Definitive radiotherapy for cervical esophageal cancer

Head & Neck ◽  
2014 ◽  
Vol 37 (2) ◽  
pp. 151-155 ◽  
Author(s):  
Caineng Cao ◽  
Jingwei Luo ◽  
Li Gao ◽  
Guozhen Xu ◽  
Junlin Yi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cervical Esophageal Cancer ◽  
Definitive Radiotherapy

scholarly journals Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 21852-21860 ◽  
Author(s):  
Lina Zhao ◽  
Yongchun Zhou ◽  
Yunfeng Mu ◽  
Guangjin Chai ◽  
Feng Xiao ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Clinical Outcomes ◽  
Cervical Esophageal Cancer ◽  
Patterns Of Failure ◽  
Definitive Radiotherapy

scholarly journals Chondroradionecrosis of the trachea after definitive radiotherapy for cervical esophageal cancer: A case report

2021 ◽  
Vol 9 (9) ◽  
Author(s):  
Jina Kim ◽  
Sun Il Kim ◽  
Chang Geol Lee ◽  
Jee Suk Chang ◽  
Tae Hyung Kim
Keyword(s):  
Esophageal Cancer ◽  
Case Report ◽  
Cervical Esophageal Cancer ◽  
Definitive Radiotherapy

scholarly journals Outcomes and prognostic factors for patients with cervical esophageal cancer undergoing definitive radiotherapy or chemoradiotherapy

2019 ◽  
Author(s):  
Xin-xin Du ◽  
Rong Yu ◽  
Zhen-fei Wang ◽  
De-cheng Du ◽  
Qiao-yun Liu ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Clinical Stage ◽  
Independent Prognostic Factor ◽  
Tumor Control ◽  
Cervical Esophageal Cancer ◽  
Free Survival ◽  
Definitive Radiotherapy

Cervical esophageal cancer (CEC) is uncommon, accounting for less than 5% of all esophageal cancers. The management of CEC is controversial. This study investigated treatment outcomes and prognostic factors of survival in CEC patients undergoing definitive radiotherapy or concurrent chemoradiotherapy (CCRT). Ninety-one CEC patients were treated by intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3DCRT) between July 2007 and September 2017. The mean prescription dose was 64 Gy (range 54-70 Gy) delivered as 1.8-2.2 Gy per fraction per day, 5 days a week. Out of 91 patients, 34 received concurrent cisplatin-based chemotherapy (CT) including 18 patients who also received neoadjuvant CT. Overall survival (OS), locoregional failure-free survival (LRFFS), and progression-free survival (PFS) were estimated by the Kaplan–Meier method. Prognostic factors of survival were determined in univariate (log-rank test) and multivariate (Cox proportional hazard model) analysis. Treatment-related toxicity was also assessed. Median follow-up time for all patients was 19 months. Two-year OS, LRFFS and PFS of all patients were 58.2%, 52.5% and 48.1%, respectively. Clinical stage was an independent prognostic factor for OS (HR = 2.35, 95% CI: 1.03-5.37, p = 0.042), LRFFS (HR = 3.84, 95% CI: 1.38-10.69, p = 0.011), and PFS (HR = 2.68, 95% CI: 1.11-6.45, p = 0.028). Hoarseness was an independent prognostic factor for OS (HR = 2.10, 95% CI: 1.05-4.19, p = 0.036). CCRT was independently associated with better LRFFS (HR = 0.33, 95% CI: 0.14-0.79, p = 0.012). 3DCRT and IMRT with concurrent CT is well-tolerated and may improve local tumor control in CEC patients. Advanced clinical stage and hoarseness are adverse prognostic factors for OS, LRFFS, and PFS in CEC.

The treatment results of definitive radiotherapy for cervical esophageal cancer: a single-institution experience

Esophagus ◽  
2017 ◽  
Vol 14 (3) ◽  
pp. 254-261 ◽  
Author(s):  
Yu Ohkubo ◽  
Yoshihiro Saito ◽  
Shigehiro Kudo ◽  
Hiroki Ushijima ◽  
Miwako Arima ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Single Institution ◽  
Treatment Results ◽  
Cervical Esophageal Cancer ◽  
Definitive Radiotherapy

Past and Current Trends in Treatment for Cervical Esophageal Cancer, Based on 32 Years of Experience

