scholarly journals Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

Hepatology ◽  
2008 ◽  
Vol 49 (1) ◽  
pp. 297-305 ◽  
Author(s):  
Kwang-Hoon Song ◽  
Tiangang Li ◽  
Erika Owsley ◽  
Stephen Strom ◽  
John Y. L. Chiang
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Human Hepatocytes ◽  
Fibroblast Growth ◽  
Hydroxylase Gene ◽  
Fibroblast Growth Factor 19

443 Association of GPBAR1 Gene Variant With Satiation and Circulating Fibroblast Growth Factor-19 Supports a Role of Bile Acids in Obesity

2015 ◽  
Vol 81 (5) ◽  
pp. AB146-AB147
Author(s):  
Andres Acosta ◽  
Nelson Valentin Feliciano ◽  
Paula Carlson ◽  
Deborah J. Eckert ◽  
Jessica O'Neill ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Gene Variant ◽  
Fibroblast Growth Factor 19

Sa1303 Dramatic Stimulation of Fibroblast Growth Factor 19 Expression in the Human Ileum by Bile Acids

2012 ◽  
Vol 142 (5) ◽  
pp. S-268
Author(s):  
Justine H. Zhang ◽  
Jonathan D. Nolan ◽  
Ian Johnston ◽  
Sarah Kennie ◽  
Tracy Dew ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19 ◽  
Stimulation Of

scholarly journals A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass

Diabetes Care ◽  
2013 ◽  
Vol 36 (7) ◽  
pp. 1859-1864 ◽  
Author(s):  
G. S. Gerhard ◽  
A. M. Styer ◽  
G. C. Wood ◽  
S. L. Roesch ◽  
A. T. Petrick ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Diabetes Remission ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

443 Association of GPBAR1 Gene Variant With Satiation and Circulating Fibroblast Growth Factor-19 Supports a Role of Bile Acids in Obesity

2015 ◽  
Vol 148 (4) ◽  
pp. S-92-S-93
Author(s):  
Andres Acosta ◽  
Nelson Valentin Feliciano ◽  
Paula Carlson ◽  
Deborah J. Eckert ◽  
Jessica O'Neill ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bile Acids ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Gene Variant ◽  
Fibroblast Growth Factor 19

scholarly journals Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes

2021 ◽  
Vol 11 ◽  
Author(s):  
Helene Johansson ◽  
Jonas Nørskov Søndergaard ◽  
Carl Jorns ◽  
Claudia Kutter ◽  
Ewa C. S. Ellis
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Chenodeoxycholic Acid ◽  
Regulatory Protein ◽  
Human Hepatocytes ◽  
Fibroblast Growth ◽  
Independent Manner ◽  
Primary Human Hepatocytes ◽  
Fibroblast Growth Factor 19 ◽  
The Impact

Bile acids (BAs) are detergents essential for intestinal absorption of lipids. Disruption of BA homeostasis can lead to severe liver damage. BA metabolism is therefore under strict regulation by sophisticated feedback mechanisms. The hormone-like protein Fibroblast growth factor 19 (FGF19) is essential for maintaining BA homeostasis by down regulating BA synthesis. Here, the impact of both FGF19 and chenodeoxycholic acid (CDCA) on primary human hepatocytes was investigated and a possible autocrine/paracrine function of FGF19 in regulation of BA synthesis evaluated. Primary human hepatocytes were treated with CDCA, recombinant FGF19 or conditioned medium containing endogenously produced FGF19. RNA sequencing revealed that treatment with CDCA causes deregulation of transcripts involved in BA metabolism, whereas treatment with FGF19 had minor effects. CDCA increased FGF19 mRNA expression within 1 h. We detected secretion of the resulting FGF19 protein into medium, mimicking in vivo observations. Furthermore, medium enriched with endogenously produced FGF19 reduced BA synthesis by down regulating CYP7A1 gene expression. However, following knockdown of FGF19, CDCA still independently decreased BA synthesis, presumably through the regulatory protein small heterodimer partner (SHP). In summary, we show that in primary human hepatocytes CDCA regulates BA synthesis in an FGF19-independent manner.

Fibroblast growth factor 7 inhibits cholesterol 7α-hydroxylase gene expression in hepatocytes

2012 ◽  
Vol 423 (4) ◽  
pp. 775-780 ◽  
Author(s):  
Zhichao Sun ◽  
Xuemei Yu ◽  
Weibin Wu ◽  
Dongwei Jia ◽  
Yinle Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Hydroxylase Gene
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