Surgical management of radiation-induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: Report of 14 cases

Head & Neck ◽  
2010 ◽  
Vol 33 (10) ◽  
pp. 1493-1500 ◽  
Author(s):  
Yong-gao Mou ◽  
Ke Sai ◽  
Zhen-ning Wang ◽  
Xiang-heng Zhang ◽  
Yan-chun Lu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Surgical Management ◽  
Temporal Lobe ◽  
Temporal Lobe Necrosis ◽  
Radiation Induced

scholarly journals Temporal Lobe Necrosis Following Radiotherapy in Nasopharyngeal Carcinoma: New Insight Into the Management

2021 ◽  
Vol 10 ◽  
Author(s):  
Xin Zhou ◽  
Peiyao Liu ◽  
Xiaoshen Wang
Keyword(s):  
Radiation Therapy ◽  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Intensity Modulated Radiation Therapy ◽  
Therapeutic Interventions ◽  
Humanized Monoclonal Antibody ◽  
Temporal Lobe Necrosis ◽  
Radiation Induced ◽  
Endothelial Growth Factor

Cerebral radiation necrosis (CRN) is one of the most prominent sequelae following radiation therapy for nasopharyngeal carcinoma (NPC), which might have devastating effects on patients’ quality of life (QOL). Advances in histopathology and neuro-radiology have shed light on the management of CRN more comprehensively, yet effective therapeutic interventions are still lacking. CRN was once regarded as progressive and irreversible, however, in the past 20 years, with the application of intensity-modulated radiation therapy (IMRT), both the incidence and severity of CRN have declined. In addition, newly developed medical agents including bevacizumab-a humanized monoclonal antibody against vascular endothelial growth factor (VEGF), nerve growth factor (NGF), monosialotetrahexosylganglioside (GM1), etc., have shown great potency in successfully reversing radiation-induced CRN. As temporal lobes are most frequently compromised in NPC patients, this review will summarize the state-of-the-art progress regarding the incidence, pathophysiology, prevention, treatment, and prognosis of temporal lobe necrosis (TLN) after IMRT in NPC.

scholarly journals Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management

2011 ◽  
Vol 6 (1) ◽  
pp. 128 ◽  
Author(s):  
Jing Chen ◽  
Meera Dassarath ◽  
Zhongyuan Yin ◽  
Hongli Liu ◽  
Kunyu Yang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Temporal Lobe Necrosis ◽  
Radiation Induced

Surgical techniques in radiation induced temporal lobe necrosis in nasopharyngeal carcinoma patients

2016 ◽  
Vol 50 (3) ◽  
pp. 172-179 ◽  
Author(s):  
Gobran Taha Ahmed Alfotih ◽  
Mei Guang Zheng ◽  
Wang Qing Cai ◽  
Xin Ke Xu ◽  
Zhen Hu ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Temporal Lobe ◽  
Surgical Techniques ◽  
Temporal Lobe Necrosis ◽  
Radiation Induced

Clinical diagnosis of late temporal lobe necrosis following radiation therapy for nasopharyngeal carcinoma

Cancer ◽  
1988 ◽  
Vol 61 (8) ◽  
pp. 1535-1542 ◽  
Author(s):  
Anne W. M. Lee ◽  
John H. C. Ho ◽  
Vincent K. C. Tse ◽  
Y. F. Poon ◽  
Gordon K. H. Au ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Nasopharyngeal Carcinoma ◽  
Clinical Diagnosis ◽  
Temporal Lobe ◽  
Temporal Lobe Necrosis
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