scholarly journals Depth of invasion, tumor budding, and worst pattern of invasion: Prognostic indicators in early‐stage oral tongue cancer

Head & Neck ◽  
2013 ◽  
Vol 36 (6) ◽  
pp. 811-818 ◽  
Author(s):  
Alhadi Almangush ◽  
Ibrahim O. Bello ◽  
Harri Keski–Säntti ◽  
Laura K. Mäkinen ◽  
Joonas H. Kauppila ◽  
...  
Keyword(s):  
Tongue Cancer ◽  
Early Stage ◽  
Tumor Budding ◽  
Prognostic Indicators ◽  
Depth Of Invasion ◽  
Oral Tongue ◽  
Oral Tongue Cancer ◽  
Pattern Of Invasion ◽  
Worst Pattern Of Invasion

scholarly journals Improving Risk Stratification of Early Oral Tongue Cancer with TNM-Immune (TNM-I) Staging System

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3235
Author(s):  
Alhadi Almangush ◽  
Ibrahim O. Bello ◽  
Ilkka Heikkinen ◽  
Jaana Hagström ◽  
Caj Haglund ◽  
...  
Keyword(s):  
Overall Survival ◽  
Tongue Cancer ◽  
Early Stage ◽  
Disease Free Survival ◽  
Tumor Infiltrating Lymphocytes ◽  
Staging System ◽  
Oral Tongue ◽  
Oral Tongue Cancer ◽  
Important Player ◽  
Infiltrating Lymphocytes

Although patients with early-stage oral tongue squamous cell carcinoma (OTSCC) show better survival than those with advanced disease, there is still a number of early-stage cases who will suffer from recurrence, cancer-related mortality and worse overall survival. Incorporation of an immune descriptive factor in the staging system can aid in improving risk assessment of early OTSCC. A total of 290 cases of early-stage OTSCC re-classified according to the American Joint Committee on Cancer (AJCC 8) staging were included in this study. Scores of tumor-infiltrating lymphocytes (TILs) were divided as low or high and incorporated in TNM AJCC 8 to form our proposed TNM-Immune system. Using AJCC 8, there were no significant differences in survival between T1 and T2 tumors (p > 0.05). Our proposed TNM-Immune staging system allowed for significant discrimination in risk between tumors of T1N0M0-Immune vs. T2N0M0-Immune. The latter associated with a worse overall survival with hazard ratio (HR) of 2.87 (95% CI 1.92–4.28; p < 0.001); HR of 2.41 (95% CI 1.26–4.60; p = 0.008) for disease-specific survival; and HR of 1.97 (95% CI 1.13–3.43; p = 0.017) for disease-free survival. The TNM-Immune staging system showed a powerful ability to identify cases with worse survival. The immune response is an important player which can be assessed by evaluating TILs, and it can be implemented in the staging criteria of early OTSCC. TNM-Immune staging forms a step towards a more personalized classification of early OTSCC.

A novel tumor: Specimen index for assessing adequacy of resection in early stage oral tongue cancer

Oral Oncology ◽  
2014 ◽  
Vol 50 (3) ◽  
pp. 213-220 ◽  
Author(s):  
Pablo H. Montero ◽  
Frank L. Palmer ◽  
Andrew G. Shuman ◽  
Purvi D. Patel ◽  
Jay O. Boyle ◽  
...  
Keyword(s):  
Tongue Cancer ◽  
Early Stage ◽  
Oral Tongue ◽  
Tumor Specimen ◽  
Oral Tongue Cancer

scholarly journals Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies

2017 ◽  
Vol 472 (2) ◽  
pp. 231-236 ◽  
Author(s):  
Alhadi Almangush ◽  
Ilmo Leivo ◽  
Maria Siponen ◽  
Elias Sundquist ◽  
Rayan Mroueh ◽  
...  
Keyword(s):  
Tongue Cancer ◽  
Depth Of Invasion ◽  
Oral Tongue ◽  
Oral Tongue Cancer

A simple novel prognostic model for early stage oral tongue cancer

2015 ◽  
Vol 44 (2) ◽  
pp. 143-150 ◽  
Author(s):  
A. Almangush ◽  
R.D. Coletta ◽  
I.O. Bello ◽  
C. Bitu ◽  
H. Keski-Säntti ◽  
...  
Keyword(s):  
Prognostic Model ◽  
Tongue Cancer ◽  
Early Stage ◽  
Oral Tongue ◽  
Oral Tongue Cancer

SU-E-T-887: Cyberknife Treatment for Early Stage Oral Tongue Cancer - Feasibility Study

2011 ◽  
Vol 38 (6Part24) ◽  
pp. 3695-3696
Author(s):  
J Fan ◽  
E Fourka ◽  
S Hayes ◽  
L Jin ◽  
L Wang ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Tongue Cancer ◽  
Early Stage ◽  
Oral Tongue ◽  
Oral Tongue Cancer

Controversies in relation to neck management in N0 early oral tongue cancer

2019 ◽  
Vol 49 (4) ◽  
pp. 297-305 ◽  
Author(s):  
Nobuhiro Hanai ◽  
Takahiro Asakage ◽  
Naomi Kiyota ◽  
Akihiro Homma ◽  
Ryuichi Hayashi
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Tongue Cancer ◽  
Early Stage ◽  
Oral Tongue ◽  
Invasive Treatment ◽  
Node Metastasis ◽  
Oral Tongue Cancer ◽  
Prophylactic Neck Dissection ◽  
Occult Lymph Node Metastasis

Abstract The standard local treatment for early-stage tongue cancer with no clinical lymph node metastases is partial glossectomy. The frequency of occult lymph node metastasis is ~20–30%. Thus, whether prophylactic neck dissection with glossectomy or glossectomy alone should be performed has been a controversial issue since the 1980s. Both treatments have advantages and disadvantages; however, especially in cases involving prophylactic neck dissection, surgical invasion and complications including the cosmetic disadvantage caused by neck skin incision, accessory nerve paralysis or facial nerve (mandibular marginal branch) paralysis, stiffness of the shoulder or neck and a feeling of neck tightness have been considered issues that could be solved by providing less-invasive treatment to the 70–80% of patients without occult lymph node metastasis. A more accurate preoperative diagnosis and strict follow-up are required to provide minimally invasive treatment while ensuring the therapeutic effect. It is also necessary to narrow down the target based on the risk–benefit balance. The depth of invasion should be considered in cases involving oral cavity malignancies. This was also taken into account in recent revisions of eighth edition of the TNM Classification of Malignant Tumors and it is an important factor for N0 neck management. This review article summarizes previous and recent reports on neck management, focusing on the risk–benefit and future perspectives of the diagnosis and treatment of early-stage oral tongue cancer. This effort is an attempt to establish treatment from the patient’s point of view, with the patient’s quality of life taken into account.

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