scholarly journals Liver biopsy in hepatitis C virus carriers with normal alanine aminotransferase levels

Hepatology ◽  
2009 ◽  
Vol 50 (2) ◽  
pp. 655-655 ◽  
Author(s):  
Laudio Puoti ◽  
Lia Bellis ◽  
Riccardo Guarisco
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Biopsy ◽  
Alanine Aminotransferase ◽  
Normal Alanine Aminotransferase

scholarly journals Clinical Features of Hepatitis C Virus Carriers With Persistently normal Alanine Aminotransferase Levels

2012 ◽  
Vol 12 (2) ◽  
pp. 77-84 ◽  
Author(s):  
Hirofumi Uto ◽  
Seiich Mawatari ◽  
Kotaro Kumagai ◽  
Akio Ido ◽  
Hirohito Tsubouchi
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Clinical Features ◽  
Alanine Aminotransferase ◽  
Normal Alanine Aminotransferase

Impaired Function of Dendritic Cells Circulating in Patients Infected with Hepatitis C Virus Who Have Persistently Normal Alanine Aminotransferase Levels

Intervirology ◽  
2005 ◽  
Vol 49 (1-2) ◽  
pp. 58-63 ◽  
Author(s):  
Tatsuya Kanto ◽  
Michiyo Inoue ◽  
Masanori Miyazaki ◽  
Ichiyo Itose ◽  
Hideki Miyatake ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Alanine Aminotransferase ◽  
Impaired Function ◽  
Normal Alanine Aminotransferase

scholarly journals Evidence for Viral Persistence in Patients Who Test Positive for Anti–Hepatitis C Virus Antibodies and Have Normal Alanine Aminotransferase Levels

2005 ◽  
Vol 191 (10) ◽  
pp. 1730-1733 ◽  
Author(s):  
Marek Radkowski ◽  
Andrzej Horban ◽  
Juan F. Gallegos‐Orozco ◽  
Agnieszka Pawelczyk ◽  
Joanna Jablonska ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Alanine Aminotransferase ◽  
Viral Persistence ◽  
Normal Alanine Aminotransferase

Treatment of hepatitis C virus carriers with persistently normal alanine aminotransferase levels with peginterferon α-2a and ribavirin: a multicentric study

2009 ◽  
Vol 29 (10) ◽  
pp. 1479-1484 ◽  
Author(s):  
Claudio Puoti ◽  
Adriano M. Pellicelli ◽  
Mario Romano ◽  
Fabrizio Mecenate ◽  
Riccardo Guarisco ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Alanine Aminotransferase ◽  
Multicentric Study ◽  
Normal Alanine Aminotransferase ◽  
Peginterferon Α

Liver Histology of Patients with Hepatitis C Virus Infection and Normal Alanine Aminotransferase Levels

2012 ◽  
Vol 25 (1) ◽  
pp. 19-23
Author(s):  
Bilgehan Aygen ◽  
Kemal Deniz ◽  
Sila Akhan ◽  
Mustafa Kemal Celen ◽  
Orhan Yildiz ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Alanine Aminotransferase ◽  
Liver Histology ◽  
Hepatitis C Virus Infection ◽  
Normal Alanine Aminotransferase

scholarly journals Liver fibrosis progression in HIV/hepatitis C virus coinfected patients with normal aminotransferases levels

2012 ◽  
Vol 45 (4) ◽  
pp. 444-447 ◽  
Author(s):  
Fábio Heleno de Lima Pace ◽  
Lincoln Eduardo Vieira de Castro Ferreira ◽  
Antonio Eduardo Benedito Silva ◽  
Maria Lucia Gomes Ferraz
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Liver Biopsy ◽  
Hepatitis B Surface Antigen ◽  
Hcv Rna ◽  
Progression Rate ◽  
Fibrosis Progression ◽  
Normal Alanine Aminotransferase ◽  
Normal Alt

INTRODUCTION: Approximately 30% of hepatitis C virus (HCV) monoinfected patients present persistently normal alanine aminotransferase (ALT) levels. Most of these patients have a slow progression of liver fibrosis. Studies have demonstrated the rate of liver fibrosis progression in hepatitis C virus-human immunodeficiency virus (HCV-HIV) coinfected patients is faster than in patients infected only by HCV. Few studies have evaluated the histological features of chronic hepatitis C in HIV-infected patients with normal ALT levels. METHODS: HCV-HIV coinfected patients (HCV-RNA and anti-HIV positive) with known time of HCV infection (intravenous drugs users) were selected. Patients with hepatitis B surface antigen (HBsAg) positive or hepatitis C treatment before liver biopsy were excluded. Patients were considered to have a normal ALT levels if they had at least 3 normal determinations in the previous 6 months prior to liver biopsy. All patients were submitted to liver biopsy and METAVIR scale was used. RESULTS: Of 50 studied patients 40 (80%) were males. All patients were treated with antiretroviral therapy. The ALT levels were normal in 13 (26%) patients. HCV-HIV co-infected patients with normal ALT levels had presented means of the liver fibrosis stages (0.77±0.44 versus 1.86±1.38; p<0.001) periportal inflammatory activity (0.62±0.77 versus 2.24±1.35; p<0.001) and liver fibrosis progression rate (0.058±0.043 fibrosis unit/year versus 0.118±0.102 fibrosis unit/year) significantly lower as compared to those with elevated ALT. CONCLUSIONS: HCV-HIV coinfected patients with persistently normal ALTs showed slower progression of liver fibrosis. In these patients the development of liver cirrhosis is improbable.

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