scholarly journals Phenotypic characterization of idiosyncratic drug-induced liver injury: The influence of age and sex

Hepatology ◽  
2009 ◽  
Vol 49 (6) ◽  
pp. 2001-2009 ◽  
Author(s):  
M. Isabel Lucena ◽  
Raúl J. Andrade ◽  
Neil Kaplowitz ◽  
Miren García-Cortes ◽  
M. Carmen Fernández ◽  
...  
Keyword(s):  
Liver Injury ◽  
Phenotypic Characterization ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Age And Sex

scholarly journals Characterization of patients diagnosed with drug-induced liver injury

2021 ◽  
pp. 036-040
Author(s):  
Ashkenazi Itay ◽  
Lurie Yoav ◽  
Kenig Ariel ◽  
Zevin Shoshana ◽  
Gafanovich Ina ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Catherine C. Bell ◽  
Delilah F. G. Hendriks ◽  
Sabrina M. L. Moro ◽  
Ewa Ellis ◽  
Joanne Walsh ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Model System ◽  
Human Hepatocyte ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Primary Human Hepatocyte ◽  
Hepatocyte Spheroids

1089 CHARACTERIZATION OF STEROID THERAPY FOR DRUG-INDUCED LIVER INJURY

2020 ◽  
Vol 158 (6) ◽  
pp. S-1304
Author(s):  
Jiayi Ma ◽  
Jiezhun Gu ◽  
Craig Lammert ◽  
Raj Vuppalanchi ◽  
Naga P. Chalasani ◽  
...  
Keyword(s):  
Liver Injury ◽  
Steroid Therapy ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury

2021 ◽  
Vol 70 ◽  
pp. 105010
Author(s):  
Manisha Nautiyal ◽  
Rani J. Qasem ◽  
John K. Fallon ◽  
Kristina K. Wolf ◽  
Jingli Liu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Model System ◽  
Drug Induced ◽  
Mouse Hepatocyte ◽  
Drug Induced Liver Injury ◽  
Primary Mouse ◽  
Hepatocyte Spheroids ◽  
Primary Mouse Hepatocyte

scholarly journals Characterization of patients diagnosed with drug-induced liver injury

2020 ◽  
Author(s):  
Itay Ashkenazi ◽  
Yoav Lurie ◽  
Shoshana Zevin ◽  
Ariel Kenig ◽  
Ina Gafanovich ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Critical Review of Gaps in the Diagnosis and Management of Drug-Induced Liver Injury Associated with Severe Cutaneous Adverse Reactions

2021 ◽  
Vol 10 (22) ◽  
pp. 5317
Author(s):  
Marina Villanueva-Paz ◽  
Hao Niu ◽  
Antonio Segovia-Zafra ◽  
Inmaculada Medina-Caliz ◽  
Judith Sanabria-Cabrera ◽  
...  
Keyword(s):  
Liver Injury ◽  
Adverse Reactions ◽  
Randomized Clinical Trials ◽  
Skin Injury ◽  
Drug Induced ◽  
Cutaneous Manifestations ◽  
Drug Induced Liver Injury ◽  
Complex Disorder ◽  
Cutaneous Adverse Reactions

Drug-induced liver injury (DILI) encompasses the unexpected damage that drugs can cause to the liver. DILI may develop in the context of an immunoallergic syndrome with cutaneous manifestations, which are sometimes severe (SCARs). Nevirapine, allopurinol, anti-epileptics, sulfonamides, and antibiotics are the most frequent culprit drugs for DILI associated with SCARs. Interestingly, alleles HLA-B*58:01 and HLA-A*31:01 are associated with both adverse reactions. However, there is no consensus about the criteria used for the characterization of liver injury in this context, and the different thresholds for DILI definition make it difficult to gain insight into this complex disorder. Moreover, current limitations when evaluating causality in patients with DILI associated with SCARs are related to the plethora of causality assessment methods and the lack of consensual complementary tools. Finally, the management of this condition encompasses the treatment of liver and skin injury. Although the use of immunomodulant agents is accepted for SCARs, their role in treating liver injury remains controversial. Further randomized clinical trials are needed to test their efficacy and safety to address this complex entity. Therefore, this review aims to identify the current gaps in the definition, diagnosis, prognosis, and management of DILI associated with SCARs, proposing different strategies to fill in these gaps.

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

2011 ◽  
Vol 128 (3) ◽  
pp. 680-683.e5 ◽  
Author(s):  
Sabah El-Ghaiesh ◽  
Joseph P. Sanderson ◽  
John Farrell ◽  
Sidonie N. Lavergne ◽  
Wing-Kin Syn ◽  
...  
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Lymphocyte Responses

Leberschaden unter oraler Antikoagulation, Statin- und ACE-Hemmertherapie

Praxis ◽  
2010 ◽  
Vol 99 (21) ◽  
pp. 1259-1265 ◽  
Author(s):  
Bruggisser ◽  
Terraciano ◽  
Rätz Bravo ◽  
Haschke
Keyword(s):  
Liver Injury ◽  
Wird Eine ◽  
Drug Induced ◽  
Drug Induced Liver Injury

Ein 71-jähriger Patient stellt sich mit Epistaxis und ikterischen Skleren auf der Notfallstation vor. Der Patient steht unter einer Therapie mit Phenprocoumon, Atorvastatin und Perindopril. Anamnestisch besteht ein langjähriger Alkoholabusus. Laborchemisch werden massiv erhöhte Leberwerte (ALAT, Bilirubin) gesehen. Der INR ist unter oraler Antikoagulation und bei akuter Leberinsuffizienz >12. Die weiterführenden Abklärungen schliessen eine Virushepatitis und eine Autoimmunhepatitis aus. Nachdem eine Leberbiopsie durchgeführt werden kann, wird eine medikamentös-toxische Hepatitis, ausgelöst durch die Komedikation von Atorvastatin, Phenprocoumon und Perindopril bei durch Alkohol bereits vorgeschädigter Leber diagnostiziert. Epidemiologie, Pathophysiologie und Klink der medikamentös induzierten Leberschäden (drug induced liver injury, DILI), speziell von Coumarinen, Statinen und ACE-Hemmern werden im Anschluss an den Fallbericht diskutiert.

Drug-induced liver injury network (DILIN)

Hepatology ◽  
2004 ◽  
Vol 40 (4) ◽  
pp. 773-773 ◽  
Author(s):  
Jay H. Hoofnagle
Keyword(s):  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury
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