Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification

Head & Neck ◽  
2016 ◽  
Vol 38 (9) ◽  
pp. 1407-1415 ◽  
Author(s):  
Maxime Mermod ◽  
Massimo Bongiovanni ◽  
Tatiana V. Petrova ◽  
Elena A. Dubikovskaya ◽  
Christian Simon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Node Metastasis ◽  
Homeobox Protein ◽  
Occult Lymph Node Metastasis

Prediction of Occult Lymph Node Metastasis in Head and Neck Cancer with CD31 Vessel Quantification

2018 ◽  
Vol 160 (2) ◽  
pp. 277-283 ◽  
Author(s):  
Maxime Mermod ◽  
Massimo Bongiovanni ◽  
Tatiana Petrova ◽  
Elena Goun ◽  
Christian Simon ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Predictive Value ◽  
Microvascular Density ◽  
Node Metastasis ◽  
Occult Lymph Node Metastasis

Objective The management of occult lymph node metastasis (LNM) in head and neck squamous cell carcinoma has been a matter of controversy for decades. The vascular density within the tumor microenvironment, as an indicator of ongoing angiogenesis, could constitute an attractive predictor of LNM. The use of the panvascular endothelial antibody CD31 as a marker of occult LNM has never been reported. The aim of this study was to assess the predictive value of CD31 microvascular density for the detection of occult LNM in squamous cell carcinoma of the oral cavity and oropharynx. Study Design Case series with chart review. Setting Tertiary university hospital. Subjects and Methods Intra- and peritumoral microvascular density values were determined in 56 cases of squamous cell carcinoma of the oral cavity (n = 50) and oropharynx (n = 6) with clinically negative necks using the CD31 marker. Statistical associations of CD31 microvascular densities with clinicopathologic data were then established. Results Peritumoral CD31 microvascular density was significantly associated with occult LNM in multivariate analysis ( P < .01). Recursive partitioning analysis for this parameter found a cutoff of 19.33, which identified occult LNM with a sensitivity of 91%, a specificity of 65%, a positive predictive value of 40%, a negative predictive value of 97%, and an overall diagnostic accuracy of 71%. Conclusion Peritumoral CD31 microvascular density in primary squamous cell carcinoma of the oral cavity and oropharynx allows accurate prediction of occult LNM.

scholarly journals Oral cavity squamous cell carcinoma: factors related to occult lymph node metastasis

2015 ◽  
Vol 81 (3) ◽  
pp. 248-254 ◽  
Author(s):  
André Fernandes d’Alessandro ◽  
Fábio Roberto Pinto ◽  
Chin Shien Lin ◽  
Marco Aurélio Vamondes Kulcsar ◽  
Cláudio Roberto Cernea ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Node Metastasis ◽  
Occult Lymph Node Metastasis

Association of CCL2 with Lymph Node Metastasis and Macrophage Infiltration in Oral Cavity and Lip Squamous Cell Carcinoma

Tumor Biology ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 114-121 ◽  
Author(s):  
Fernanda Oliveira Ferreira ◽  
Fernanda Luiza Leite Ribeiro ◽  
Aline Carvalho Batista ◽  
Cl&aacute;udio Rodrigues Leles ◽  
Rita de Cassia Goncalves Alencar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Macrophage Infiltration ◽  
Node Metastasis
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