scholarly journals Molecular analysis of HLA class II associations with hepatitis B virus clearance and vaccine nonresponsiveness

Hepatology ◽  
2005 ◽  
Vol 41 (6) ◽  
pp. 1383-1390 ◽  
Author(s):  
Andrew Godkin ◽  
Miles Davenport ◽  
Adrian V.S. Hill
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Analysis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Virus Clearance ◽  
B Virus

scholarly journals In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana

Viruses ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 731 ◽  
Author(s):  
Wonderful Tatenda Choga ◽  
Motswedi Anderson ◽  
Edward Zumbika ◽  
Bonolo B. Phinius ◽  
Tshepiso Mbangiwa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
In Silico ◽  
Class Ii ◽  
Hla Class Ii ◽  
Hbv Infection ◽  
Diagnostic Kits ◽  
Immunological Responses ◽  
B Virus ◽  
Epitope Vaccines

Hepatitis B virus (HBV) is the primary cause of liver-related malignancies worldwide, and there is no effective cure for chronic HBV infection (CHB) currently. Strong immunological responses induced by T cells are associated with HBV clearance during acute infection; however, the repertoire of epitopes (epi) presented by major histocompatibility complexes (MHCs) to elicit these responses in various African populations is not well understood. In silico approaches were used to map and investigate 15-mers HBV peptides restricted to 9 HLA class II alleles with high population coverage in Botswana. Sequences from 44 HBV genotype A and 48 genotype D surface genes (PreS/S) from Botswana were used. Of the 1819 epi bindings predicted, 20.2% were strong binders (SB), and none of the putative epi bind to all the 9 alleles suggesting that multi-epitope, genotype-based, population-based vaccines will be more effective against HBV infections as opposed to previously proposed broad potency epitope-vaccines which were assumed to work for all alleles. In total, there were 297 unique epi predicted from the 3 proteins and amongst, S regions had the highest number of epi (n = 186). Epitope-densities (Depi) between genotypes A and D were similar. A number of mutations that hindered HLA-peptide binding were observed. We also identified antigenic and genotype-specific peptides with characteristics that are well suited for the development of sensitive diagnostic kits. This study identified candidate peptides that can be used for developing multi-epitope vaccines and highly sensitive diagnostic kits against HBV infection in an African population. Our results suggest that viral variability may hinder HBV peptide-MHC binding, required to initiate a cascade of immunological responses against infection.

Heterozygote advantage for HLA class-II type in hepatitis B virus infection

1997 ◽  
Vol 17 (1) ◽  
pp. 11-12 ◽  
Author(s):  
Mark R. Thursz ◽  
Howard C. Thomas ◽  
Brian M. Greenwood ◽  
Adrian V.S. Hill
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Class Ii ◽  
Hla Class Ii ◽  
Heterozygote Advantage ◽  
Hepatitis B Virus Infection ◽  
B Virus

scholarly journals Hepatitis B virus clearance rate estimates

Hepatology ◽  
2009 ◽  
Vol 49 (5) ◽  
pp. 1779-1780 ◽  
Author(s):  
Harel Dahari ◽  
Scott J. Cotler ◽  
Thomas J. Layden ◽  
Alan S. Perelson
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Clearance Rate ◽  
Virus Clearance ◽  
B Virus

Epidemiological and molecular analysis of hepatitis B virus infection in manicurists in Central Brazil

2017 ◽  
Vol 90 (2) ◽  
pp. 277-281
Author(s):  
Larissa Cavaretto ◽  
Ana R.C. Motta-Castro ◽  
Sheila A. Teles ◽  
Fernanda Q. Souza ◽  
Wesley M. Cardoso ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Molecular Analysis ◽  
Hepatitis B Virus Infection ◽  
Central Brazil ◽  
B Virus

scholarly journals Selecting a Genetic Region for Molecular Analysis of Hepatitis B Virus Transmission

2007 ◽  
Vol 45 (2) ◽  
pp. 687-689 ◽  
Author(s):  
S. Datta ◽  
A. Banerjee ◽  
P. K. Chandra ◽  
R. Chakravarty ◽  
B. C. Cowie
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Molecular Analysis ◽  
Virus Transmission ◽  
Genetic Region ◽  
B Virus
Sign in / Sign up

Export Citation Format

Share Document