Good tolerance and long-term complete remission after definitive intensity-modulated radiotherapy for locally advanced head and neck cancer in a patient with human immunodeficiency virus infection: A case report and literature review

Head & Neck ◽  
2015 ◽  
Vol 37 (12) ◽  
pp. E186-E190 ◽  
Author(s):  
Wan-Yu Chen ◽  
Sung-Hsin Kuo ◽  
Chia-Wei Shen ◽  
Bing-Shen Huang ◽  
Keng-Hsueh Lan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Head And Neck Cancer ◽  
Case Report ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Good Tolerance ◽  
Intensity Modulated ◽  
Immunodeficiency Virus

Residual deficits in quality of life one year after intensity-modulated radiotherapy for patients with locally advanced head and neck cancer

2015 ◽  
Vol 191 (6) ◽  
pp. 501-510 ◽  
Author(s):  
Silke Tribius ◽  
Marieclaire Raguse ◽  
Christian Voigt ◽  
Adrian Münscher ◽  
Alexander Gröbe ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Intensity Modulated ◽  
One Year

scholarly journals Moderately Hypofractionated Intensity Modulated Radiotherapy (IMRT) With a Simultaneous Integrated Boost for Locally Advanced Head and Cancer – Do Modern Techniques Held Their Promise?

2021 ◽  
Author(s):  
Jörn Wichmann ◽  
Martin Durisin ◽  
Robert Michael Hermann ◽  
Roland Merten ◽  
Hans Christiansen
Keyword(s):  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Simultaneous Integrated Boost ◽  
Advanced Head ◽  
Intensity Modulated ◽  
Regional Control ◽  
Integrated Boost ◽  
Long Term Follow Up

Abstract PurposeIntensity-modulated-radiotherapy (IMRT) is still a standard of care for radiotherapy in locally advanced head and neck cancer (LA-HNSCC). Simultaneous-integrated-boost (SIB) and moderately hypofractionation offer an opportunity of individual dose painting and reduction of overall treatment time. We present retrospective data on toxicity and local-regional-control of a patient cohort with LA-HNSCC treated with an IMRT-SIB-concept in comparison to normofractionated 3D-conformal radiotherapy (3D-RT) after a long-term follow-up.MethodsBetween 2012 and 2014, n=67 patients with HNSCC (stages III/IV without distant metastases) were treated with IMRT-SIB either definitive (single/total doses: 2.2/66Gy, 2.08/62.4Gy, 1.8/54Gy in 30 fractions) or in the postoperative setting (2.08/62.4Gy, 1.92/57.6Gy, 1.8/54Gy). These patients' clinical course was matched (for gender, primary, and treatment concept) as part of a matched-pair-analysis with patients treated before mid-2012 with normofractionated 3D-CRT (definitive: 2Gy/50Gy followed by a sequential boost up to 70Gy; postoperative: 2Gy/60-64Gy). Chemotherapy/immunotherapy was given concomitantly in both groups in the definitive situation (postoperative dependent on risk factors). Primary endpoints were acute and late toxicity; secondary endpoint was loco-regional-control (LRC).Results67 patients treated with IMRT-SIB (n = 20 definitive, n = 47 adjuvant) were matched with 67 patients treated with 3D-RT. There were minor imbalances between the groups concerning non-matching-variables like extracapsular extension (ECE) and chemotherapy in IMRT-SIB.Significantly less toxicity was found in favor of IMRT-SIB concerning dysphagia, radiation dermatitis, xerostomia, fibrosis, and lymphoedema. After a median follow-up of 63 months, median LRC was not reached (IMRT-SIB) vs. 69.5m (3D-RT) (p=0.63).ConclusionThis moderately hypofractionated IMRT-SIB-concept showed to be feasible with less toxicity compared to conventional 3D-RT in this long-term follow-up observation.

A phase I study of dose-escalated chemoradiation with accelerated intensity modulated radiotherapy in locally advanced head and neck cancer

2007 ◽  
Vol 85 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Teresa Guerrero Urbano ◽  
Catharine H. Clark ◽  
Vibeke N. Hansen ◽  
Elizabeth J. Adams ◽  
Roger A’Hern ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Phase I ◽  
Head And Neck ◽  
Neck Cancer ◽  
Phase I Study ◽  
Locally Advanced ◽  
Intensity Modulated Radiotherapy ◽  
Advanced Head ◽  
Intensity Modulated
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