Emerging role of cellular senescence in the pathogenesis of oral submucous fibrosis and its malignant transformation

Head & Neck ◽  
2021 ◽  
Author(s):  
Mohit Sharma ◽  
Keith D. Hunter ◽  
Felipe Paiva Fonseca ◽  
Raghu Radhakrishnan
Keyword(s):  
Malignant Transformation ◽  
Cellular Senescence ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals The domino effect: Role of hypoxia in malignant transformation of oral submucous fibrosis

2015 ◽  
Vol 19 (2) ◽  
pp. 122 ◽  
Author(s):  
Shree Bajaj ◽  
Minal Chaudhary ◽  
Shruti Bohra ◽  
Nisu Swastika ◽  
Alka Hande
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Domino Effect ◽  
Submucous Fibrosis

Role of hypoxia in malignant transformation of oral submucous fibrosis

2018 ◽  
Vol 13 (1) ◽  
pp. 38 ◽  
Author(s):  
AlkaHarish Hande ◽  
MinalS Chaudhary ◽  
AmolR Gadbail ◽  
PrajaktaR Zade ◽  
MadhuriN Gawande ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mohit Sharma ◽  
Felipe Paiva Fonseca ◽  
Keith D. Hunter ◽  
Raghu Radhakrishnan
Keyword(s):  
Stem Cell ◽  
Malignant Transformation ◽  
Integration Site ◽  
Oral Submucous Fibrosis ◽  
Expression Patterns ◽  
Stem Cell Markers ◽  
Leukaemia Virus ◽  
Cell Markers ◽  
Submucous Fibrosis

Abstract The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous fibrosis (OSF), oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) to understand the role of basal cells in potentiating cancer stem cell behaviour in OSF. While the loss of basal cell clonogenicity triggers epithelial atrophy in OSF, the transition of the epithelium from atrophic to hyperplastic and eventually neoplastic involves the reactivation of basal stemness. The vacillating expression patterns of OM-SCMs confirm the role of keratins 5, 14, 19, CD44, β1-integrin, p63, sex-determining region Y box (SOX2), octamer-binding transcription factor 4 (Oct-4), c-MYC, B-cell-specific Moloney murine leukaemia virus integration site 1 (Bmi-1) and aldehyde dehydrogenase 1 (ALDH1) in OSF, OPMDs and OSCC. The downregulation of OM-SCMs in the atrophic epithelium of OSF and their upregulation during malignant transformation are illustrated with relevant literature in this review.

scholarly journals Conspicuous and frank dilated vascular spaces: A marker of malignant transformation in oral submucous fibrosis

2021 ◽  
Vol 11 (3) ◽  
pp. 365-367
Author(s):  
Sachin C. Sarode ◽  
Gargi S. Sarode ◽  
Namrata Sengupta ◽  
Urmi Ghone ◽  
Shankargouda Patil
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

scholarly journals Identification of a combined biomarker for malignant transformation in oral submucous fibrosis

2016 ◽  
Vol 46 (6) ◽  
pp. 431-438 ◽  
Author(s):  
Shadavlonjid Bazarsad ◽  
Xianglan Zhang ◽  
Ki-Yeol Kim ◽  
Rasika Illeperuma ◽  
Ruwan D Jayasinghe ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis
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