Management of recurrent alveolar soft-part sarcoma of the tongue after external beam radiotherapy with iodine-125 seed brachytherapy

Head & Neck ◽  
2014 ◽  
Vol 36 (12) ◽  
pp. E125-E128 ◽  
Author(s):  
Na Meng ◽  
Xiaomeng Zhang ◽  
Anyan Liao ◽  
Suqing Tian ◽  
Weiqiang Ran ◽  
...  
Keyword(s):  
Soft Part ◽  
External Beam Radiotherapy ◽  
Alveolar Soft Part Sarcoma ◽  
External Beam ◽  
Iodine 125

scholarly journals Radiation necrosis after a combination of external beam radiotherapy and iodine-125 brachytherapy in gliomas

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Indrawati Hadi ◽  
Daniel Reitz ◽  
Raphael Bodensohn ◽  
Olarn Roengvoraphoj ◽  
Stefanie Lietke ◽  
...  
Keyword(s):  
Risk Factors ◽  
Radiation Necrosis ◽  
Irradiation Time ◽  
External Beam Radiotherapy ◽  
High Grade Glioma ◽  
Metabolic Imaging ◽  
Time Interval ◽  
Low Grade ◽  
External Beam ◽  
Iodine 125

Abstract Purpose Frequency and risk profile of radiation necrosis (RN) in patients with glioma undergoing either upfront stereotactic brachytherapy (SBT) and additional salvage external beam radiotherapy (EBRT) after tumor recurrence or vice versa remains unknown. Methods Patients with glioma treated with low-activity temporary iodine-125 SBT at the University of Munich between 1999 and 2016 who had either additional upfront or salvage EBRT were included. Biologically effective doses (BED) were calculated. RN was diagnosed using stereotactic biopsy and/or metabolic imaging. The rate of RN was estimated with the Kaplan Meier method. Risk factors were obtained from logistic regression models. Results Eighty-six patients (49 male, 37 female, median age 47 years) were included. 38 patients suffered from low-grade and 48 from high-grade glioma. Median follow-up was 15 months after second treatment. Fifty-eight patients received upfront EBRT (median total dose: 60 Gy), and 28 upfront SBT (median reference dose: 54 Gy, median dose rate: 10.0 cGy/h). Median time interval between treatments was 19 months. RN was diagnosed in 8/75 patients. The 1- and 2-year risk of RN was 5.1% and 11.7%, respectively. Tumor volume and irradiation time of SBT, number of implanted seeds, and salvage EBRT were risk factors for RN. Neither of the BED values nor the time interval between both treatments gained prognostic influence. Conclusion The combination of upfront EBRT and salvage SBT or vice versa is feasible for glioma patients. The risk of RN is mainly determined by the treatment volume but not by the interval between therapies.

scholarly journals Alveolar soft part sarcoma of extremity

2020 ◽  
Vol 8 (10) ◽  
pp. 3735
Author(s):  
Shilpa Kaushal ◽  
Muninder K. Negi
Keyword(s):  
Vascular Invasion ◽  
Soft Part ◽  
External Beam Radiotherapy ◽  
Distant Metastases ◽  
Surgical Excision ◽  
Alveolar Soft Part Sarcoma ◽  
High Likelihood ◽  
Histopathological Feature ◽  
History Of ◽  
Slow Growing

Alveolar soft-part sarcoma (ASPS) is an extremely rare connective tissue tumor, predominantly seen in adolescents and young adults, with a female preponderance. Alveolar soft-part sarcoma (ASPS) is a slow growing tumor, but with high likelihood of metastasis, leading to high mortality. A classical histopathological feature of an alveolar pattern from the biopsy of the lesion favors the diagnosis. We report a case of 14 years old male patient who presented with a history of single painless swelling over thigh for which surgical excision was done. Histopathology was suggestive of Alveolar soft-part sarcoma (ASPS). There was no evidence of distant metastases. He was treated with external beam radiotherapy in view of vascular invasion.

scholarly journals Cryoablation Combined with Iodine-125 Implantation in the Treatment of Cardiac Metastasis from Alveolar Soft Part Sarcoma: A Case Report

2016 ◽  
Vol 1 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Lizhi Niu ◽  
Xiaomei Luo ◽  
Jianying Zeng ◽  
Xiaofeng Kong ◽  
Gang Fang ◽  
...  
Keyword(s):  
Palliative Treatment ◽  
Ultrasound Guidance ◽  
Soft Part ◽  
Imaging Techniques ◽  
Alveolar Soft Part Sarcoma ◽  
Uneventful Recovery ◽  
Cardiac Metastasis ◽  
Seed Implantation ◽  
History Of ◽  
Iodine 125

Objectives: A 36-year-old Asian man was referred to our hospital with cardiac metastasis. He had a history of alveolar soft part sarcoma and initially underwent resection in 2005. Methods: After exposing the tumor by thoracotomy, cryoablation was performed under ultrasound guidance. This treatment was combined with iodine-125 seed implantation to treat the cardiac metastasis. Results: The patient had an uneventful recovery, and his cardiac function shows no obvious abnormalities. Imaging techniques suggest that cardiac metastasis was well controlled, and the patient is still alive 12 months after treatment. Conclusions: Tumor cryoablation, combined with iodine seed implantations, may be regarded as a means of palliative treatment.

Sign in / Sign up

Export Citation Format

Share Document