Correlation of focal adhesion kinase expression with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

Head & Neck ◽  
2018 ◽  
Vol 41 (5) ◽  
pp. 1290-1296 ◽  
Author(s):  
Pablo Munguía‐Calzada ◽  
Iván Fernández‐Vega ◽  
Pablo Martínez‐Camblor ◽  
Susana Díaz‐Coto ◽  
Juana María García‐Pedrero ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Nodal Metastasis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Focal Adhesion Kinase Expression ◽  
Kinase Expression

Involvement of focal adhesion kinase in cellular proliferation, apoptosis and prognosis of laryngeal squamous cell carcinoma

2012 ◽  
Vol 126 (11) ◽  
pp. 1127-1133 ◽  
Author(s):  
D W Li ◽  
Y J Sun ◽  
Z F Sun ◽  
P Dong
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Cell Apoptosis ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Focal Adhesion Kinase Expression ◽  
Kinase Expression

AbstractObjective:This study aimed to investigate the relationship between focal adhesion kinase expression and clinicopathological factors, cell apoptosis and proliferation, and overall survival, in laryngeal squamous cell carcinoma.Methods:Immunohistochemical staining was used to detect the expression of focal adhesion kinase and proliferating cell nuclear antigen in tissue samples. Apoptotic cells were assessed using the terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate nick end labelling (‘TUNEL’) method.Results:The proportion of focal adhesion kinase expression was 73.26 per cent in tumour tissues, significantly greater than in normal tissues (p < 0.05), and was significantly related to laryngeal cancer clinical stage, lymph node metastasis and overall survival (p < 0.05). In the tumour cases assessed, up-regulation of focal adhesion kinase expression was significantly associated with decreased cell apoptosis and increased proliferation (p < 0.05).Conclusion:These findings suggest that focal adhesion kinase may affect laryngeal squamous cell carcinoma progression through regulation of cell apoptosis and proliferation. Focal adhesion kinase expression is a major prognostic factor in laryngeal cancer patients.

P-113 Oncological Outcomes and Prognostication in Cutaneous Squamous Cell Carcinoma of the Head and Neck with Nodal Metastasis

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 1
Author(s):  
Mark D. Wilkie ◽  
Dorota Chudek ◽  
Sankalap Tandon ◽  
Christopher Loh ◽  
Nicholas J. Roland ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Nodal Metastasis ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Oncological Outcomes

Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck

2017 ◽  
Vol 77 (3) ◽  
pp. 527-533 ◽  
Author(s):  
Juana María García-Pedrero ◽  
Pablo Martínez-Camblor ◽  
Susana Diaz-Coto ◽  
Pablo Munguia-Calzada ◽  
Aitana Vallina-Alvarez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Nodal Metastasis ◽  
Cutaneous Squamous Cell Carcinoma

scholarly journals Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number

2006 ◽  
Vol 12 (11) ◽  
pp. 3272-3279 ◽  
Author(s):  
Marta Canel ◽  
Pablo Secades ◽  
Juan-Pablo Rodrigo ◽  
Rubén Cabanillas ◽  
Agustín Herrero ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Squamous Cell ◽  
Copy Number ◽  
Gene Copy Number ◽  
Neck Squamous Cell Carcinoma ◽  
Gene Copy

Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma

2019 ◽  
Vol 311 (5) ◽  
pp. 369-376 ◽  
Author(s):  
J. Santos-Juanes ◽  
I. Fernández-Vega ◽  
S. Lorenzo-Herrero ◽  
C. Sordo-Bahamonde ◽  
P. Martínez-Camblor ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Nodal Metastasis ◽  
Cutaneous Squamous Cell Carcinoma
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