scholarly journals Effect of erlotinib on epidermal growth factor receptor and downstream signaling in oral cavity squamous cell carcinoma

Head & Neck ◽  
2012 ◽  
Vol 35 (9) ◽  
pp. 1323-1330 ◽  
Author(s):  
Christina I. Tsien ◽  
Mukesh K. Nyati ◽  
Aarif Ahsan ◽  
Susmita G. Ramanand ◽  
Douglas B. Chepeha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Downstream Signaling ◽  
Epidermal Growth

scholarly journals Occurrence of Epidermal Growth Factor Receptor Expression in Squamous Cell Carcinoma of Oral Cavity and Adjacent Sites: A Retrospective Observational Study

2021 ◽  
Vol 42 (03) ◽  
pp. 255-260
Author(s):  
Senjuti Dasgupta ◽  
Sudipta Chakrabarti ◽  
Asit R. Deb
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Egfr Expression ◽  
Epidermal Growth

Abstract Introduction Oral cavity squamous cell carcinomas (OCSCCs) are one of the most common malignancies encountered. They have diverse clinicopathologic profiles. Epidermal growth factor receptor (EGFR) is an important marker of OCSCC for diagnosis, prognosis, and therapy. Objective The study aimed to evaluate the distribution of clinicopathological parameters in cases of squamous cell carcinoma (SCC) of the oral cavity and adjacent sites and their EGFR expression. An attempt was made to correlate EGFR scores with different parameters. Materials and Methods An observational retrospective study was undertaken for 1 year. Patients with histologically proven SCC of the oral cavity and adjacent sites were included. Clinicopathologic and immunohistochemical features of each case were analyzed. Results A total of 59 cases of SCC were included of which 41 (69%) were males. The mean age of the patients was 56.4 ± 10.3 years. The most common location of the tumors was oral cavity (31, 53%) followed by larynx (10, 16%). Most cases were moderately differentiated tumors (31, 53%). Immunohistochemical analysis showed low EGFR score in 7 (11.9%) cases, intermediate in 6 (10.1%), and high in 46 (78%) cases. Association between gender of patients and EGFR score was statistically significant (p = 0.000159). Most lesions of the oral cavity (31 cases, 53%) had a high EGFR score (23 cases, 74.2%). A statistically significant correlation was found between tumor grade and EGFR score (p = 0.03338). Conclusion This study from eastern region of India reveals unique characteristics of EGFR expression in SCC of the oral cavity and adjacent sites.

Epidermal growth factor receptor as an adverse survival predictor in squamous cell carcinoma of the penis

2017 ◽  
Vol 61 ◽  
pp. 97-104 ◽  
Author(s):  
Alice Muglia Thomaz da Silva Amancio ◽  
Isabela Werneck da Cunha ◽  
José Ivanildo Neves ◽  
Josiane da Silva Quetz ◽  
Dirce Maria Carraro ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Survival Predictor

scholarly journals β-Catenin/CBP inhibition alters epidermal growth factor receptor fucosylation status in oral squamous cell carcinoma

2020 ◽  
Vol 16 (3) ◽  
pp. 195-209 ◽  
Author(s):  
Kevin Brown Chandler ◽  
Khalid A. Alamoud ◽  
Vanessa L. Stahl ◽  
Bach-Cuc Nguyen ◽  
Vinay K. Kartha ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Oral Cancer ◽  
Epidermal Growth Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Growth Factor Receptor ◽  
Epidermal Growth

Genomic and structural analyses reveal that β-catenin/CBP signaling represses epidermal growth factor receptor (EGFR) N-glycan antennary fucosylation in oral cancer.

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