scholarly journals Introduction of a murine p53 mutation corresponding to human codon 249 into a murine hepatocyte cell line results in growth advantage, but not in transformation

Hepatology ◽  
1995 ◽  
Vol 22 (4) ◽  
pp. 1279-1288 ◽  
Author(s):  
Luba Dumenco ◽  
Delphine Oguey ◽  
Justina Wu ◽  
Norma Messier ◽  
Nelson Fausto
Keyword(s):  
Cell Line ◽  
P53 Mutation ◽  
Hepatocyte Cell Line ◽  
Murine Hepatocyte

scholarly journals Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line

2012 ◽  
Vol 83 (2) ◽  
pp. 269-278 ◽  
Author(s):  
Cécile Ménez ◽  
Laïla Mselli-Lakhal ◽  
Magali Foucaud-Vignault ◽  
Patrick Balaguer ◽  
Michel Alvinerie ◽  
...  
Keyword(s):  
Cell Line ◽  
Mrna Stabilization ◽  
Hepatocyte Cell Line ◽  
P Glycoprotein ◽  
And Function ◽  
Murine Hepatocyte

Enhancement of survival by LPA via Erk1/Erk2 and PI 3-kinase/Akt pathways in a murine hepatocyte cell line

2001 ◽  
Vol 281 (6) ◽  
pp. C2010-C2019 ◽  
Author(s):  
Yuri Y. Sautin ◽  
James M. Crawford ◽  
Stanislav I. Svetlov
Keyword(s):  
Cell Line ◽  
Mitogen Activated Protein Kinase ◽  
Dependent Manner ◽  
Protective Effects ◽  
Hepatocellular Injury ◽  
Cell Protection ◽  
Lpa Receptor ◽  
Hepatocyte Cell Line ◽  
Tnf Α ◽  
Murine Hepatocyte

First published September 5, 2001; 10.1152/ajpcell.00077.2001.—Protective mechanisms for lysophosphatidic acid (LPA) against cell death caused by Clostridium difficile toxin, or tumor necrosis factor-α (TNF-α) plus d-galactosamine, were investigated in a murine hepatocyte cell line AML12 expressing Edg2 LPA receptor. In these models of hepatocellular injury, LPA prevented hepatocyte damage, suppressed apoptosis, and enhanced cell survival in a dose-dependent fashion. The protective effects of LPA were abolished by wortmannin and LY-294002, specific inhibitors of phosphatidylinositol 3-phosphate kinase (PI 3-kinase), and by PD-98059 and U-0126, inhibitors of MEK1/MEK2. In nontreated hepatocytes, LPA elicited a gradual and sustained increase in phosphorylation of Erk1/Erk2 over 180 min of stimulation and downstream phosphorylation of p90RSK and transcription factor Elk-1. In C. difficile toxin-treated cells, LPA-induced phosphorylation of Erk1/Erk2 was rapid but transient, while p90RSK and Elk-1 phosphorylation did not change significantly. LPA stimulated phosphorylation of Akt in a time-dependent manner in both intact and toxin-treated AML12 hepatocytes. Wortmannin and LY-294002 abolished phosphorylation of Akt, further supporting activation of PI 3-kinase/Akt as a signaling pathway, which mediates hepatocyte protection by LPA. Taken together, these results demonstrate that LPA prevents cell apoptosis induced by C. difficile toxin and TNF-α/d-galactosamine in the AML12 murine hepatocyte cell line. Cell protection by LPA involves activation of the mitogen-activated protein kinase Erk1/Erk2 cascade and PI 3-kinase-dependent phosphorylation of Akt.

Thyroid hormone responsive genes in the murine hepatocyte cell line AML 12

Gene ◽  
2007 ◽  
Vol 396 (2) ◽  
pp. 332-337 ◽  
Author(s):  
Tereza Ventura-Holman ◽  
Abulkhair Mamoon ◽  
Joseph F. Maher ◽  
Jose S. Subauste
Keyword(s):  
Thyroid Hormone ◽  
Cell Line ◽  
Hepatocyte Cell Line ◽  
Murine Hepatocyte

Retinoic acid responsive genes in the murine hepatocyte cell line AML 12

Gene ◽  
2008 ◽  
Vol 408 (1-2) ◽  
pp. 95-103 ◽  
Author(s):  
Abulkhair Mamoon ◽  
Tereza Ventura-Holman ◽  
Joseph F. Maher ◽  
Jose S. Subauste
Keyword(s):  
Retinoic Acid ◽  
Cell Line ◽  
Hepatocyte Cell Line ◽  
Murine Hepatocyte
Sign in / Sign up

Export Citation Format

Share Document