scholarly journals RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma

Hepatology ◽  
2008 ◽  
Vol 48 (4) ◽  
pp. 1118-1127 ◽  
Author(s):  
Yung-Ming Jeng ◽  
Cheng-Chi Chang ◽  
Fu-Chang Hu ◽  
Han-Yi E. Chou ◽  
Hsin-Lien Kao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Invasion ◽  
Poor Prognosis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Early Recurrence ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals Dwarfism and Impaired Gut Development in Insulin-Like Growth Factor II mRNA-Binding Protein 1-Deficient Mice

2004 ◽  
Vol 24 (10) ◽  
pp. 4448-4464 ◽  
Author(s):  
Thomas V. O. Hansen ◽  
Niels A. Hammer ◽  
Jacob Nielsen ◽  
Mette Madsen ◽  
Charlotte Dalbaeck ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Rna Binding ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Extracellular Matrix Components ◽  
Mrna Binding Protein ◽  
Mrna Binding ◽  
Deficient Mice

ABSTRACT Insulin-like growth factor II mRNA-binding protein 1 (IMP1) belongs to a family of RNA-binding proteins implicated in mRNA localization, turnover, and translational control. Mouse IMP1 is expressed during early development, and an increase in expression occurs around embryonic day 12.5 (E12.5). To characterize the physiological role of IMP1, we generated IMP1-deficient mice carrying a gene trap insertion in the Imp1 gene. Imp1−/− mice were on average 40% smaller than wild-type and heterozygous sex-matched littermates. Growth retardation was apparent from E17.5 and remained permanent into adult life. Moreover, Imp1−/− mice exhibited high perinatal mortality, and only 50% were alive 3 days after birth. In contrast to most other organs, intestinal epithelial cells continue to express IMP1 postnatally, and Imp1−/− mice exhibited impaired development of the intestine, with small and misshapen villi and twisted colon crypts. Analysis of target mRNAs and global expression profiling at E12.5 indicated that Igf2 translation was downregulated, whereas the postnatal intestine showed reduced expression of transcripts encoding extracellular matrix components, such as galectin- 1, lumican, tenascin-C, procollagen transcripts, and the Hsp47 procollagen chaperone. Taken together, the results demonstrate that IMP1 is essential for normal growth and development. Moreover, IMP1 may facilitate intestinal morphogenesis via regulation of extracellular matrix formation.

Abstract 3100: The RNA-binding protein insulin-like growth factor 2 mRNA-binding protein 3 is oncogenic in liposarcoma

2010 ◽  
Author(s):  
Christina V. Angeles ◽  
Markus Hafner ◽  
Nicholas D. Socci ◽  
Penelope DeCarolis ◽  
Thomas Tuschl ◽  
...  
Keyword(s):  
Growth Factor ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Insulin Like Growth Factor ◽  
Mrna Binding Protein ◽  
Mrna Binding

scholarly journals A repeated IMP-binding motif controls oskar mRNA translation and anchoring independently of Drosophila melanogaster IMP

2006 ◽  
Vol 172 (4) ◽  
pp. 577-588 ◽  
Author(s):  
Trent P. Munro ◽  
Sunjong Kwon ◽  
Bruce J. Schnapp ◽  
Daniel St Johnston
Keyword(s):  
Drosophila Melanogaster ◽  
Rna Binding ◽  
Binding Protein ◽  
Mrna Translation ◽  
Binding Motif ◽  
Insulin Growth Factor ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Exponential Enrichment ◽  
Mrna Binding

Zip code–binding protein 1 (ZBP-1) and its Xenopus laevis homologue, Vg1 RNA and endoplasmic reticulum–associated protein (VERA)/Vg1 RNA-binding protein (RBP), bind repeated motifs in the 3′ untranslated regions (UTRs) of localized mRNAs. Although these motifs are required for RNA localization, the necessity of ZBP-1/VERA remains unresolved. We address the role of ZBP-1/VERA through analysis of the Drosophila melanogaster homologue insulin growth factor II mRNA–binding protein (IMP). Using systematic evolution of ligands by exponential enrichment, we identified the IMP-binding element (IBE) UUUAY, a motif that occurs 13 times in the oskar 3′UTR. IMP colocalizes with oskar mRNA at the oocyte posterior, and this depends on the IBEs. Furthermore, mutation of all, or subsets of, the IBEs prevents oskar mRNA translation and anchoring at the posterior. However, oocytes lacking IMP localize and translate oskar mRNA normally, illustrating that one cannot necessarily infer the function of an RBP from mutations in its binding sites. Thus, the translational activation of oskar mRNA must depend on the binding of another factor to the IBEs, and IMP may serve a different purpose, such as masking IBEs in RNAs where they occur by chance. Our findings establish a parallel requirement for IBEs in the regulation of localized maternal mRNAs in D. melanogaster and X. laevis.

scholarly journals Insulin-like growth factor-II mRNA-binding protein 3 predicts a poor prognosis for colorectal adenocarcinoma

2013 ◽  
Vol 6 (3) ◽  
pp. 740-744 ◽  
Author(s):  
LIJUAN LIN ◽  
JINHUI ZHANG ◽  
YAN WANG ◽  
WEIEI JU ◽  
YIBING MA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Poor Prognosis ◽  
Colorectal Adenocarcinoma ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Ii ◽  
Mrna Binding Protein ◽  
Mrna Binding
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