Near infrared fluorescent imaging after intravenous injection of indocyanine green during neck dissection in patients with head and neck cancer: A feasibility study

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E1833-E1837 ◽  
Author(s):  
Antoine Digonnet ◽  
Sophie van Kerckhove ◽  
Michel Moreau ◽  
Esther Willemse ◽  
Marie Quiriny ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Indocyanine Green ◽  
Head And Neck ◽  
Neck Dissection ◽  
Intravenous Injection ◽  
Feasibility Study ◽  
Neck Cancer ◽  
Near Infrared ◽  
Fluorescent Imaging

scholarly journals Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Naoki Nishio ◽  
Nynke S. van den Berg ◽  
Stan van Keulen ◽  
Brock A. Martin ◽  
Shayan Fakurnejad ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Molecular Imaging ◽  
Head And Neck ◽  
Neck Dissection ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Near Infrared ◽  
Elective Neck Dissection ◽  
Fluorescence Signal ◽  
The Impact

Abstract Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

scholarly journals Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

2020 ◽  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Multicenter Study ◽  
Performance Status ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
N Stage

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.

scholarly journals Effectiveness of nivolumab affected by prior cetuximab use and neck dissection in Japanese patients with recurrent or metastatic head and neck cancer: results from a retrospective observational study in a real-world setting

2021 ◽  
Author(s):  
Shin Kariya ◽  
Yasushi Shimizu ◽  
Nobuhiro Hanai ◽  
Ryuji Yasumatsu ◽  
Tomoya Yokota ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Median Overall Survival ◽  
Response Rate ◽  
Objective Response ◽  
Progression Free Survival ◽  
Japanese Patients ◽  
Free Survival

Abstract Background To examine the effect of prior use of cetuximab and neck dissection on the effectiveness of nivolumab, we conducted a large-scale subgroup analysis in Japanese patients with recurrent/metastatic head and neck cancer. Methods Data on the effectiveness of nivolumab were extracted from patient medical records. All patients were analyzed for effectiveness by prior cetuximab use. In the analyses for prior neck dissection, only patients with locally advanced disease were included. Results Of 256 patients analyzed, 155 had received prior cetuximab. Nineteen of 50 patients with local recurrence underwent neck dissection. The objective response rate was 14.7 vs 17.2% (p = 0.6116), median progression-free survival was 2.0 vs 3.1 months (p = 0.0261), and median overall survival was 8.4 vs 12 months (p = 0.0548) with vs without prior cetuximab use, respectively. The objective response rate was 23.1 vs 25.9% (p = 0.8455), median progression-free survival was 1.8 vs 3.0 months (p = 0.6650), and median overall survival was 9.1 vs 9.9 months (p = 0.5289) with vs without neck dissection, respectively. Conclusions These findings support the use of nivolumab for patients with recurrent/metastatic head and neck cancer regardless of prior cetuximab use or neck dissection history. Trial registration number UMIN-CTR (UMIN000032600), Clinicaltrials.gov (NCT03569436)

Assessment of indocyanine green–labeled cetuximab to detect xenografted head and neck cancer cell lines

2007 ◽  
Vol 137 (5) ◽  
pp. 729-734 ◽  
Author(s):  
Kirk P. Withrow ◽  
John P. Gleysteen ◽  
Ahmad Safavy ◽  
Joni Skipper ◽  
Renee A. Desmond ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Indocyanine Green ◽  
Head And Neck ◽  
Cell Lines ◽  
Cancer Cell ◽  
Neck Cancer ◽  
Cancer Cell Lines

The Role of Neck Dissection after Radical Chemoradiation for Locally Advanced Head and Neck Cancer: Should We Move Back

Oncology ◽  
2013 ◽  
Vol 84 (3) ◽  
pp. 174-185 ◽  
Author(s):  
N. Denaro ◽  
E.G. Russi ◽  
G. Numico ◽  
T. Pazzaia ◽  
R. Vitiello ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head

scholarly journals Role of near-infrared fluorescence imaging in head and neck cancer surgery: from animal models to humans

2014 ◽  
Vol 272 (10) ◽  
pp. 2593-2600 ◽  
Author(s):  
Ihab Atallah ◽  
Clément Milet ◽  
Jean-Luc Coll ◽  
Emile Reyt ◽  
Christian Adrien Righini ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Animal Models ◽  
Head And Neck ◽  
Fluorescence Imaging ◽  
Neck Cancer ◽  
Near Infrared ◽  
Cancer Surgery ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging
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