Akt, protein kinase C, and mitogen-activated protein kinase phosphorylation status in head and neck squamous cell carcinoma

Head & Neck ◽  
2005 ◽  
Vol 27 (2) ◽  
pp. 130-137 ◽  
Author(s):  
Lara Tosi ◽  
Eliana Rinaldi ◽  
Francesco Carinci ◽  
Antonio Farina ◽  
Antonio Pastore ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Mitogen Activated Protein Kinase ◽  
Kinase C ◽  
Mitogen Activated Protein ◽  
Kinase Phosphorylation

Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines

2002 ◽  
Vol 13 (1) ◽  
pp. 93-100 ◽  
Author(s):  
Thomas K Hoffmann ◽  
Katrin Leenen ◽  
Dieter Hafner ◽  
Vera Balz ◽  
Claus D Gerharz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Antitumor Activity ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Protein Kinase C Inhibitors ◽  
Kinase C

scholarly journals Correlation of P38 Mitogen-Activated Protein Kinase Expression to Clinical Stage in Nasopharyngeal Carcinoma

2018 ◽  
Vol 6 (11) ◽  
pp. 1982-1985 ◽  
Author(s):  
Farhat Farhat ◽  
Elvita Rahmi Daulay ◽  
Jessy Chrestella ◽  
Rizalina Arwinati Asnir ◽  
Ashri Yudhistira ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Protein Kinase ◽  
Nasopharyngeal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Stage ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Keratinizing Squamous Cell Carcinoma ◽  
Kinase Expression

BACKGROUND: Nasopharyngeal carcinoma (NPC) is uncommon and usually diagnosed at the advanced stage. A subfamily of mitogen-activated protein kinase which is called p38 mitogen-activated protein kinase (MAPK) involved in response to stress, and plays an important role in cell regulation. There is a suggestion that p38 mitogen-activated protein kinase could be a potential biomarker to determine the clinical stage of nasopharyngeal carcinoma. AIM: The aim of this study is for observing and analysing the correlation of p38 mitogen-activated protein kinase expression in regards to nasopharyngeal carcinoma patient’s clinical stage. METHODS: This study involved 126 nasopharyngeal carcinoma patients admitted to Haji Adam Malik General Hospital. RESULTS: The result of this study indicates that nasopharyngeal carcinoma mostly found in the age group 41-60 years, male, non-keratinizing squamous cell carcinoma, and stage IV group. In immunohistochemistry evaluation, most of p38 mitogen-activated protein kinase overexpressed in non-keratinizing squamous cell carcinoma, T3-T4, N2-N3 and clinical stage III-IV. Spearman’s test for categorical correlation yield p-value of < 0.001. CONCLUSION: In conclusion, there is a significant correlation between p38 mitogen-activated protein kinase expression and the clinical stage of nasopharyngeal carcinoma.

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