Preoperative assessment of CD44‐mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma

Head & Neck ◽  
2018 ◽  
Vol 41 (4) ◽  
pp. 950-958 ◽  
Author(s):  
Grégoire B. Morand ◽  
Kristian Ikenberg ◽  
Domenic G. Vital ◽  
Isabel Cardona ◽  
Holger Moch ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Preoperative Assessment ◽  
Depth Of Invasion ◽  
Occult Metastases

scholarly journals Evaluation of Depth of Invasion in Oral Squamous Cell Carcinoma with Ultra-High Frequency Ultrasound: A Preliminary Study

2021 ◽  
Vol 11 (16) ◽  
pp. 7647
Author(s):  
Rossana Izzetti ◽  
Marco Nisi ◽  
Stefano Gennai ◽  
Teresa Oranges ◽  
Laura Crocetti ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Frequency ◽  
Preoperative Assessment ◽  
Depth Of Invasion ◽  
High Frequency Ultrasound ◽  
Ultra High Frequency ◽  
Frequency Ultrasound

Intraoral ultrasonography has been widely employed for the preoperative assessment of tumor margins due to its capability to evaluate depth of invasion (DOI) and tumor thickness (TT). Recently, a novel ultrasonographic technique, ultra-high frequency ultrasound (UHFUS) has been increasingly applied to the study of oral lesions. This study evaluates the potential application of intraoral UHFUS to assess DOI and TT parameters of oral squamous cell carcinoma (OSCC) lesions. Patients clinically suspected of OSCC lesions were enrolled and underwent an intraoral UHFUS examination preoperatively. The parameters of TT, DOI, echogenicity, and vascularization were assessed. The parameters of TT and DOI as evaluated by means of UHFUS were compared to histology, which was set as the benchmark. Ten patients in total were enrolled. UHFUS-based DOI and TT measurements were found to positively correlate with histology (p < 0.05), although UHFUS provided a slight overestimation of DOI. No differences were found in terms of echogenicity or vascularization depending on the site of the lesion. According to these preliminary results, UHFUS could support the preoperative assessment of TT and DOI, potentially enhancing the clinical evaluation of OSCC.

Tumor depth of invasion and prognosis of early‐stage oral squamous cell carcinoma: A meta‐analysis

Oral Diseases ◽  
2019 ◽  
Vol 26 (7) ◽  
pp. 1357-1365 ◽  
Author(s):  
Patrícia Carlos Caldeira ◽  
Andrea María López Soto ◽  
Maria Cássia Ferreira Aguiar ◽  
Carolina Castro Martins
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Meta Analysis ◽  
Depth Of Invasion ◽  
Tumor Depth

scholarly journals Intraoral Ultrasound in the Evaluation of Depth of Invasion in OSCC. Preliminary Results

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 28
Author(s):  
Graniero ◽  
D’Alessandro ◽  
Montori ◽  
Rocchetti ◽  
Cantisani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Surgical Treatment ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphatic Spread ◽  
Depth Of Invasion ◽  
Preliminary Results

Oral Squamous Cell Carcinoma (OSCC) shows an early tendency to lymphatic spread rather than hematogenous. The surgical treatment cannot be considered oncologically complete if the neck is not evaluated [1]. [...]

scholarly journals The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Esam Ahmad Omar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Oral Cancer ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Imaging Techniques ◽  
Publication Date ◽  
Depth Of Invasion ◽  
Tumour Thickness

Objective. Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Data Sources. A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, prognostic factors of oral cancer, diagnostic method of oral cancer, and imaging techniques for diagnosis of oral cancer. The search was restricted to articles published in English, with no publication date restriction (last update April, 2013). Review Methods. In this paper, I approach the factors of prognosis of OSCC and the new advances in diagnostic technologies as well. I also reviewed available studies of the tissue fluorescence spectroscopy and other noninvasive diagnostic aids for OSCC. Results. The outcome is greatly influenced by the stage of the disease (especially TNM). Prognosis also depends or varies with tumour primary site, nodal involvement, tumour thickness, and the status of the surgical margins. Conclusion. Tumour diameter is not the most accurate when compared to tumour thickness or depth of invasion, which can be related directly to prognosis. There is a wide agreement on using ultrasound guided fine needle aspiration biopsies in the evaluation of lymph node metastasis.

O155. The presence of occult metastases in non-sentinel lymph node in oral squamous cell carcinoma

2009 ◽  
Vol 3 (1) ◽  
pp. 107
Author(s):  
A.C. Christensen ◽  
A.B. Bilde ◽  
M.H.T. Therkildsen ◽  
B.C. Charabi ◽  
J.K. Kirkegaard ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Occult Metastases
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