Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor β actions in hepatocytes-But without modulating bone morphogenetic protein 7 signaling

Olav A. Gressner; Birgit Lahme; Monika Siluschek; Katharina Rehbein; Ralf Weiskirchen; Axel M. Gressner

doi:10.1002/hep.22850

Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor β actions in hepatocytes-But without modulating bone morphogenetic protein 7 signaling

Hepatology ◽

10.1002/hep.22850 ◽

2009 ◽

Vol 49 (6) ◽

pp. 2021-2030 ◽

Cited By ~ 35

Author(s):

Olav A. Gressner ◽

Birgit Lahme ◽

Monika Siluschek ◽

Katharina Rehbein ◽

Ralf Weiskirchen ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Bone Morphogenetic Protein ◽

Connective Tissue Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Bone Morphogenetic Protein 7 ◽

Morphogenetic Protein

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Bone Morphogenetic Protein-7 and Connective Tissue Growth Factor: Novel Targets for Treatment of Renal Fibrosis?

Pharmaceutical Research ◽

10.1007/s11095-008-9548-9 ◽

2008 ◽

Vol 25 (10) ◽

pp. 2416-2426 ◽

Cited By ~ 57

Author(s):

Tri Q. Nguyen ◽

Roel Goldschmeding

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Bone Morphogenetic Protein ◽

Connective Tissue Growth Factor ◽

Renal Fibrosis ◽

Tissue Growth ◽

Bone Morphogenetic Protein 7 ◽

Morphogenetic Protein ◽

Novel Targets

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Connective Tissue Growth Factor (CTGF/CCN2) is a Direct Transcriptional Target of SOX2 and Regulator of Integrin Alpha 5, Bone Morphogenetic Protein 7, and Collagen I Alpha 1 Expression in Squamous Cell Lung Cancer

Journal of Surgical Research ◽

10.1016/j.jss.2013.11.947 ◽

2014 ◽

Vol 186 (2) ◽

pp. 683

Author(s):

M.K. Mallipeddi ◽

J.M. Hanna ◽

C.R. Futtner ◽

M.W. Onaitis

Keyword(s):

Lung Cancer ◽

Growth Factor ◽

Connective Tissue ◽

Bone Morphogenetic Protein ◽

Connective Tissue Growth Factor ◽

Squamous Cell ◽

Tissue Growth ◽

Bone Morphogenetic Protein 7 ◽

Morphogenetic Protein ◽

Transcriptional Target

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Connective tissue growth factor mediates the profibrotic effects of transforming growth factor-β produced by tubular epithelial cells in response to high glucose

Clinical and Experimental Nephrology ◽

10.1007/s10157-005-0347-x ◽

2005 ◽

Vol 9 (2) ◽

pp. 114-121 ◽

Cited By ~ 34

Author(s):

Tatsuya Kobayashi ◽

Tsutomu Inoue ◽

Hirokazu Okada ◽

Tomohiro Kikuta ◽

Yoshihiko Kanno ◽

...

Keyword(s):

Growth Factor ◽

Epithelial Cells ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

High Glucose ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Tubular Epithelial Cells

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Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes

PLoS ONE ◽

10.1371/journal.pone.0046526 ◽

2012 ◽

Vol 7 (10) ◽

pp. e46526 ◽

Cited By ~ 21

Author(s):

Tirumuru Nagaraja ◽

Li Chen ◽

Anuradha Balasubramanian ◽

Jerome E. Groopman ◽

Kalpana Ghoshal ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth

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Hepatocyte growth factor counteracts transforming growth factor‐β 1 , through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice

The FASEB Journal ◽

10.1096/fj.02-0442fje ◽

2002 ◽

Vol 17 (2) ◽

pp. 268-270 ◽

Cited By ~ 101

Author(s):

Tsutomu Inoue ◽

Hirokazu Okada ◽

Tatsuya Kobayashi ◽

Yusuke Watanabe ◽

Yoshihiko Kanno ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Hepatocyte Growth Factor ◽

Connective Tissue Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Renal Fibrogenesis ◽

Hepatocyte Growth

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Transforming growth factor-β/connective tissue growth factor axis in the kidney

The International Journal of Biochemistry & Cell Biology ◽

10.1016/j.biocel.2007.01.006 ◽

2008 ◽

Vol 40 (1) ◽

pp. 9-13 ◽

Cited By ~ 65

Author(s):

Weier Qi ◽

Xinming Chen ◽

Philip Poronnik ◽

Carol A. Pollock

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth

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Bone morphogenetic protein-7 in focus: A member of the transforming growth factor-β superfamily is implicated in the maintenance of liver health

Hepatology ◽

10.1002/hep.21694 ◽

2007 ◽

Vol 45 (5) ◽

pp. 1324-1325 ◽

Cited By ~ 2

Author(s):

Ralf Weiskirchen ◽

Steffen K. Meurer

Keyword(s):

Growth Factor ◽

Bone Morphogenetic Protein ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Bone Morphogenetic Protein 7 ◽

Morphogenetic Protein ◽

Liver Health

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Connective tissue growth factor mediates transforming growth factor β-induced collagen expression in human endometrial stromal cells

PLoS ONE ◽

10.1371/journal.pone.0210765 ◽

2019 ◽

Vol 14 (1) ◽

pp. e0210765 ◽

Cited By ~ 7

Author(s):

Mei-Leng Cheong ◽

Tsung-Hsuan Lai ◽

Wen-Bin Wu

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Stromal Cells ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Endometrial Stromal Cells ◽

Collagen Expression

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Profibrogenic transforming growth factor-β/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes

Hepatology ◽

10.1002/hep.21806 ◽

2007 ◽

Vol 46 (4) ◽

pp. 1257-1270 ◽

Cited By ~ 78

Author(s):

Hong-Lei Weng ◽

Loredana Ciuclan ◽

Yan Liu ◽

Jafar Hamzavi ◽

Patricio Godoy ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Activin Receptor ◽

Receptor Like Kinase ◽

Factor Expression ◽

Growth Factor Expression

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Role of connective tissue growth factor in profibrotic action of transforming growth factor-β: A potential target for preventing renal fibrosis

American Journal of Kidney Diseases ◽

10.1053/ajkd.2001.27422 ◽

2001 ◽

Vol 38 (4) ◽

pp. S134-S138 ◽

Cited By ~ 108

Author(s):

Hideki Yokoi ◽

Akira Sugawara ◽

Masashi Mukoyama ◽

Kiyoshi Mori ◽

Hisashi Makino ◽

...

Keyword(s):

Growth Factor ◽

Connective Tissue ◽

Connective Tissue Growth Factor ◽

Renal Fibrosis ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tissue Growth ◽

Potential Target

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