scholarly journals Rapid virological response to peginterferon and ribavirin for hepatitis C genotype 1: The role of weight-based ribavirin exposure

Hepatology ◽  
2008 ◽  
Vol 48 (3) ◽  
pp. 1019-1020 ◽  
Author(s):  
Ming-Lung Yu ◽  
Chia-Yen Dai ◽  
Jee-Fu Huang ◽  
Wan-Long Chuang
Keyword(s):  
Hepatitis C ◽  
Virological Response ◽  
Rapid Virological Response ◽  
Genotype 1 ◽  
Peginterferon And Ribavirin

scholarly journals Rapid virological response and treatment duration for chronic hepatitis C genotype 1 patients: A randomized trial

Hepatology ◽  
2008 ◽  
Vol 47 (6) ◽  
pp. 1884-1893 ◽  
Author(s):  
Ming-Lung Yu ◽  
Chia-Yen Dai ◽  
Jee-Fu Huang ◽  
Chang-Fu Chiu ◽  
Yi-Hsin C. Yang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Randomized Trial ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Treatment Duration ◽  
Rapid Virological Response ◽  
Genotype 1

Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C

2012 ◽  
Vol 17 (5) ◽  
pp. 823-831 ◽  
Author(s):  
Salvatore Petta ◽  
Donatella Ferraro ◽  
Calogero Cammà ◽  
Daniela Cabibi ◽  
Antonietta Di Cristina ◽  
...  
Keyword(s):  
Vitamin D ◽  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Virological Response ◽  
Standard Of Care ◽  
Rapid Virological Response ◽  
Genotype 1 ◽  
Vitamin D Levels

scholarly journals Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients

2018 ◽  
Vol 12 (09) ◽  
pp. 762-770
Author(s):  
Mosin S Khan ◽  
Abid Shoukat ◽  
Syed Mudassar ◽  
Zaffar Kawoosa ◽  
Altaf H Shah ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Hepatitis C ◽  
Virological Response ◽  
Rapid Virological Response ◽  
Viral Genotype ◽  
Genotype 1 ◽  
Genotype 3 ◽  
Significant Difference ◽  
History Of ◽  
End Stage

Introduction: Viral genotype and variation in host genes involved in the immune response may predict the treatment response in patients infected with HCV. The present study was designed to determine the distribution pattern of HCV and host genotypes in Chronic Hepatitis C (CHC) patients and their association with virological response and other risk factors. Methodology: Two hundred and fifty (n = 250) HCV positive patients were included in the study. HCV and Interleukin 28B (IL28B) genotyping was carried out by PCR-RFLP. Results: Viral genotype 3 was the predominant genotype seen in 187 (74.8%) patients. Wild genotype predominated in rs12979860, rs12980275 and rs8099917 SNP of IL28B gene. A significant difference was found in end stage virological response (EVR) between HCV genotype 1 infected patients with wild and variant genotype for rs12980275 and rs8099917 SNPs respectively (P < 0.05). On multivariate analysis all the SNPs were found to be associated with each other (P < 0.05) with rs12980275 SNP associated with history of Jaundice (P < 0.05). Viral genotype 3 was significantly associated with age (< 50 years) and rapid virological response (RVR) while as viral genotype 1 was significantly associated with history of surgery on multivariate analysis (P < 0.05). Conclusions: The viral genotype and IL28B polymorphisms are important factors to personalize antiviral therapy of patients with CHC.

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