Effects of artemisinin and its derivatives on growth inhibition and apoptosis of oral cancer cells

Head & Neck ◽  
2007 ◽  
Vol 29 (4) ◽  
pp. 335-340 ◽  
Author(s):  
Woong Nam ◽  
Jungae Tak ◽  
Ju-Kyoung Ryu ◽  
Mankil Jung ◽  
Jong-In Yook ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Oral Cancer Cells

scholarly journals Erratum to “Isocudraxanthone K Induces Growth Inhibition and Apoptosis in Oral Cancer Cells via Hypoxia Inducible Factor-1α”

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Mee-Ran Shin ◽  
Hwa-Jeong Lee ◽  
Soo-Kyung Kang ◽  
Q-Schick Auh ◽  
Young-Man Lee ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1Α ◽  
Oral Cancer Cells

scholarly journals Soft Coral-Derived Dihydrosinularin Exhibits Antiproliferative Effects Associated with Apoptosis and DNA Damage in Oral Cancer Cells

2021 ◽  
Vol 14 (10) ◽  
pp. 994
Author(s):  
Kun-Han Yang ◽  
Yu-Sheng Lin ◽  
Sheng-Chieh Wang ◽  
Min-Yu Lee ◽  
Jen-Yang Tang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Cell Growth ◽  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Soft Coral ◽  
Oral Cancer Cells

Dihydrosinularin (DHS) is an analog of soft coral-derived sinularin; however, the anticancer effects and mechanisms of DHS have seldom been reported. This investigation examined the antiproliferation ability and mechanisms of DHS on oral cancer cells. In a cell viability assay, DHS showed growth inhibition against several types of oral cancer cell lines (Ca9-22, SCC-9, OECM-1, CAL 27, OC-2, and HSC-3) with no cytotoxic side effects on non-malignant oral cells (HGF-1). Ca9-22 and SCC-9 cell lines showing high susceptibility to DHS were selected to explore the antiproliferation mechanisms of DHS. DHS also causes apoptosis as detected by annexin V, pancaspase, and caspase 3 activation. DHS induces oxidative stress, leading to the generation of reactive oxygen species (ROS)/mitochondrial superoxide (MitoSOX) and mitochondrial membrane potential (MitoMP) depletion. DHS also induced DNA damage by probing γH2AX phosphorylation. Pretreatment with the ROS scavenger N-acetylcysteine (NAC) can partly counter these DHS-induced changes. We report that the marine natural product DHS can inhibit the cell growth of oral cancer cells. Exploring the mechanisms of this cancer cell growth inhibition, we demonstrate the prominent role DHS plays in oxidative stress.

Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway

2010 ◽  
Vol 20 (20) ◽  
pp. 6145-6148 ◽  
Author(s):  
Wan-Chi Tsai ◽  
Yerra Koteswara Rao ◽  
Shih-Shen Lin ◽  
Ming-Yung Chou ◽  
Yi-Ting Shen ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Specific Growth ◽  
Apoptotic Pathway ◽  
Mitochondrial Apoptotic Pathway ◽  
Oral Cancer Cells

scholarly journals Ethyl acetate extracts of Nepenthes ventricosa x sibuyanensis leaves cause growth inhibition against oral cancer cells via oxidative stress

2019 ◽  
Vol Volume 12 ◽  
pp. 5227-5239
Author(s):  
Jen-Yang Tang ◽  
Tzu-Jung Yu ◽  
Li-Ching Lin ◽  
Sheng-Yao Peng ◽  
Chun-Lin Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oral Cancer ◽  
Growth Inhibition ◽  
Ethyl Acetate ◽  
Cancer Cells ◽  
Oral Cancer Cells ◽  
Ethyl Acetate Extracts

scholarly journals Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-κB, and SIRT1 Signaling Pathway

Planta Medica ◽  
2013 ◽  
Vol 79 (14) ◽  
pp. E3-E3
Author(s):  
Hwa-Jeong Lee ◽  
Q-Schick Auh ◽  
Young-Man Lee ◽  
Soo-Kyung Kang ◽  
Seok-Woo Chang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Oral Cancer Cells

Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-κB, and SIRT1 Signaling Pathway

Planta Medica ◽  
2013 ◽  
Vol 79 (14) ◽  
pp. 1298-1306 ◽  
Author(s):  
Hwa-Jeong Lee ◽  
Q-Schick Auh ◽  
Young-Man Lee ◽  
Soo-Kyung Kang ◽  
Seok-Woo Chang ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Oral Cancer Cells

scholarly journals Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells

2016 ◽  
Vol 41 (3) ◽  
pp. 105-111 ◽  
Author(s):  
Sung-Su Yang ◽  
◽  
Su-Gwan Kim ◽  
Byung-Sun Park ◽  
Dae-San Go ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Cell Growth Inhibition ◽  
Oral Cancer Cells ◽  
Β Carotene
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