Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis

Hepatology ◽  
2005 ◽  
Vol 42 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Daryl T.-Y. Lau ◽  
Bruce A. Luxon ◽  
Shu-Yuan Xiao ◽  
Michael R. Beard ◽  
Stanley M. Lemon
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Expression Profiles ◽  
Smooth Muscle Actin ◽  
Gene Expression Profiles ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin

The hepatitis C virus core protein indirectly induces alpha-smooth muscle actin expression in hepatic stellate cells via interleukin-8

2010 ◽  
Vol 52 (5) ◽  
pp. 635-643 ◽  
Author(s):  
Sophie Clément ◽  
Stéphanie Pascarella ◽  
Stéphanie Conzelmann ◽  
Carmen Gonelle-Gispert ◽  
Kévin Guilloux ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Hepatitis C ◽  
Hepatic Stellate Cells ◽  
Core Protein ◽  
Smooth Muscle Actin ◽  
Stellate Cells ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Virus Core ◽  
Actin Expression

scholarly journals Differentially regulated gene expression associated with hepatitis C virus clearance

2013 ◽  
Vol 94 (3) ◽  
pp. 534-542 ◽  
Author(s):  
Carolyn Z. Grimes ◽  
Lu-Yu Hwang ◽  
Peng Wei ◽  
Dimpy P. Shah ◽  
Kelly A. Volcik ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Drug Users ◽  
Expression Profiles ◽  
Treatment Strategies ◽  
Gene Expression Profiles ◽  
Spontaneous Resolution ◽  
Virus Clearance ◽  
Regulated Gene Expression

Human chronic hepatitis C virus (HCV) infections pose a significant public health threat, necessitating the development of novel treatments and vaccines. HCV infections range from spontaneous resolution to end-stage liver disease. Approximately 10–30 % of HCV infections undergo spontaneous resolution independent of treatment by yet-to-be-defined mechanisms. These individuals test positive for anti-HCV antibodies in the absence of detectable viral serum RNA. To identify genes associated with HCV clearance, this study compared gene expression profiles between current drug users chronically infected with HCV and drug users who cleared their HCV infection. This analysis identified 91 differentially regulated (up- or downregulated by twofold or more) genes potentially associated with HCV clearance. The majority of genes identified were associated with immune function, with the remaining genes categorized either as cancer related or ‘other’. Identification of factors and pathways that may influence virus clearance will be essential to the development of novel treatment strategies.

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