scholarly journals Epithelial expression of angiogenic growth factors modulate arterial vasculogenesis in human liver development

Hepatology ◽  
2007 ◽  
Vol 47 (2) ◽  
pp. 719-728 ◽  
Author(s):  
Luca Fabris ◽  
Massimiliano Cadamuro ◽  
Louis Libbrecht ◽  
Peggy Raynaud ◽  
Carlo Spirlì ◽  
...  
Keyword(s):  
Growth Factors ◽  
Human Liver ◽  
Liver Development ◽  
Angiogenic Growth Factors

Angiogenesis: molecular mechanisms and functional interactions

2003 ◽  
Vol 89 (01) ◽  
pp. 190-197 ◽  
Author(s):  
Georg Breier ◽  
Hellmut Augustin
Keyword(s):  
Growth Factors ◽  
Research Program ◽  
Tumor Invasion ◽  
Molecular Mechanisms ◽  
Precursor Cells ◽  
Invasion And Metastasis ◽  
Angiogenic Growth Factors ◽  
Cell Contacts ◽  
Functional Interactions ◽  
Biannual Meeting

SummaryThe German Priority Research Program “Angiogenesis” (www.angiogenese.de) hosts a biannual meeting in the Kloster Seeon in Southern Germany. The 2nd Kloster Seeon Meeting “Angiogenesis: Molecular Mechanisms and Functional Interactions” was held in September 2002. It included sessions on hypoxia, the biology of endothelial precursor cells, angiogenic growth factors including VEGFs, the angiopoietins, ephrins, and FGFs, mechanisms of vascular sprouting and cell-cell contacts during angiogenesis, angiogenic signaling, lymphangiogenesis, angiogenesis during tumor invasion and metastasis, and on novel angiomanipulatory therapies. This report summarizes the key findings reported during the platform presentations of the meeting.

Matrix metalloproteinases in early human liver development

1999 ◽  
Vol 112 (4) ◽  
pp. 277-282 ◽  
Author(s):  
F. Quondamatteo ◽  
T. Knittel ◽  
M. Mehde ◽  
G. Ramadori ◽  
R. Herken
Keyword(s):  
Matrix Metalloproteinases ◽  
Human Liver ◽  
Liver Development ◽  
Early Human

scholarly journals Neurotrophin-3 accelerates reendothelialization through inducing EPC mobilization and homing

2020 ◽  
Vol 15 (1) ◽  
pp. 241-250
Author(s):  
Yan Chen ◽  
Jian Cao ◽  
Weixia Peng ◽  
Wen Chen
Keyword(s):  
Growth Factors ◽  
Carotid Artery ◽  
Animal Experiments ◽  
Flow Chamber ◽  
Control Group ◽  
Angiogenic Growth Factors ◽  
Neurotrophin 3 ◽  
Stromal Cell Derived Factor ◽  
Intravascular Stent ◽  
Endothelial Growth Factor

AbstractRapid endothelialization is an effective way to treat intimal hyperplasia after intravascular stent implantation. Blood vessels and nerves coordinate with each other in function, while neurotrophin-3 (NT-3) is an important class of nerve growth factors. Our study found that NT-3 promoted endothelial progenitor cell (EPC) mobilization, and the proportion of EPCs in peripheral blood was increased by 1.774 times compared with the control group. Besides, NT-3 promoted the expression of stromal cell-derived factor-1α (SDF-1α), matrix metalloproteinase-9 (MMP9), and chemokine (C-X-C motif) receptor 4 (CXCR4) in EPCs, which increased by 59.89%, 74.46%, and 107.7%, respectively, compared with the control group. Transwell experiments showed that NT-3 enhanced the migration of EPCs by 1.31 times. Flow chamber experiments demonstrated that NT-3 captured more circulating EPCs. As shown by ELISA results, NT-3 can promote the paracrine of vascular endothelial growth factor, interleukin-8, MMP-9, and SDF-1 from EPCs. Such increased angiogenic growth factors further accelerated the closure of endothelial cell scratches. Additionally, EPC-conditioned medium in the NT-3 group significantly inhibited the proliferation of vascular smooth muscle cells. Then animal experiments also illustrated that NT-3 prominently accelerated the endothelialization of injured carotid artery. In short, NT-3 accelerated rapid reendothelialization of injured carotid artery through promoting EPC mobilization and homing.

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