Hyperintensity of integrin‐targeted fluorescence agent IntegriSense750 accurately predicts flap necrosis compared to Indocyanine green

Head & Neck ◽  
2021 ◽  
Author(s):  
Melanie D. Hicks ◽  
Alyssa K. Ovaitt ◽  
Jason C. Fleming ◽  
Anna G. Sorace ◽  
Patrick N. Song ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Flap Necrosis

How should indocyanine green dye angiography be assessed to best predict mastectomy skin flap necrosis? A systematic review

2020 ◽  
Vol 73 (6) ◽  
pp. 1031-1042 ◽  
Author(s):  
Caroline Driessen ◽  
Tinna Harper Arnardottir ◽  
Andres Rodriguez Lorenzo ◽  
Maria Rydevik Mani
Keyword(s):  
Systematic Review ◽  
Indocyanine Green ◽  
Skin Flap ◽  
Flap Necrosis ◽  
Indocyanine Green Dye ◽  
Skin Flap Necrosis

scholarly journals Evaluation of Intranasal Flap Perfusion by Intraoperative Indocyanine Green Fluorescence Angiography

2018 ◽  
Vol 15 (6) ◽  
pp. 672-676 ◽  
Author(s):  
Mathew Geltzeiler ◽  
Ana Carolina Igami Nakassa ◽  
Meghan Turner ◽  
Pradeep Setty ◽  
George Zenonos ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Skull Base ◽  
Near Infrared ◽  
The Body ◽  
Fluorescence Angiography ◽  
Flap Necrosis ◽  
Endonasal Surgery ◽  
Mri Contrast ◽  
Postoperative Mri ◽  
Flap Perfusion

Abstract BACKGROUND Vascularized intranasal flaps are the primary reconstructive option for endoscopic skull base defects. Flap vascularity may be compromised by injury to the pedicle or prior endonasal surgery. There is currently no validated technique for intraoperative evaluation of intranasal flap viability. OBJECTIVE To evaluate the efficacy of indocyanine green (ICG) near-infrared angiography in predicting the viability of pedicled intranasal flaps during endoscopic skull base surgery through a pilot study. METHODS ICG near-infrared fluorescence endoscopy was performed during endoscopic endonasal surgery for skull base tumors. Intraoperative and postoperative data were collected regarding enhancement of the flap body and pedicle. Fluorescence was rated qualitatively. Postoperatively, flap perfusion was evaluated via MRI-contrast enhancement in addition to clinical outcomes (cerebrospinal fluid leak and endoscopic flap appearance). RESULTS Thirty-eight patients underwent ICG fluorescence angiography. Both the body and pedicle enhanced in 20 patients (53%), while the pedicle only enhanced for 12 patients (32%), the body only for 3 (8%), and neither for 3 (8%). When both the pedicle and body enhanced with ICG, the rate of postoperative MRI contrast enhancement was 100% and the rate of flap necrosis was 0%. The sensitivity and specificity of flap pedicle ICG enhancement for predicting postoperative flap MRI enhancement were 97% and 67%, respectively. Two of 3 patients without enhancement developed flap necrosis. CONCLUSION ICG fluorescence angiography of intraoperative flap perfusion is feasible and correlates well with outcomes of postoperative MRI flap enhancement and flap necrosis. Additional study is needed to further refine the imaging technique and optimally characterize the clinical utility.

Indocyanine green videoangiography-assisted prediction of flap necrosis in the rat epigastric flap using the flow®800 tool

Microsurgery ◽  
2016 ◽  
Vol 37 (3) ◽  
pp. 235-242 ◽  
Author(s):  
Thomas Mücke ◽  
Andreas M. Fichter ◽  
Leonard H. Schmidt ◽  
David A. Mitchell ◽  
Klaus-Dietrich Wolff ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Flap Necrosis ◽  
Indocyanine Green Videoangiography ◽  
Epigastric Flap

The Ability of Intraoperative Perfusion Mapping with Laser-Assisted Indocyanine Green Angiography To Predict Flap Necrosis in Breast Reconstruction

2013 ◽  
Vol 132 ◽  
pp. 129
Author(s):  
Olushola B. Olorunnipa ◽  
David Goltsman ◽  
Naikhoba C.O. Munabi ◽  
Christine H. Rohde ◽  
Jeffrey A. Ascherman
Keyword(s):  
Breast Reconstruction ◽  
Indocyanine Green ◽  
Indocyanine Green Angiography ◽  
Flap Necrosis

scholarly journals Prediction of Flap Necrosis by Using Indocyanine Green Videoangiography in Cases of Venous Occlusion in the Epigastric Flap Model of the Rat

2018 ◽  
Vol 03 (02) ◽  
pp. e62-e69
Author(s):  
Lucas Ritschl ◽  
Leonard Schmidt ◽  
Andreas Fichter ◽  
Alexander Hapfelmeier ◽  
Anastasios Kanatas ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Venous Occlusion ◽  
Venous Congestion ◽  
Venous Stasis ◽  
Head And Neck Reconstruction ◽  
Flap Necrosis ◽  
Flow Measurements ◽  
Doppler Flowmetry ◽  
Flow 800 ◽  
Epigastric Flap

Background A compromised free flap perfusion attributable to vascular occlusion requires immediate operative correction. Indocyanine green (ICG) videoangiography may reduce the risk of partial skin flap necrosis in high-risk free flaps in patients undergoing head and neck reconstruction. The purpose of this study was to determine the role of ICG in cases of venous congestion in a rat model. Methods A standardized epigastric flap was raised and repositioned in 35 rats. Full venous occlusion of the draining superficial inferior epigastric vein was temporarily applied for 4, 5, 6, or 7 hours. Blood flow measurements including simultaneous laser-Doppler flowmetry and tissue spectrophotometry (oxygen-to-see [O2C]) and ICG videoangiography with the FLOW 800 tool were performed before flap raising, after temporary venous stasis, and after clinical monitoring for 1 week. The Youden index computed from the receiver operating characteristic curve was used to define an optimal cutoff value for necrosis prediction after 4 and 6 hours of stasis. Results The ICG videoangiography with the FLOW 800 tool was found to be superior to O2C in the prediction of flap necrosis. The accuracy of prediction was moderate after an interval of 4 hours of stasis (area under the curve [AUC] = 0.661; 95% confidence interval [CI]: 0.489–0.834) and good after 6 hours of stasis (AUC = 0.787; 95% CI: 0.65–0.915). Conclusions The O2C does not reliably predict tissue necrosis in cases of venous congestion. ICG videoangiography is a valuable tool that can predict clinical outcome and provide guidance on whether to salvage a congested flap.

Prediction of flap necrosis with laser induced indocyanine green fluorescence in a rat model

2005 ◽  
Vol 58 (5) ◽  
pp. 695-701 ◽  
Author(s):  
R.E. Giunta ◽  
T. Holzbach ◽  
C. Taskov ◽  
P.S. Holm ◽  
T. Brill ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Rat Model ◽  
Flap Necrosis ◽  
Green Fluorescence ◽  
Indocyanine Green Fluorescence
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