scholarly journals Hepatitis B virus suppresses toll-like receptor-mediated innate immune responses in murine parenchymal and nonparenchymal liver cells

Hepatology ◽  
2008 ◽  
Vol 49 (4) ◽  
pp. 1132-1140 ◽  
Author(s):  
Jun Wu ◽  
Zhongji Meng ◽  
Min Jiang ◽  
Rongjuan Pei ◽  
Martin Trippler ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Liver Cells ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
B Virus

Hepatitis B virus does not suppress the innate immune responses in the liver

2017 ◽  
Vol 66 (1) ◽  
pp. S28
Author(s):  
A. Suslov ◽  
D. Calabrese ◽  
T. Boldanova ◽  
S. Wieland ◽  
M. Heim
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
B Virus

scholarly journals Hepatitis B Virus Does Not Interfere With Innate Immune Responses in the Human Liver

2018 ◽  
Vol 154 (6) ◽  
pp. 1778-1790 ◽  
Author(s):  
Aleksei Suslov ◽  
Tujana Boldanova ◽  
Xueya Wang ◽  
Stefan Wieland ◽  
Markus H. Heim
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Human Liver ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
B Virus

scholarly journals Hepatitis B Virus–Hepatocyte Interactions and Innate Immune Responses: Experimental Models and Molecular Mechanisms

2019 ◽  
Vol 39 (03) ◽  
pp. 301-314 ◽  
Author(s):  
Emmanuel Thomas ◽  
Thomas F. Baumert
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Responses ◽  
Viral Infection ◽  
Signaling Pathways ◽  
Viral Pathogenesis ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Host Interactions ◽  
B Virus

AbstractChronic hepatitis B virus (HBV) infection is a major cause of liver disease and cancer worldwide. While current therapeutic approaches can efficiently control viral infection, efficient curative antivirals are absent. The understanding of virus–hepatocyte interactions and sensing of viral infection is an important prerequisite for the development of novel antiviral therapies for cure. Hepatocyte intrinsic innate immunity provides a rapid first line of defense to combat viral infection through the upregulation of antiviral and inflammatory genes. However, the functional relevance of many of these antiviral signaling pathways in the liver and their role in HBV pathogenesis is still only partially understood. The recent identification of intracellular RNA and DNA sensing pathways and their involvement in disease biology, including viral pathogenesis and carcinogenesis, is currently transforming our understanding of virus–host interactions. Here the authors review the current knowledge on intrinsic antiviral innate immune responses including the role of viral nucleic acid sensing pathways in the liver. Since HBV has been designated as a “stealth virus,” the study of the impact of HBV on signaling pathways in the hepatocyte is of significant interest to understand viral pathogenesis. Characterizing the mechanism underlying these HBV–host interactions and targeting related pathways to enhance antiviral innate responses may open new strategies to trigger noncytopathic clearance of covalently closed circular DNA to ultimately cure patients with chronic HBV infection.

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