High‐risk early‐stage oral tongue squamous cell carcinoma, when free margins are not enough: Critical review

Head & Neck ◽  
2021 ◽  
Author(s):  
Andrea Galli ◽  
Stefano Bondi ◽  
Carla Canevari ◽  
Michele Tulli ◽  
Leone Giordano ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Critical Review ◽  
Early Stage ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue

scholarly journals Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Jiajia Li ◽  
Shan Liu ◽  
Zhangao Li ◽  
Xinxin Han ◽  
Lin Que
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Locoregional Recurrence ◽  
Perineural Invasion ◽  
Early Stage ◽  
Tongue Squamous Cell Carcinoma ◽  
Sensitivity Analyses ◽  
Cochrane Library ◽  
Oral Tongue

ObjectivesA significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI.Materials and MethodsPubMed, Embase, and the Cochrane Library were queried for potentially eligible articles published up to December 2020. The primary outcomes were the hazard ratio (HR) for locoregional recurrence, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The random-effect model was used in all analyses.ResultsSeventeen studies (4445 patients) were included. Using adjusted HRs, the presence of PNI was associated with a higher risk of locoregional recurrence (HR=1.73, 95%CI: 1.07-2.79, P=0.025, I2 = 33.1%, Pheterogeneity=0.224), worse OS (HR=1.94, 95%CI: 1.39-2.72, P<0.001, I2 = 0.0%, Pheterogeneity=0.838), worse DFS (HR=2.13, 95%CI: 1.53-2.96, P<0.001, I2 = 48.4%, Pheterogeneity=0.071), and worse CSS (HR=1.93, 95%CI: 1.40-2.65, P<0.001, I2 = 25.5%, Pheterogeneity=0.251). PNI had an impact on locoregional recurrence in early-stage OTSCC but not in all stages, and on OS, DFS, and CSS in all-stage and early-stage OTSCC. The sensitivity analyses showed that the results were robust.ConclusionThe presence of PNI significantly affects the locoregional recurrence and survival outcomes among patients with OTSCC.

scholarly journals Cytokeratin 4 is a novel predictive marker in early stage (T1/2) oral tongue squamous cell carcinoma (TSCC)

2016 ◽  
Vol 27 ◽  
pp. vi334
Author(s):  
T. Enokida ◽  
S. Fujii ◽  
M. Takahashi ◽  
T. Wakasugi ◽  
T. Yamazaki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Predictive Marker ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Stage T1

Anatomically‐based transoral surgical approach to early‐stage oral tongue squamous cell carcinoma

Head & Neck ◽  
2020 ◽  
Vol 42 (5) ◽  
pp. 1105-1109 ◽  
Author(s):  
Luca Calabrese ◽  
Giacomo Pietrobon ◽  
Enrico Fazio ◽  
Monir Abousiam ◽  
Shadi Awny ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Approach ◽  
Early Stage ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue
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