T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells

Hepatology ◽  
2006 ◽  
Vol 44 (5) ◽  
pp. 1182-1190 ◽  
Author(s):  
Alessandra Warren ◽  
David G. Le Couteur ◽  
Robin Fraser ◽  
David G. Bowen ◽  
Geoffrey W. McCaughan ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
T Lymphocytes ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Murine Liver

scholarly journals Chemokine Transfer by Liver Sinusoidal Endothelial Cells Contributes to the Recruitment of CD4+ T Cells into the Murine Liver

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0123867 ◽  
Author(s):  
Katrin Neumann ◽  
Ulrike Erben ◽  
Nils Kruse ◽  
Katja Wechsung ◽  
Michael Schumann ◽  
...  
Keyword(s):  
T Cells ◽  
Endothelial Cells ◽  
Cd4 T Cells ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Murine Liver

scholarly journals Expression of Factor VIII by Murine Liver Sinusoidal Endothelial Cells

1999 ◽  
Vol 274 (28) ◽  
pp. 19587-19592 ◽  
Author(s):  
Hung Do ◽  
John F. Healey ◽  
Edmund K. Waller ◽  
Pete Lollar
Keyword(s):  
Endothelial Cells ◽  
Factor Viii ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Murine Liver

scholarly journals The mannose receptor on murine liver sinusoidal endothelial cells is the main denatured collagen clearance receptor

Hepatology ◽  
2007 ◽  
Vol 45 (6) ◽  
pp. 1454-1461 ◽  
Author(s):  
Ivana Malovic ◽  
Karen K. Sørensen ◽  
Kjetil H. Elvevold ◽  
Geir Ivar Nedredal ◽  
Steinar Paulsen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mannose Receptor ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Murine Liver ◽  
Clearance Receptor

Toll-like receptor 9 (TLR9) is present in murine liver sinusoidal endothelial cells (LSECs) and mediates the effect of CpG-oligonucleotides

2006 ◽  
Vol 44 (5) ◽  
pp. 939-946 ◽  
Author(s):  
Montserrat Martin-Armas ◽  
Jaione Simon-Santamaria ◽  
Ingvild Pettersen ◽  
Ugo Moens ◽  
Bård Smedsrød ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Toll Like Receptor ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Cpg Oligonucleotides ◽  
Murine Liver

Crosstalk between Murine Liver Sinusoidal Endothelial Cells (LSEC) and Hematopoietic Stem Cells during In Vitro Hematopoiesis.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4245-4245
Author(s):  
Jose E. Cardier ◽  
Gonzalo Luna
Keyword(s):  
Stem Cells ◽  
Endothelial Cells ◽  
Hematopoietic Stem Cells ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Hematopoietic Stem ◽  
Gm Csf ◽  
Hematopoietic Microenvironment ◽  
Murine Liver

Abstract Crosstalk between murine liver sinusoidal endothelial cells (LSEC) and hematopoietic stem cells during in vitro hematopoiesis. G. Luna, J. E. Cardier. Laboratorio de Patologia Celular y Molecular, Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas (IVIC). Apartado 21827, Caracas, Venezuela We have showed that at the liver there is a specific hematopoietic microenvironment, constituted by the liver sinusoid endothelial cells (LSEC), which are capable to support, in vitro and in vivo, not only the proliferation but also the differentiation and survival of hematopoietic stem cells (HSC). The ability of LSEC to support hematopoiesis could be related to specific hematopoietic molecules expressed by these cells. In this study, we investigate the expression of some cell adhesion molecules (VCAM-1, ICAM-1, and the integrin a4b1 ), and early acting hematopoietic cytokines (IL-6 and GM-CSF), on LSEC cocultured with HSC. The expression of VCAM-1, ICAM-1, α4β1, IL6 and GM-SCF was increased on LSEC cocultured with HSC. In contrast, a significant decrease in the expression of IL-6 and GM-CSF in the HSC derived from the same cocultures was observed. The blockade of VCAM-1 on LSEC reduced significantly the adhesion of HSC to LSEC monolayers, suggesting that this molecule is involved in the binding of HSC to LSEC microenvironments. There were not changes in the expression of the molecules evaluated when the LSEC and HSC were co-cultured in non-contact conditions, suggesting that soluble factors do not participate in regulating the expression of these molecules. Our data shows that during in vitro hematopoiesis, LSEC are activated to express molecules associated with the hematopoiesis process. LSEC activation is regulated by the contact between these cells and HSC. By expressing critical hematopoietic microenvironment molecules, LSEC may regulate the proliferation and differentiation of HSC, during liver extramedullary hematopoiesis.

Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells

2013 ◽  
Vol 58 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Antonella Carambia ◽  
Christian Frenzel ◽  
Oliver T. Bruns ◽  
Dorothee Schwinge ◽  
Rudolph Reimer ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
T Cell ◽  
Cell Activity ◽  
Cd4 T Cell ◽  
Liver Sinusoidal Endothelial Cells ◽  
Sinusoidal Endothelial Cells ◽  
Murine Liver
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