Human hepatic regenerative stimulator substance: Partial purification and biological characterization of hepatic stimulator substance from human fetal liver cells

Hepatology ◽  
1990 ◽  
Vol 12 (5) ◽  
pp. 1144-1151 ◽  
Author(s):  
Yao Zhiqiang ◽  
Yang Weisong ◽  
Zhang Wenbin ◽  
Chen Yong ◽  
Yang Fengyi
2014 ◽  
Vol 49 (6) ◽  
pp. 705-714 ◽  
Author(s):  
Pradeep B. Patil ◽  
Setara Begum ◽  
Meghnad Joshi ◽  
Marika I Kleman ◽  
Michael Olausson ◽  
...  

2007 ◽  
Vol 30 (11) ◽  
pp. 2091-2097 ◽  
Author(s):  
Masataka Maruyama ◽  
Tamihide Matsunaga ◽  
Eri Harada ◽  
Shigeru Ohmori

2012 ◽  
Vol 27 (6) ◽  
pp. 653-657 ◽  
Author(s):  
Tamihide Matsunaga ◽  
Masataka Maruyama ◽  
Tsutomu Matsubara ◽  
Kiyoshi Nagata ◽  
Yasushi Yamazoe ◽  
...  

Hepatology ◽  
2011 ◽  
Vol 54 (6) ◽  
pp. 1901-1912 ◽  
Author(s):  
Linda Andrus ◽  
Svetlana Marukian ◽  
Christopher T. Jones ◽  
Maria Teresa Catanese ◽  
Timothy P. Sheahan ◽  
...  

1977 ◽  
Vol 55 (5) ◽  
pp. 571-575 ◽  
Author(s):  
L. F. Congote ◽  
F. Bruno ◽  
S. Solomon

α-Fetoprotein and the synthesis of heme associated with hemoglobin were measured simultaneously in short-term cultures of human fetal liver cells to correlate the relationship of α-fetoprotein to erythroid cell function. Both synthetic processes decreased exponentially during the first 5 days of culture. The use of media supplemented with different batches of fetal calf serum and porcine portal vein serum indicated that the optimal conditions for the production of α-fetoprotein were different from those required for the synthesis of heme associated with hemoglobin. Moreover, the α-fetoprotein-producing cells could be separated from erythroid cells after velocity sedimentation in Ficoll gradients. Although it is well known that erythropoiesis and α-fetoprotein production occur simultaneously during ontogenesis, α-fetoprotein itself (0.01–100 μg/ml) did not stimulate heme synthesis in liver erythroid cells. Erythropoietin did not stimulate α-fetoprotein production. It is concluded that there is no cause–effect relationship between α-fetoprotein production and erythroid cell function in human fetal liver cells and that the two processes occur independently in different cell types.


1989 ◽  
Vol 83 (3) ◽  
pp. 1032-1038 ◽  
Author(s):  
T J Ley ◽  
K A Maloney ◽  
J I Gordon ◽  
A L Schwartz

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