Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir

Hepatology ◽  
2008 ◽  
Vol 49 (1) ◽  
pp. 72-79 ◽  
Author(s):  
Nancy Leung ◽  
Cheng-Yuan Peng ◽  
Hie-Won Hann ◽  
Jose Sollano ◽  
Judy Lao-Tan ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
International Study ◽  
Hepatitis B E Antigen ◽  
Hepatitis B Virus Dna ◽  
B Virus ◽  
Dna Reduction

Treatment With Interferon Gamma Versus Interferons Alfa and Gamma in Children With Chronic Hepatitis B

PEDIATRICS ◽  
1992 ◽  
Vol 90 (2) ◽  
pp. 254-258
Author(s):  
Mercedes Ruiz-Moreno ◽  
Maria Jose Rúa ◽  
Gloria Moraleda ◽  
Leonor Guardia ◽  
Alberto Moreno ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Interferon Gamma ◽  
Antiviral Effect ◽  
Control Group ◽  
Hepatitis B E Antigen ◽  
Hepatitis B Virus Dna ◽  
B Virus

Thirty-five children with chronic hepatitis B were randomly assigned to three groups: group 1 (n = 12), untreated group 2 (n = 11), treated with 1 million units of Interferon gamma per square meter of body surface (MU/m2), three times a week for 24 weeks; and group 3 (n = 12), treated with interferon alfa at a dose of 5 MU/m2, three times a week for 12 weeks followed by 1 MU/m2 of interferon gamma with the same schedule. At the end of the treatment (6th month), hepatitis B virus DNA was negative in 16.5% of the control group, in 9% of the children treated with interferon gamma, and in 16.5% of those treated with interferons alfa and gamma. No child had lost the hepatitis B e antigen by this time. No basal differences in the serum hepatitis B virus DNA concentration among the groups were observed. At follow-up (15th month), viral genome was negative in 25% of the untreated children, in 36% of the group treated with interferon gamma, and in 41.5% of the children who had received interferons alfa and gamma. Hepatitis B e antigen was negative in 25% of the children who belonged to groups 1 and 3 and in 27% of the children treated with interferon gamma only. These data suggest that interferon gamma does not have a powerful antiviral effect on chronic hepatitis B in children. However, it is well tolerated.

Hepatitis B virus DNA prediction rules for hepatitis B e antigen–negative chronic hepatitis B

Hepatology ◽  
2007 ◽  
Vol 46 (4) ◽  
pp. 1057-1070 ◽  
Author(s):  
Jordan J. Feld ◽  
Melissa Ayers ◽  
Dahlia El-Ashry ◽  
Tony Mazzulli ◽  
Raymond Tellier ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B E Antigen ◽  
Prediction Rules ◽  
Hepatitis B Virus Dna ◽  
B Virus ◽  
Negative Chronic Hepatitis

Hepatitis B virus DNA levels and outcomes in chronic hepatitis B

Hepatology ◽  
2009 ◽  
Vol 49 (S5) ◽  
pp. S72-S84 ◽  
Author(s):  
Chien-Jen Chen ◽  
Hwai-I Yang ◽  
Uchenna H. Iloeje ◽  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Virus Dna ◽  
B Virus
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