scholarly journals External beam radiotherapy in differentiated thyroid carcinoma: A systematic review

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E2297-E2305 ◽  
Author(s):  
Jonathan M. Fussey ◽  
Rosa Crunkhorn ◽  
Miroslav Tedla ◽  
Martin O. Weickert ◽  
Hisham Mehanna
Keyword(s):  
Systematic Review ◽  
Thyroid Carcinoma ◽  
External Beam Radiotherapy ◽  
Differentiated Thyroid Carcinoma ◽  
External Beam

The Role of postoperative external beam radiotherapy for differentiated thyroid carcinoma: A Systematic review and meta‐analysis

Head & Neck ◽  
2020 ◽  
Vol 42 (8) ◽  
pp. 2181-2193
Author(s):  
Luisa E. Jacomina ◽  
JC Kennetth M. Jacinto ◽  
Lester Bryan A. Co ◽  
Kelvin Ken L. Yu ◽  
Ryan Anthony F. Agas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Thyroid Carcinoma ◽  
Meta Analysis ◽  
External Beam Radiotherapy ◽  
Differentiated Thyroid Carcinoma ◽  
External Beam

scholarly journals Locoregional disease control after external beam radiotherapy in 91 patients with differentiated thyroid carcinoma and pT4 tumor stage - a single institution experience

2018 ◽  
Vol 52 (4) ◽  
pp. 453-460 ◽  
Author(s):  
Nikola Besic ◽  
Marta Dremelj ◽  
Gasper Pilko
Keyword(s):  
Thyroid Carcinoma ◽  
Multimodal Treatment ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Differentiated Thyroid Carcinoma ◽  
Locoregional Control ◽  
External Beam ◽  
Regional Metastases ◽  
Disease Free

Abstract Background Locoregional recurrence is common in patients with locally advanced differentiated thyroid carcinoma (DTC). Our aim was to find out the rate of locoregional control of the disease after external beam radiotherapy (EBRT) of the neck and mediastinum in patients with DTC and pT4 tumor. Patients and methods Altogether 91 patients (47 males, 44 females, median age 61 years) with DTC had EBRT of the neck and mediastinum as part of the multimodal treatment of pT4 tumor (63 cases pT4a, 28 cases pT4b) from the year 1973 to 2015. Data on clinical factors, histopathology and recurrence were collected. Disease-free, disease-specific and overall survival was calculated. Results Median tumor size was 5 cm (range 1–30 cm). Out of 91 patients, 23 had distant and 38 regional metastases. A total or near-total thyroidectomy, lobectomy, subtotal thyroidectomy and lymph node dissection was performed in 70%, 14%, 2% and 30% of cases, respectively. Thirteen percent of patients were not treated with surgery. All patients had EBRT and 39 had chemotherapy. Radioiodine (RAI) ablation of thyroid remnant and RAI therapy was applied in 90% and 40% of cases, respectively. Recurrence was diagnosed in 29/64 patients without a persistent disease: locoregional and distant in 16 and 13 cases, respectively. Five-year and ten-year disease-free survival rate was 64% and 48%, respectively. Conclusions The majority of patients with DTC and pT4 tumors who were treated with EBRT of the neck and mediastinum region as part of multimodal treatment have long-lasting locoregional control of the disease.

scholarly journals EP-1167: Indications for external beam radiotherapy in differentiated thyroid carcinoma: an expert consensus

2018 ◽  
Vol 127 ◽  
pp. S653-S654
Author(s):  
E. Blais ◽  
P. Lagarde ◽  
B. Henriques de Figueiredo ◽  
B. Nicolescu-Catargi ◽  
O. Schneegans ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
External Beam Radiotherapy ◽  
Differentiated Thyroid Carcinoma ◽  
Expert Consensus ◽  
External Beam

Multicenter Study Differentiated Thyroid Carcinoma (MSDS)

2003 ◽  
Vol 42 (06) ◽  
pp. 244-250 ◽  
Author(s):  
M. K. Pixberg ◽  
A. Schuck ◽  
A. Heinecke ◽  
W. Köpcke ◽  
K. W. Schmid ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Randomized Trial ◽  
Multicenter Study ◽  
External Beam Radiotherapy ◽  
Differentiated Thyroid Carcinoma ◽  
Steering Committee ◽  
Clinical Event ◽  
External Beam ◽  
Thyroxine Therapy ◽  
Number Of Patients

Summary Aim: The Multicenter Study Differentiated Thyroid Carcinoma (MSDS) is an ongoing study in Germany, Austria, and Switzerland on the clinical benefit of adjuvant external beam radiotherapy (RTx) for locally invasive differentiated thyroid carcinoma (DTC) in TNM stages pT4 pN0/1/x M0/x (5th ed. 1997). Methods: MSDS was designed as a prospective randomized trial. Patients receive thyroidectomy, radioiodine therapy (RIT) to ablate the thyroid remnant, and TSH-suppressive L-thyroxine therapy with or without RTx after documented elimination of cervical iodine-131 uptake (http://msdsstudie.uni-muenster.de). Results: 311 patients were enrolled between January 2000 and March 2003. 279 patients met the trial’s inclusion criteria. 45 consented to randomization, of whom 17 were randomized into treatment arm A (RTx) and 18 into arm B (no RTx).Advised by the trial’s independent Data Monitoring and Safety Committee, the MSDS steering committee decided to terminate randomization in April 2003 and continue MSDS as a prospective cohort study. 23 of the 234 patients in the observation arm of the trial were prescribed RTx by their physicians. Thus, 14% of the trial cohort were randomized or assigned to receive RTx (intention-to-treat analysis). In contrast, at least 44% of all patients with pT4 papillary DTC in Germany in the nationwide PCES study underwent RTx in 1996 (p <0.001, χ2-test). Conclusions: Acceptance of external beam RTx as a treatment modality for DTC has receded to a degree that accrual of a sufficient number of patients for a randomized trial has been impossible. Observation of the trial cohort is continued in order to assess clinical event rates with and without RTx and chronic RTx toxicity.

scholarly journals 220: Patterns of Recurrence After External Beam Radiotherapy for Anaplastic And Differentiated Thyroid Carcinoma

2016 ◽  
Vol 120 ◽  
pp. S80 ◽  
Author(s):  
Horia Vulpe ◽  
Jennifer Kwan ◽  
Andrea McNiven ◽  
James Brierley ◽  
Richard Tsang ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
External Beam Radiotherapy ◽  
Differentiated Thyroid Carcinoma ◽  
External Beam ◽  
Patterns Of Recurrence

Quality of Life Impact of External Beam Radiotherapy for Advanced Thyroid Carcinoma

Thyroid ◽  
2013 ◽  
Vol 23 (1) ◽  
pp. 64-69 ◽  
Author(s):  
Thomas J. Gal ◽  
Michele Streeter ◽  
Jessica Burris ◽  
Mahesh Kudrimoti ◽  
Kenneth B. Ain ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Thyroid Carcinoma ◽  
External Beam Radiotherapy ◽  
External Beam ◽  
Life Impact
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