Vitamin E dietary supplementation protects against carbon tetrachloride—induced chronic liver damage and cirrhosis

Hepatology ◽  
1992 ◽  
Vol 16 (4) ◽  
pp. 1014-1021 ◽  
Author(s):  
Maurizio Parola ◽  
Gabriella Leonarduzzi ◽  
Fiorella Biasi ◽  
Emanuele Albano ◽  
Maria E. Biocca ◽  
...  
Keyword(s):  
Vitamin E ◽  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Dietary Supplementation ◽  
Chronic Liver ◽  
Chronic Liver Damage

Microcirculatory responses to estradiol benzoate in chronic liver damage induced by carbon tetrachloride in the rat

1984 ◽  
Vol 19 (5) ◽  
pp. 419-423 ◽  
Author(s):  
Kohdoh Ishii ◽  
Sumio Matama ◽  
Hisao Shibata ◽  
Haruya Okabe ◽  
Masahiko Okudaira ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Estradiol Benzoate ◽  
Chronic Liver ◽  
Chronic Liver Damage

scholarly journals Protective effect of dibutyryl adenosine 3',5'-monophosphate on chronic liver damage induced by carbon tetrachloride in the rat.

Kanzo ◽  
1987 ◽  
Vol 28 (6) ◽  
pp. 687-691 ◽  
Author(s):  
Kohdoh ISHII ◽  
Shigenori NII ◽  
Hitomi KARUBE ◽  
Yoshikuni FUJITA ◽  
Hisao SHIBATA ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Liver Damage ◽  
Chronic Liver ◽  
Chronic Liver Damage

scholarly journals Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Erika Ramos-Tovar ◽  
Erika Hernández-Aquino ◽  
Sael Casas-Grajales ◽  
Laura D. Buendia-Montaño ◽  
Silvia Galindo-Gómez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Underlying Mechanism ◽  
Chronic Liver ◽  
Chronic Liver Damage ◽  
Experimental Cirrhosis ◽  
Male Wistar Rats ◽  
First Time

The effect of stevia on liver cirrhosis has not been previously investigated. In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage. Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia. Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations. Subsequently, the underlying mechanism of action of the plant was analyzed. Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition. These multitarget mechanisms led to the prevention of experimental cirrhosis. Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases.

scholarly journals Editorial Expression of Concern: Tumor necrosis factor-inducible gene 6 protein ameliorates chronic liver damage by promoting autophagy formation in mice

2021 ◽  
Author(s):  
Sihyung Wang ◽  
Chanbin Lee ◽  
Jieun Kim ◽  
Jeongeun Hyun ◽  
Minso Lim ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Liver Damage ◽  
Tumor Necrosis ◽  
Chronic Liver ◽  
Chronic Liver Damage ◽  
Necrosis Factor ◽  
Inducible Gene

An Editorial Expression of Concern to this paper has been published: https://doi.org/10.1038/s12276-021-00554-6

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