Significance of molecular markers in survival prediction of oral squamous cell carcinoma

Head & Neck ◽  
2011 ◽  
Vol 34 (7) ◽  
pp. 929-936 ◽  
Author(s):  
Ki-Yeol Kim ◽  
ShengJin Li ◽  
Jeong-Dan Cha ◽  
Xianglan Zhang ◽  
In-Ho Cha
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Prediction

Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis

Head & Neck ◽  
2009 ◽  
Vol 31 (12) ◽  
pp. 1544-1556 ◽  
Author(s):  
Neelam G. Shah ◽  
Trupti I. Trivedi ◽  
Rajen A. Tankshali ◽  
Jignesh V. Goswami ◽  
Dhaval H. Jetly ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Multivariate Analysis ◽  
Molecular Markers ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Significance

scholarly journals p53 & Cyclin D1 expression in surgically resected clear margins of oral squamous cell carcinoma

2021 ◽  
Vol 20 ◽  
pp. e210298
Author(s):  
Snega Thamilselvan ◽  
Archana Santhanam ◽  
Herald J. Sherlin ◽  
Gifrina Jayaraj ◽  
K. R. Don
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Surgical Margins ◽  
Staining Procedure ◽  
P53 Expression ◽  
Mild Dysplasia

Oral squamous cell carcinoma (OSCC) is one of the most well-known malignancies that affect the human population worldwide. The early diagnosis and early intervention of OSCC help improve the survival rate of the patients. The tumour free surgical margins are a positive prognostic factor for recurrence-free survival. The molecular markers can be used to detect the tumour free surgical margins. Aim: The aim of the study is to evaluate the expression of p53 & Cyclin D1 marker in resected surgical apparently clear margins and to correlate the p53 & Cyclin D1 expression with clinicopathological characteristics and patient outcome. Methods: The study population included retrospective cases of OSCC with apparently clear margins (2017-18) n=10 and Clinicopathological variables relevant to survival analysis were recorded. Finally, two margins were selected from each case, a total of 20 margins were included in this study. Paraffin-embedded wax blocks retrieved and tissue sections were made. Expression of cyclin D1 and p 53 was assessed by the immunohistochemical staining procedure Results: Positive expressions Cyclin D1 in 40% of mild dysplasia margins and 60% in clearance adequate margins were present. p53 expression was seen in 16% of mild dysplasia margins and 84% in clearance adequate margins. The expression of p53 and Cyclin D1 molecular markers are noted in the basal & parabasal layer of epithelium. Conclusion: Molecular markers could play a more reliable method for the assessment of dysplasia at the margins.

scholarly journals Understanding molecular markers in recurrent oral squamous cell carcinoma treated with chemoradiation

Heliyon ◽  
2016 ◽  
Vol 2 (12) ◽  
pp. e00206 ◽  
Author(s):  
Seema Gupta ◽  
Vandana Singh Kushwaha ◽  
Sandeep Verma ◽  
Huma Khan ◽  
M.L.B. Bhatt ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell
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