditional knockout mice do not. Our data support a model in which EC Bmp6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin production.

scholarly journals Bone Morphogenetic Protein 6 Polymorphisms Are Associated with Radiographic Progression in Ankylosing Spondylitis

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104966 ◽  
Author(s):  
Young Bin Joo ◽  
So-Young Bang ◽  
Tae-Hwan Kim ◽  
Seung-Cheol Shim ◽  
Seunghun Lee ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Bone Morphogenetic Protein ◽  
Radiographic Progression ◽  
Morphogenetic Protein ◽  
Bone Morphogenetic Protein 6

scholarly journals Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation

2020 ◽  
Vol 84 ◽  
pp. 102444
Author(s):  
Aline Morgan Alvarenga ◽  
Nathália Kozikas da Silva ◽  
Paula Fernanda Silva Fonseca ◽  
Theo G.M. Oliveira ◽  
Jacilene Barbosa da Silva Monteiro ◽  
...  
Keyword(s):  
Iron Overload ◽  
Bone Morphogenetic Protein ◽  
Novel Mutations ◽  
Morphogenetic Protein ◽  
Homozygous Genotype ◽  
Bone Morphogenetic Protein 6

scholarly journals Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

Blood ◽  
2011 ◽  
Vol 117 (18) ◽  
pp. 4915-4923 ◽  
Author(s):  
Andrea U. Steinbicker ◽  
Chetana Sachidanandan ◽  
Ashley J. Vonner ◽  
Rushdia Z. Yusuf ◽  
Donna Y. Deng ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Iron Homeostasis ◽  
Iron Bioavailability ◽  
Bmp Signaling ◽  
Neoplastic Disease ◽  
Type I ◽  
Hepcidin Expression ◽  
Hepatic Expression ◽  
Morphogenetic Protein ◽  
Anemia Of Inflammation

Abstract Anemia of inflammation develops in settings of chronic inflammatory, infectious, or neoplastic disease. In this highly prevalent form of anemia, inflammatory cytokines, including IL-6, stimulate hepatic expression of hepcidin, which negatively regulates iron bioavailability by inactivating ferroportin. Hepcidin is transcriptionally regulated by IL-6 and bone morphogenetic protein (BMP) signaling. We hypothesized that inhibiting BMP signaling can reduce hepcidin expression and ameliorate hypoferremia and anemia associated with inflammation. In human hepatoma cells, IL-6–induced hepcidin expression, an effect that was inhibited by treatment with a BMP type I receptor inhibitor, LDN-193189, or BMP ligand antagonists noggin and ALK3-Fc. In zebrafish, the induction of hepcidin expression by transgenic expression of IL-6 was also reduced by LDN-193189. In mice, treatment with IL-6 or turpentine increased hepcidin expression and reduced serum iron, effects that were inhibited by LDN-193189 or ALK3-Fc. Chronic turpentine treatment led to microcytic anemia, which was prevented by concurrent administration of LDN-193189 or attenuated when LDN-193189 was administered after anemia was established. Our studies support the concept that BMP and IL-6 act together to regulate iron homeostasis and suggest that inhibition of BMP signaling may be an effective strategy for the treatment of anemia of inflammation.

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