Intensity-modulated proton therapy for nasopharyngeal carcinoma: Decreased radiation dose to normal structures and encouraging clinical outcomes

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E1886-E1895 ◽  
Author(s):  
Gary D. Lewis ◽  
Emma B. Holliday ◽  
Esengul Kocak-Uzel ◽  
Mike Hernandez ◽  
Adam S. Garden ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Radiation Dose ◽  
Clinical Outcomes ◽  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

scholarly journals Early Clinical Outcomes by Combination of Intensity Modulated Radiation Therapy and Intensity Modulated Proton Therapy in Treating Oropharynx Cancer Patients

2021 ◽  
Author(s):  
Han Gyul Yoon ◽  
Yong Chan Ahn ◽  
Dongryul Oh ◽  
Jae Myoung Noh ◽  
Seung Kyu Park ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Clinical Outcomes ◽  
Proton Therapy ◽  
Intensity Modulated Radiation Therapy ◽  
Combination Group ◽  
Intensity Modulated Proton Therapy ◽  
Oropharynx Cancer ◽  
Intensity Modulated ◽  
Before And After ◽  
Early Clinical Outcomes

Purpose: To report the early clinical outcomes of combining intensity‐modulated radiation therapy (IMRT) and intensity‐modulated proton therapy (IMPT) in comparison with IMRT alone in treating the oropharynx cancer (OPC) patients. Materials and Methods: The medical records of 148 OPC patients were retrospectively reviewed, who underwent definitive radiotherapy (RT) with concurrent systemic therapy, from January 2016 till December 2019 at Samsung Medical Center. During the 5.5 weeks’ RT course, the initial 16 (or 18) fractions were delivered by IMRT in all patients, and the subsequent 12 (or 10) fractions were either by IMRT in 81 patients (IMRT only) or by IMPT in 67 (IMRT/IMPT combination), respectively, based on comparison of adaptive re-plan profiles and availability of equipment. Propensity‐score matching (PSM) was done on 76 patients (38 from each group) for comparative analyses. Results: With the median follow‐up of 24.7 months, there was no significant difference in overall survival and progression free survival between groups, both before and after PSM. Before PSM, IMRT/IMPT combination group experienced grade ≥3 acute toxicities less frequently: mucositis in 37.0% and 13.4% (p<0.001); and analgesic quantification algorithm (AQA) in 37.0% and 19.4% (p=0.019), respectively. The same trends were observed after PSM: mucositis in 39.5% and 15.8% (p=0.021); and AQA in 47.4% and 21.1% (p=0.016), respectively. In multivariate logistic regression, grade ≥3 mucositis was significantly less frequent in IMRT/IMPT combination group, both before and after PSM (p=0.027 and 0.024, respectively). AQA score ≥3 was also less frequent in IMRT/IMPT combination group, both before and after PSM (p=0.085 and 0.018, respectively). Conclusions: In treating the OPC patients, with comparable early oncologic outcomes, more favorable acute toxicity profiles were achieved following IMRT/IMPT combination than IMRT alone.

Comparison of intensity-modulated proton therapy and intensity-modulated photon therapy in treatment of nasopharyngeal carcinoma

2007 ◽  
Vol 82 ◽  
pp. S52-S53
Author(s):  
Z. Taheri-Kadkhoda ◽  
S. Nill ◽  
J. Wilkens ◽  
U. Oelfke ◽  
T. Björk-Eriksson ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated

scholarly journals Significant Reduction in Vertebral Artery Dose by Intensity Modulated Proton Therapy: A Pilot Study for Nasopharyngeal Carcinoma

2021 ◽  
Vol 11 (8) ◽  
pp. 822
Author(s):  
Yun-Hsuan Lin ◽  
Jen-Yu Cheng ◽  
Bing-Shen Huang ◽  
Sheng-Dean Luo ◽  
Wei-Che Lin ◽  
...  
Keyword(s):  
Pilot Study ◽  
Nasopharyngeal Carcinoma ◽  
Vertebral Artery ◽  
Proton Therapy ◽  
Organs At Risk ◽  
Patient Treatment ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Adequate Dose ◽  
Target Volumes

Intensity modulated proton therapy (IMPT) with the vertebral artery (VA)-sparing technique has been initially proposed in our institution. This pilot study was conducted to compare the dose to VAs between IMPT and volumetric-modulated arc therapy (VMAT) for patients with nasopharyngeal carcinoma (NPC). A total of six patients with NPC treated by IMPT were enrolled in the study. Target volumes and organs at risk (OARs) were delineated, including 12 samples of right and left VAs, respectively, for each patient. Treatment planning by IMPT and dual-arc VMAT was carried out for comparison. The IMPT plan significantly reduced VA mean dose, V10, V20, V30, V40, and V50, compared to the VMAT plan in all 12 samples (p < 0.001). The average mean dose to VAs for IMPT was 35.2% (23.4–46.9%), which was less compared to VMAT (p < 0.001). Adequate dose coverage was achieved with both IMPT and VMAT plans for three different dose levels of target volumes for all patients. IMPT significantly reduces VA dose while maintaining adequate dose coverage of all target volumes. For patients with head and neck cancer who seek to preserve their blood flow to the brain in order to decrease late vascular and neurologic sequelae, IMPT should be considered. A prospective study with longer follow-up is ongoing to confirm our preliminary results.

scholarly journals Early clinical outcomes of helical tomotherapy/intensity‐modulated proton therapy combination in nasopharynx cancer

2019 ◽  
Vol 110 (9) ◽  
pp. 2867-2874 ◽  
Author(s):  
Seung Gyu Park ◽  
Yong Chan Ahn ◽  
Dongryul Oh ◽  
Jae Myoung Noh ◽  
Sang Gyu Ju ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Proton Therapy ◽  
Helical Tomotherapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated ◽  
Nasopharynx Cancer ◽  
Early Clinical Outcomes

scholarly journals OC-0119: Comparison of intensity modulated proton therapy versus rotational IMRT for nasopharyngeal carcinoma

2015 ◽  
Vol 115 ◽  
pp. S56-S57
Author(s):  
T. Williams ◽  
Y. Roussakis ◽  
P. Sanghera ◽  
A. Hartley ◽  
G. Heyes ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Proton Therapy ◽  
Intensity Modulated Proton Therapy ◽  
Intensity Modulated
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