Increased radioresistance via G12S K-Ras by compensatory upregulation of MAPK and PI3K pathways in epithelial cancer

Head & Neck ◽  
2012 ◽  
Vol 35 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Annette Affolter ◽  
Martynas Drigotas ◽  
Kai Fruth ◽  
Irene Schmidtmann ◽  
Christoph Brochhausen ◽  
...  
Keyword(s):  
Epithelial Cancer ◽  
Increased Radioresistance

scholarly journals MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Diala Kantar ◽  
Emilie Bousquet Mur ◽  
Maicol Mancini ◽  
Vera Slaninova ◽  
Yezza Ben Salah ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cancer Progression ◽  
Hippo Pathway ◽  
Intercellular Junctions ◽  
Cell Polarization ◽  
Actin Binding ◽  
Breast Cancers ◽  
Epithelial Cancer ◽  
Breast Tumorigenesis ◽  
Stress Pathway

AbstractAlterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression, including breast cancers (BCa). We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa, and promotes tumorigenesis. E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased stiffness. These alterations are associated with low YAP activity, the terminal Hippo-pathway effector, but with an elevated ROCK and p38 Stress Activated Protein Kinase activities. Blocking ROCK prevented p38 activation, suggesting that MAGI1 limits p38 activity in part through releasing actin strength. Importantly, the increased tumorigenicity of MAGI1 deficient cells is rescued in the absence of AMOTL2 or after inhibition of p38, demonstrating that MAGI1 acts as a tumor-suppressor in luminal BCa by inhibiting an AMOTL2/p38 stress pathway.

Taxol (T): An active new drug in ovarian epithelial cancer (OVCA)

1989 ◽  
Vol 32 (1) ◽  
pp. 111 ◽  
Author(s):  
W.P. McGuire ◽  
E.K. Rowinsky ◽  
N.B. Rosenshein ◽  
F.C. Grumbine ◽  
M.B. Dillon ◽  
...  
Keyword(s):  
Epithelial Cancer ◽  
New Drug ◽  
Ovarian Epithelial Cancer

Detection of a set of peptide vaccine candidates for use in HLA-A31+ epithelial cancer patients

2004 ◽  
Author(s):  
Hiroko Takedatsu ◽  
Shigeki Shichijo ◽  
Kouichi Azuma ◽  
Hidetoshi Takedatsu ◽  
Michio Sata ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Peptide Vaccine ◽  
Epithelial Cancer ◽  
Vaccine Candidates

Adjuvant whole abdominal radiotherapy in epithelial cancer of the ovary

2002 ◽  
Vol 53 (2) ◽  
pp. 360-365 ◽  
Author(s):  
Rodrigo Hepp ◽  
Mario R Baeza ◽  
Patricio Olfos ◽  
Eugenio Suarez
Keyword(s):  
Epithelial Cancer ◽  
Abdominal Radiotherapy

scholarly journals Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations

2012 ◽  
Vol 41 (5) ◽  
pp. 1751-1761 ◽  
Author(s):  
FABRIZIO GALIMBERTI ◽  
ALEXANDER M. BUSCH ◽  
FADZAI CHINYENGETERE ◽  
TIAN MA ◽  
DAVID SEKULA ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Epithelial Cancer ◽  
Patched 1
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