Sinonasal adenocarcinoma: A population‐based analysis of demographic and socioeconomic disparities

Head & Neck ◽  
2021 ◽  
Author(s):  
Christopher M. Low ◽  
Karthik Balakrishnan ◽  
Byron M. Smith ◽  
Janalee K. Stokken ◽  
Erin K. O'Brien ◽  
...  
Keyword(s):  
Population Based ◽  
Socioeconomic Disparities ◽  
Sinonasal Adenocarcinoma

scholarly journals Socioeconomic disparities in breast cancer incidence and survival among parous women: findings from a population-based cohort, 1964–2008

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Mandy Goldberg ◽  
Ronit Calderon-Margalit ◽  
Ora Paltiel ◽  
Wiessam Abu Ahmad ◽  
Yechiel Friedlander ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Population Based ◽  
Socioeconomic Disparities

scholarly journals Treatment of Sinonasal Adenocarcinoma: A Population-Based Prospective Cohort Study

2019 ◽  
Vol 81 (06) ◽  
pp. 627-637 ◽  
Author(s):  
Marton König ◽  
Terje Osnes ◽  
Åse Bratland ◽  
Peter Jebsen ◽  
Torstein R. Meling
Keyword(s):  
Prospective Cohort ◽  
Multidisciplinary Treatment ◽  
Survival Rates ◽  
Population Based ◽  
Craniofacial Resection ◽  
Curative Intent ◽  
Term Survival ◽  
Entire Cohort ◽  
Sinonasal Adenocarcinoma

Abstract Objectives Sinonasal adenocarcinoma (AC) is a potentially curable disease despite being an aggressive malignancy. Long-term survival can be achieved with early diagnosis and adequate multidisciplinary treatment. Our goal was to evaluate outcomes for patients with AC treated at our institution. Design In a population-based consecutive prospective cohort, we conducted an analysis of all patients treated for surface epithelial AC between 1995 and 2018. Results Twenty patients were included, and follow-up was 100%. The mean follow-up time was 89 months for the entire cohort (112 months for patients with no evidence of disease). Intestinal-type AC was found in 65%, whereas nonintestinal-type AC was found in 35% of all cases; 75% had stage T3/4 disease. Tumor grade was intermediate/high in 65%. Eighteen patients underwent treatment with curative intent (craniofacial resection [CFR] in 61%, transfacial approach in 39%, adjuvant radiotherapy in 89%), achieving negative margins in 56% of cases. Overall survival (OS) rates were 90, 68, and 54% after 2, 5, and 10 years of follow-up, respectively, and the corresponding disease-specific survival (DSS) rates were 90, 73, and 58%. Age over 60 years, tumor with a maxillary origin, and microscopic bone invasion were negative prognostic factors. Radical CFR was correlated with better OS and DSS. Conclusion The high probability of achieving radicality with CFR, the low complication rate, the acceptable toxicity of modern irradiation modalities, and the promising survival rates indicate that this strategy might be considered a safe and an effective option for treating patients with very advanced sinonasal AC.

Cancer of unknown primary (CUP): A population-based analysis of temporal change and socioeconomic disparities.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17535-e17535
Author(s):  
Damien Urban ◽  
Aparna Rao ◽  
Mathias Bressel ◽  
Yaacov Richard Lawrence ◽  
Linda R. Mileshkin
Keyword(s):  
Recent Decade ◽  
Population Based ◽  
Socioeconomic Disparities ◽  
Unknown Primary ◽  
Histologic Diagnosis ◽  
Entire Cohort ◽  
Improvement In Survival ◽  
Tumour Characteristics ◽  
Over Time ◽  
Diagnostic Investigations

e17535 Background: CUP is the 4th most common cause of cancer death. With advanced diagnostic investigations and treatment of cancer, we hypothesized that the proportion of cancers diagnosed as CUP and survival outcomes of CUP have changed and examination of these changes may identify socioeconomic disparities in the US. Methods: We analysed trends in CUP diagnosis and outcome within the SEER registry between 1973-2008. The relationship between demographic and tumour characteristics with survival was investigated. Results: The incidence and percentage of all cancers diagnosed as CUP have decreased over time (incidence 8.9 vs 6.2 per 100,000 and percentage 3.9% vs 1.9% of all cancer diagnoses in 1973 vs 2008 respectively). Significantly more females were labelled as CUP without a pathological confirmation (25% vs 20% in males, p<0.001). A higher proportion of CUP was diagnosed in females, blacks and residents of less affluent or less educated counties. The 5 year survival significantly improved in those with squamous histology (SqC) but only marginally in those with non-SqC CUP. The improvement in survival over time within SqCC was more pronounced among some socioeconomic groups (SEG; Table). For the entire cohort, factors associated with a longer survival on multivariate analysis included: white race; female; <65 years old; most recent decade at diagnosis; grade 1; SqC; married; a histologic diagnosis and treatment with radiotherapy (all p<0.001). Despite the improvement in survival with radiotherapy (RT), the use of RT was less frequent in females and blacks. Conclusions: The percentage of cancers diagnosed as CUP is decreasing but prognosis remains poor, particularly in non-SqCC CUP. However, significant disparities in the diagnosis and survival between SEG exist, suggesting inequalities in access to diagnostic investigations and treatment. [Table: see text]

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