2006 ◽  
Vol 57 (2) ◽  
pp. 115-119
Author(s):  
H. Udagawa ◽  
K. Tsutsumi ◽  
Y. Kinoshita ◽  
M. Ueno ◽  
S. Mine ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Years Of Experience ◽  
Cervical Esophageal Cancer ◽  
Current Trends

scholarly journals Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer: a multi-center study from China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiao Chang ◽  
Wei Deng ◽  
Xin Wang ◽  
Zongmei Zhou ◽  
Jun Yang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Gross Tumor Volume ◽  
Tumor Volume ◽  
Interobserver Variability ◽  
Target Volume ◽  
Thoracic Esophageal Cancer ◽  
Target Volume Delineation ◽  
Cancer Centers ◽  
Definitive Radiotherapy ◽  
Volume Delineation

Abstract Purpose To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies. Methods Sixteen cancer centers throughout China participated in this study. In Phase 1, three suitable cases with upper, middle, and lower TEC were chosen, and participants were asked to contour a group of gross tumor volume (GTV-T), nodal gross tumor volume (GTV-N) and clinical target volume (CTV) for each case based on their routine experience. In Phase 2, the same clinicians were instructed to follow a contouring protocol to re-contour another group of target volume. The variation of the target volume was analyzed and quantified using dice similarity coefficient (DSC). Results Sixteen clinicians provided routine volumes, whereas ten provided both routine and protocol volumes for each case. The IOV of routine GTV-N was the most striking in all cases, with the smallest DSC of 0.37 (95% CI 0.32–0.42), followed by CTV, whereas GTV-T showed high consistency. After following the protocol, the smallest DSC of GTV-N was improved to 0.64 (95% CI 0.45–0.83, P = 0.005) but the DSC of GTV-T and CTV remained constant in most cases. Conclusion Variability in target volume delineation was observed, but it could be significantly reduced and controlled using mandatory interventions.

PS02.146: LARYNX-PRESERVING SURGERY FOR CERVICAL ESOPHAGEAL CANCER USING INTRAOPERATIVE ENDOSCOPIC SUBMUCOSAL DISSECTION: A CASE REPORT

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 162-162
Author(s):  
Yoshiki Taniguchi ◽  
Koji Tanaka ◽  
Yasuhiro Miyazaki ◽  
Tomoki Makino ◽  
Tsuyoshi Takahashi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Invasion ◽  
Pathological Examination ◽  
Submucosal Layer ◽  
Cervical Esophageal Cancer ◽  
Submucosal Dissection

Abstract Background We sometimes experience cases of cervical esophageal cancer which requires laryngectomy due to spread of cancer to larynx. We report a case of esophageal cancer resection with preservation of larynx using intraoperative endoscopic submucosal dissection. Methods The patient was a 59-year-old woman who had dysphagia. She had received total gastrectomy with Roux-en-Y reconstruction for gastric cancer in 2001, chemoradiation (61.2Gy) for esophageal cancer in 2008. Argon plasma coagulation (APC) was performed for the carcinoma in situ of cervical esophagus in 2016. This time superficial 0-IIc tumor was observed at the same site of the scar of APC, and a biopsy revealed squamous cell carcinoma. An endoscopic findings revealed two 0-IIc lesions at distance of 18–22 cm, and 32–34 cm from the incisors, and biopsy resulted in a diagnosis of squamous cell carcinoma. Since tumor was close to the esophageal orifice, the tumor invasion to the larynx was suspected. On the other hand, there were no obvious findings of the submucosal layer invasion, and the both tumor were thought to be limited to the epithelium or lamina propria mucosae (EP/LPM). We performed mediastinoscopic and thoracoscopic transhiatal esophagectomy, subcutaneous ileocolic reconstruction. Results After confirming the tumor invasion to the esophageal orifice by chromoendoscopy with 1% Lugol's iodine solution, we dissected the whole circumference of esophagus in submucosal layer just above the tumor by ESD, put an incision outside of esophageal wall, and resected the esophagus. We preserved short length of muscle layer and performed reconstruction with hypopharynx-ileum anastomosis. Pathological examination revealed squamous cell carcinoma, pT1a-EP, ly0, v0, pPM0, pDM0, pIM0, and curative resection was performed. The postoperative course was uneventful. Conclusion There were no reports of successful larynx-preserving surgery for cervical esophageal cancer using intraoperative ESD. When the tumor was limited in the mucosa, esophagectomy with intraoperative ESD may enable larynx preservation even if the tumor invaded to the esophageal orifice. Disclosure All authors have declared no conflicts of interest.

Sign in / Sign up

Export Citation Format

Share Document