scholarly journals CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-β-induced apoptosis

Hepatology ◽  
2008 ◽  
Vol 49 (4) ◽  
pp. 1277-1286 ◽  
Author(s):  
Wei Ding ◽  
Marialena Mouzaki ◽  
Hanning You ◽  
Joshua C. Laird ◽  
Jose Mato ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Transforming Growth Factor ◽  
Liver Cancer Stem Cells ◽  
Induced Apoptosis ◽  
Deficient Mice ◽  
Methionine Adenosyl Transferase

scholarly journals Transforming growth factor-β in liver cancer stem cells and regeneration

2017 ◽  
Vol 1 (6) ◽  
pp. 477-493 ◽  
Author(s):  
Shuyun Rao ◽  
Sobia Zaidi ◽  
Jaideep Banerjee ◽  
Wilma Jogunoori ◽  
Raul Sebastian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Liver Cancer Stem Cells

scholarly journals Knockdown of 14-3-3ζ enhances radiosensitivity and radio-induced apoptosis in CD133+ liver cancer stem cells

2014 ◽  
Vol 46 (2) ◽  
pp. e77-e77 ◽  
Author(s):  
Young Ki Lee ◽  
Wonhee Hur ◽  
Sung Won Lee ◽  
Sung Woo Hong ◽  
Sung Woo Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Liver Cancer Stem Cells ◽  
Induced Apoptosis

scholarly journals Knockdown of miR-25 increases the sensitivity of liver cancer stem cells to TRAIL-induced apoptosis via PTEN/PI3K/Akt/Bad signaling pathway

2016 ◽  
Vol 49 (6) ◽  
pp. 2600-2610 ◽  
Author(s):  
Xiaoning Feng ◽  
Jingjin Jiang ◽  
Shaohua Shi ◽  
Haiyang Xie ◽  
Lin Zhou ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Signaling Pathway ◽  
Liver Cancer Stem Cells ◽  
Induced Apoptosis

scholarly journals Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice

Hepatology ◽  
2007 ◽  
Vol 47 (4) ◽  
pp. 1288-1297 ◽  
Author(s):  
C. Bart Rountree ◽  
Shantha Senadheera ◽  
Jose M. Mato ◽  
Gay M. Crooks ◽  
Shelly C. Lu
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Methionine Adenosyltransferase ◽  
Liver Cancer Stem Cells ◽  
Deficient Mice

scholarly journals The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wang Yin ◽  
Dongxi Xiang ◽  
Tao Wang ◽  
Yumei Zhang ◽  
Cuong V. Pham ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
High Performance ◽  
Annexin V ◽  
Intracellular Concentration ◽  
Liver Cancer Stem Cells ◽  
Chemotherapy Agent ◽  
Future Strategy ◽  
Annexin V Assay

AbstractTwo ATP-binding cassette transporters, ABCB1/MDR1 and ABCG2/BCRP, are considered the most critical determinants for chemoresistance in hepatocellular carcinoma. However, their roles in the chemoresistance in liver cancer stem cells remain elusive. Here we explored the role of inhibition of MDR1 or ABCG2 in sensitizing liver cancer stem cells to doxorubicin, the most frequently used chemotherapeutic agent in treating liver cancer. We show that the inhibition of MDR1 or ABCG2 in Huh7 and PLC/PRF/5 cells using either pharmacological inhibitors or RNAi resulted in the elevated level of intracellular concentration of doxorubicin and the accompanied increased apoptosis as determined by confocal microscopy, high-performance liquid chromatography, flow cytometry, and annexin V assay. Notably, the inhibition of MDR1 or ABCG2 led to the reversal of the chemoresistance, as evident from the enhanced death of the chemoresistant liver cancer stem cells in tumorsphere-forming assays. Thus, the elevation of effective intracellular concentration of doxorubicin via the inhibition of MDR1 or ABCG2 represents a promising future strategy that transforms doxorubicin from a traditional chemotherapy agent into a robust killer of liver cancer stem cells for patients undergoing transarterial chemoembolization.

MK2206 overcomes the resistance of human liver cancer stem cells to sorafenib by inhibition of pAkt and upregulation of pERK

Tumor Biology ◽  
2015 ◽  
Vol 37 (6) ◽  
pp. 8047-8055 ◽  
Author(s):  
Beibei Zhai ◽  
Xiaofeng Zhang ◽  
Bin Sun ◽  
Lu Cao ◽  
Linlin Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Liver Cancer ◽  
Human Liver ◽  
Liver Cancer Stem Cells ◽  
Human Liver Cancer
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