Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease

Hepatology ◽  
2006 ◽  
Vol 44 (4) ◽  
pp. 874-880 ◽  
Author(s):  
Raphael B. Merriman ◽  
Linda D. Ferrell ◽  
Marco G. Patti ◽  
Shiobhan R. Weston ◽  
Mark S. Pabst ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Nonalcoholic Fatty Liver ◽  
Liver Biopsies

scholarly journals Hepatic chemerin mRNA in morbidly obese patients with nonalcoholic fatty liver disease

2017 ◽  
Vol 2 ◽  
pp. 117-127 ◽  
Author(s):  
Maciej Kajor ◽  
Michał Kukla ◽  
Marek Waluga ◽  
Łukasz Liszka ◽  
Michał Dyaczyński ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Nonalcoholic Fatty Liver

scholarly journals Hepatic Gene Networks in Morbidly Obese Patients With Nonalcoholic Fatty Liver Disease

2010 ◽  
Vol 20 (12) ◽  
pp. 1698-1709 ◽  
Author(s):  
Samer Gawrieh ◽  
Tesfaye M. Baye ◽  
Melanie Carless ◽  
James Wallace ◽  
Richard Komorowski ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Gene Networks ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Nonalcoholic Fatty Liver

scholarly journals Performance of Noninvasive Liver Fibrosis Tests in Morbidly Obese Patients with Nonalcoholic Fatty Liver Disease

2021 ◽  
Author(s):  
Saleh A. Alqahtani ◽  
Pegah Golabi ◽  
James M. Paik ◽  
Brian Lam ◽  
Amir H. Moazez ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Advanced Fibrosis ◽  
Predictive Values ◽  
Nonalcoholic Fatty Liver ◽  
Optimal Thresholds

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in morbidly obese patients, and fibrosis is an independent predictor of mortality. Noninvasive tests (NITs) are being developed for the detection of advanced fibrosis (AF). Purpose To assess the performance of three NITs (NAFLD fibrosis score, NFS, fibrosis-4 index, FIB-4, and aspartate aminotransferase-to-platelet ratio, APRI), in the identification of AF among morbidly obese patients. Materials and Methods Patients, who underwent bariatric surgery between 2004 and 2009 and had liver biopsy, were included. Fibrosis stages ≥ F2 and ≥ F3 were defined as significant and AF, respectively. Published and optimal thresholds (Youden index) for NFS, FIB-4 and APRI, sensitivity, specificity, positive and negative predictive values (PPV-NPV), and area under the receiver operator curves (AUROC) were evaluated. Results Among 584 patients (mean age 43.3 ± 11.3 years, 21.2% male, 75% white, mean BMI 45.5 ± 8.80), 31.7% had NASH. Stages distributions were F1 = 68.1%, F2 = 16.4%, F3 = 8%, and F4 = 3.2%. At published thresholds, all 3 NITs performed poorly for detection of AF, with AUROC < 0.62. Overall performance at optimal thresholds improved to 0.68, 0.72, and 0.74 for NFS, FIB-4, and APRI, respectively. At optimal thresholds, all tests had good NPV (94.4–95.9%) but low PPV (24.2–32.5%). Combinations of the tests did not improve their performance. Conclusions NFS, FIB-4, and APRI fall short to detect advanced fibrosis but valuable for excluding advanced fibrosis. More research is needed to develop new NITs with high positive predictive value.

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