Patient and graft survival after liver transplantation for hereditary hemochromatosis: Implications for pathogenesis

Hepatology ◽  
2004 ◽  
Vol 39 (6) ◽  
pp. 1655-1662 ◽  
Author(s):  
Darrell H.G. Crawford ◽  
Linda M. Fletcher ◽  
Stefan G. Hubscher ◽  
Katherine A. Stuart ◽  
Edward Gane ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Hereditary Hemochromatosis ◽  
Patient And Graft Survival

Both Alcoholic and Nonalcoholic Steatohepatitis Is an Emerging Indication for Liver Transplantation in the United States

2020 ◽  
Vol 04 (02) ◽  
pp. 223-234
Author(s):  
Danielle Fritze ◽  
Amandeep Singh ◽  
Eric Lawitz ◽  
Kris V. Kowdley ◽  
Glenn Halff ◽  
...  
Keyword(s):  
United States ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Nonalcoholic Steatohepatitis ◽  
Multivariable Analysis ◽  
Deceased Donor ◽  
The United States ◽  
Hispanic Males ◽  
Patient And Graft Survival ◽  
United Network

Abstract Background Nonalcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) are now the most common indications for liver transplantation (LT) in the United States. A subset of patients have both alcoholic and nonalcoholic steatohepatitis (BASH). This study characterizes patients with BASH requiring LT and assesses changes in the prevalence of BASH as an indication for LT. Methods The United Network for Organ Sharing database was analyzed for all patients ≥ 18 years of age who received their first deceased donor LT from 2002 to 2016 for ALD, NASH, or BASH. Baseline demographics, clinical parameters, and LT outcomes were compared between groups. Results Since 2002, 85,448 patients underwent LT:15,327 had ALD, 9,971 had NASH, and 2,779 had BASH. The prevalence of BASH as an indication for LT increased from 0.5% in 2002 to 5% in 2016. Compared with patients with NASH, those with BASH were significantly more likely to be male (85.6 vs. 57%), younger (mean 56.4 vs. 58.6 years), and Hispanic (22.2 vs. 13.6%) (p < 0.001 for all). While indication for transplant was not significantly associated with transplant outcomes on multivariable analysis, patient and graft survival curves do differ significantly by indication for transplant, with worse outcomes for patients with BASH (patient survival at 5 years: NASH 78.1%, ALD 77.2%, BASH 73.5%, p = 0.013; graft survival at 5 years: NASH 75.3%, ALD 74.0%, BASH 70.8%, p = 0.046). Conclusions BASH is a rising indication for LT, especially for Hispanic males, due to the increasing prevalence of ALD and NASH in the United States.

Anti-IL2 Induction in Liver Transplantation with 93% Rejection-Free Patient and Graft Survival at 18 Months

2007 ◽  
Vol 138 (2) ◽  
pp. 198-204 ◽  
Author(s):  
Carlo B. Ramirez ◽  
Cataldo Doria ◽  
Fabrizio di Francesco ◽  
Maurizio Iaria ◽  
Yoogoo Kang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Patient And Graft Survival

MELD score can predict post-orthotopic liver transplantation one-year patient and graft survival

2003 ◽  
Vol 124 (4) ◽  
pp. A694
Author(s):  
Sammy Saab ◽  
Victor S. Wang ◽  
Ayman B. Ibrahim ◽  
Francisco Durazo ◽  
Steven Han ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Orthotopic Liver Transplantation ◽  
Meld Score ◽  
One Year ◽  
Patient And Graft Survival

THE IMPACT OF DONOR AGE ON LIVER TRANSPLANTATION: INFLUENCE OF DONOR AGE ON EARLY LIVER FUNCTION AND ON SUBSEQUENT PATIENT AND GRAFT SURVIVAL

2001 ◽  
Vol 71 (12) ◽  
pp. 1765-1771 ◽  
Author(s):  
Juli Busquets ◽  
Xavier Xiol ◽  
Juan Figueras ◽  
Eduardo Jaurrieta ◽  
Jaume Torras ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Graft Survival ◽  
Donor Age ◽  
The Impact ◽  
Subsequent Patient ◽  
Patient And Graft Survival

scholarly journals Type of Preservation Solution, UW or HTK, Has an Impact on the Incidence of Biliary Stricture following Liver Transplantation: A Retrospective Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Rojbin Karakoyun ◽  
Antonio Romano ◽  
Johan Nordström ◽  
Bo-Göran Ericzon ◽  
Greg Nowak
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Biliary Stricture ◽  
Solid Organ Transplantation ◽  
Vascular Complications ◽  
Blood Chemistry ◽  
Liver Graft ◽  
Solid Organ ◽  
Preservation Solution ◽  
Patient And Graft Survival

Organ preservation plays a crucial role in the outcome following solid organ transplantation. The aim of this study was to perform a retrospective outcome analysis following liver transplantation using histidine tryptophan ketoglutarate (HTK) or the University of Wisconsin (UW) solutions for liver graft preservation. We retrospectively reviewed data on adult patients who were liver-transplanted at Karolinska University Hospital between 2007 and 2015. There was evaluation of donor and recipient characteristics, pre- and post-transplant blood chemistry tests, biliary and vascular complications, graft dysfunction and nonfunction, and patient and graft survivals. A total of 433 patients were included in the analyses, with 230 and 203 patients having received livers preserved with HTK and UW, respectively. Mean follow-up was 45 ± 29 months for the HTK group and 42.4 ± 26 for the UW group. There was no difference between the two groups either in terms of patient and graft survival, or of results of postoperative blood chemistry, or incidence of arterial complications, early allograft dysfunction, or primary graft nonfunction. However, the incidence of biliary stricture was higher in the UW group (22.7%) versus the HTK group (13.5%; p=0.013). Use of UW and HTK preservation solution in liver transplantation has no impact on patient and graft survival. However, use of HTK solution results in a lower incidence of posttransplant biliary stricture.

Long-term patient and graft survival after liver transplantation for autoimmune hepatitis

2020 ◽  
Vol 73 ◽  
pp. S21-S22
Author(s):  
Melina Heinemann ◽  
René Adam ◽  
Marina Berenguer Haym ◽  
Darius F. Mirza ◽  
Seyed Ali Malek-Hosseini ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Autoimmune Hepatitis ◽  
Graft Survival ◽  
Patient And Graft Survival
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