Clarifying optimal outcome measures in intermittent and continuous laryngeal neuromonitoring

Head & Neck ◽  
2021 ◽  
Author(s):  
Catherine F. Sinclair ◽  
Erin Buczek ◽  
Elizabeth Cottril ◽  
Peter Angelos ◽  
Marcin Barczynski ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Optimal Outcome

Optimal Outcome Measures for Detecting Clinical Benefits of Early Reperfusion: Insights from the DEFUSE Study

2008 ◽  
Vol 17 (4) ◽  
pp. 235-240 ◽  
Author(s):  
Wataru Kakuda ◽  
Scott Hamilton ◽  
Vincent N. Thijs ◽  
Maarten G. Lansberg ◽  
Stephanie Kemp ◽  
...  
Keyword(s):  
Outcome Measures ◽  
Optimal Outcome ◽  
Early Reperfusion ◽  
Clinical Benefits

Optimal Outcome Measures, Research Priorities, and International Cooperation

2000 ◽  
Vol 21 (Supplement) ◽  
pp. 106S-115S ◽  
Author(s):  
Robyn Cox ◽  
Martyn Hyde ◽  
Stuart Gatehouse ◽  
William Noble ◽  
Harvey Dillon ◽  
...  
Keyword(s):  
International Cooperation ◽  
Outcome Measures ◽  
Research Priorities ◽  
Optimal Outcome

scholarly journals Variation in Outcome Measures in Hip and Knee Arthroplasty Clinical Trials: A Proposed Approach to Achieving Consensus

2009 ◽  
Vol 36 (9) ◽  
pp. 2050-2056 ◽  
Author(s):  
DANIEL L. RIDDLE ◽  
PAUL W. STRATFORD ◽  
JASVINDER A. SINGH ◽  
C. VIBEKE STRAND
Keyword(s):  
Clinical Trials ◽  
Outcome Measures ◽  
Knee Arthroplasty ◽  
Randomized Trials ◽  
Survey Design ◽  
Hip Osteoarthritis ◽  
Optimal Outcome ◽  
The Past ◽  
Hip And Knee Arthroplasty ◽  
Knee And Hip Arthroplasty

OMERACT began work over a decade ago on a consensus effort to identify optimal outcome measures for knee and hip osteoarthritis clinical trials. Recent evidence indicates extensive variation in outcome measures used in clinical trials of knee and hip arthroplasty published since 2000. This heterogeneity leads to confusion, not only for conducting systematic reviews but also for applying evidence to clinical practice. Given the extensive psychometric research conducted in the past 2 decades, the timing seems ideal to design and implement a study to develop consensus on optimal outcome measures for hip and knee arthroplasty trials. We describe a Delphi survey design and an approach for synthesizing the extensive psychometric literature on the outcome measures used in hip and knee arthroplasty trials. Plans for dissemination of the findings are also discussed. This proposed study could have an important influence on the design and reporting of future randomized trials of knee arthroplasty.

scholarly journals Results of a feasibility randomised controlled trial (RCT) for WATCH IT: a programme for obese children and adolescents

2011 ◽  
Vol 8 (6) ◽  
pp. 755-764 ◽  
Author(s):  
Maria Bryant ◽  
Amanda Farrin ◽  
Deborah Christie ◽  
Susan A Jebb ◽  
Ashley R Cooper ◽  
...  
Keyword(s):  
Childhood Obesity ◽  
Sample Size ◽  
Children And Adolescents ◽  
Outcome Measures ◽  
Dropout Rate ◽  
Full Scale ◽  
Phase Iii ◽  
Feasibility Trial ◽  
Future Research ◽  
Optimal Outcome

Background In the evaluation of childhood obesity interventions, few researchers undertake a rigorous feasibility stage in which the design and procedures of the evaluation process are examined. Consequently, phase III studies often demonstrate methodological weaknesses. Purpose Our aim was to conduct a feasibility trial of the evaluation of WATCH IT, a community obesity intervention for children and adolescents. We sought to determine an achievable recruitment rate; acceptability of randomisation, assessment procedures, and dropout rate; optimal outcome measures for the definitive trial; and a robust sample size calculation. Method Our goal was to recruit 70 participants over 6 months, randomise them to intervention or control group, and retain participation for 12 months. Assessments were taken prior to randomisation and after 6 and 12 months. Procedures mirrored those intended for a full-scale trial, but multiple measures of similar outcomes were included as a means to determine those most appropriate for future research. Acceptability of the research and impact of the research on the programme were ascertained through interviewing participants and staff. Results We recruited 70 participants and found that randomisation and data collection procedures were acceptable. Self-referral ( via media promotion) was more effective than professional referral. Blinding of assessors was sustained to a reasonable degree, and optimal outcome measures for a full-scale trial were identified. Estimated sample size was significantly greater than sample sized reported in published trials. There was some negative impact on the existing programme as a result of the research, a lesson for designers of future trials. Limitations We successfully recruited socially disadvantaged families, but the majority of families were of White British nationality. The composition of the participants was an added valuable lesson, suggesting that recruitment strategies to obtain a more heterogeneous ethnic sample warrant consideration in future research. Conclusions This study provided us with confidence that we can run a phase III multi-centre trial to test the effectiveness of WATCH IT. Importantly, it was invaluable in informing the design not only of that trial but also of future evaluations of childhood obesity treatment interventions.

scholarly journals Optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care: a mixed methods consensus process

2020 ◽  
Vol 106 (3) ◽  
pp. 292-297
Author(s):  
Chris Gale ◽  
Jon Dorling ◽  
Barbara Arch ◽  
Kerry Woolfall ◽  
Elizabeth Deja ◽  
...  
Keyword(s):  
Literature Review ◽  
Outcome Measures ◽  
Healthcare Professionals ◽  
Neonatal Care ◽  
Consensus Meeting ◽  
Residual Volume ◽  
Optimal Outcome ◽  
Healthcare Associated Infection ◽  
Gastric Residual Volume ◽  
Routine Measurement

Background Routine measurement of gastric residual volume to guide feeding is widespread in neonatal units but not supported by high-quality evidence. Outcome selection is critical to trial design. Objective To determine optimal outcome measures for a trial of not routinely measuring gastric residual volume in neonatal care. Design A focused literature review, parent interviews, modified two-round Delphi survey and stakeholder consensus meeting. Participants Sixty-one neonatal healthcare professionals participated in an eDelphi survey; 17 parents were interviewed. 19 parents and neonatal healthcare professionals took part in the consensus meeting. Results Literature review generated 14 outcomes, and parent interviews contributed eight additional outcomes; these 22 outcomes were then ranked by 74 healthcare professionals in the first Delphi round where four further outcomes were proposed; 26 outcomes were ranked in the second round by 61 healthcare professionals. Five outcomes were categorised as ‘consensus in’, and no outcomes were voted ‘consensus out’. ‘No consensus’ outcomes were discussed and voted on in a face-to-face meeting by 19 participants, where four were voted ‘consensus in’. The final nine consensus outcomes were: mortality, necrotising enterocolitis, time to full enteral feeds, duration of parenteral nutrition, time feeds stopped per 24 hours, healthcare-associated infection; catheter-associated bloodstream infection, change in weight between birth and neonatal discharge and pneumonia due to milk aspiration. Conclusions and relevance We have identified outcomes for a trial of no routine measurement of gastric residual volume to guide feeding in neonatal care. This outcome set will ensure outcomes are important to healthcare professionals and parents.

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