Clinical outcome and prognostic factors after salvage surgery for isolated regional squamous cell carcinoma recurrences

Head & Neck ◽  
2014 ◽  
Vol 37 (11) ◽  
pp. 1612-1617 ◽  
Author(s):  
Eun-Jae Chung ◽  
Sang-Hyo Lee ◽  
So-Hye Baek ◽  
Woo-Jin Bae ◽  
Yong-Joon Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Clinical Outcome ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Salvage Surgery

Prognostic factors and outcomes for salvage surgery in patients with recurrent squamous cell carcinoma of the tongue

2013 ◽  
Vol 12 (1) ◽  
pp. e141-e148 ◽  
Author(s):  
Mitsuo Goto ◽  
Nobuhiro Hanai ◽  
Taijiro Ozawa ◽  
Hitoshi Hirakawa ◽  
Hidenori Suzuki ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Salvage Surgery ◽  
Recurrent Squamous Cell Carcinoma ◽  
Carcinoma Of The Tongue

scholarly journals The Current Role of Salvage Surgery in Recurrent Head and Neck Squamous Cell Carcinoma

Cancers ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 267 ◽  
Author(s):  
Marc Hamoir ◽  
Sandra Schmitz ◽  
Carlos Suarez ◽  
Primoz Strojan ◽  
Kate Hutcheson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Salvage Surgery ◽  
Primary Treatment ◽  
Oncologic Outcomes ◽  
Primary Tumors

Chemoradiotherapy has emerged as a gold standard in advanced squamous cell carcinoma of the head and neck (SCCHN). Because 50% of advanced stage patients relapse after nonsurgical primary treatment, the role of salvage surgery (SS) is critical because surgery is generally regarded as the best treatment option in patients with recurrent resectable SCCHN. Surgeons are increasingly confronted with considering operation among patients with significant effects of failed non-surgical primary treatment. Wide local excision to achieve clear margins must be balanced with the morbidity of the procedure, the functional consequences of organ mutilation, and the likelihood of success. Accurate selection of patients suitable for surgery is a major issue. It is essential to establish objective criteria based on functional and oncologic outcomes to select the best candidates for SS. The authors propose first to understand preoperative prognostic factors influencing survival. Predictive modeling based on preoperative information is now available to better select patients having a good chance to be successfully treated with surgery. Patients with a high comorbidity index, advanced oropharyngeal or hypopharyngeal primary tumors, and both local and regional recurrence have a very limited likelihood of success with salvage surgery and should be strongly considered for other treatments. Following SS, identifying patients with postoperative prognostic factors predicting high risk of recurrence is essential because those patients could benefit of adjuvant treatment or be included in clinical trials. Finally, defining HPV tumor status is needed in future studies including recurrent oropharyngeal SCC patients.

Sign in / Sign up

Export Citation Format

Share Document