scholarly journals Immunocompetent murine model of cancer cachexia for head and neck squamous cell carcinoma

Head & Neck ◽  
2008 ◽  
Vol 30 (3) ◽  
pp. 320-326 ◽  
Author(s):  
Trinitia Cannon ◽  
Carol Shores ◽  
Xiaoying Yin ◽  
Jason Dahlman ◽  
Denis Guttridge ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Murine Model ◽  
Cancer Cachexia ◽  
Neck Squamous Cell Carcinoma

scholarly journals Association Between Cancer Cachexia and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma Who Received Chemoradiotherapy

2021 ◽  
Author(s):  
Naomi Hayashi ◽  
Yasuyoshi Sato ◽  
Yu Fujiwara ◽  
Naoki Fukuda ◽  
Xiaofei Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factors ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cancer Cachexia ◽  
Neck Squamous Cell Carcinoma ◽  
Adjuvant Chemoradiotherapy ◽  
Adjuvant Setting ◽  
Definitive Chemoradiotherapy

Abstract Objectives: This retrospective observational study is conducted to evaluate the association between cancer cachexia and prognosis in head and neck cancer patients treated with chemoradiotherapy using skeletal muscle mass index at the level of the third lumbar vertebra with computed tomography.Methods: Two hundred forty-two patients were enrolled and categorized into the following four groups based on cancer cachexia criteria and treatment setting: definitive chemoradiotherapy with cachexia, definitive chemoradiotherapy without cachexia, adjuvant chemoradiotherapy with cachexia, and adjuvant chemoradiotherapy without cachexia. Progression-free survival (PFS) and overall survival (OS) between cachexia and non-cachexia groups were compared by treatment setting using the long-rank test. Prognostic factors were evaluated using the Cox proportional hazards model.Results: Fifty patients were diagnosed with cancer cachexia (20.7%). In the definitive setting, both PFS and OS were significantly shorter in the cachexia group (median PFS, 15.5 months vs. not reached, p < 0.01; median OS, 48.4 months vs. not reached. p < 0.01). Conversely, there was no significant difference between the two groups in the adjuvant setting. UICC Stage IV, base of albumin of <4, and cachexia were significant poor prognostic factors in the definitive setting. However, no prognostic factors were detected in the adjuvant setting.Conclusion: Cancer cachexia was negatively related with prognosis in patients with head and neck squamous cell carcinoma who received definitive chemoradiotherapy. Nutritional intervention during chemoradiotherapy may improve survival in these patients. Further research is warranted.

scholarly journals A Cytokine-Delivering Polymer Is Effective in Reducing Tumor Burden in a Head and Neck Squamous Cell Carcinoma Murine Model

2014 ◽  
Vol 151 (3) ◽  
pp. 447-453 ◽  
Author(s):  
Yuan Lin ◽  
Jie Luo ◽  
Weichao Eric Zhu ◽  
Minu Srivastava ◽  
Dorthe Schaue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Murine Model ◽  
Tumor Burden ◽  
Neck Squamous Cell Carcinoma
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